Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02466:Zkscan7'

294589

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zkscan7

Ensembl Gene

ENSMUSG00000063488

Gene Name

zinc finger with KRAB and SCAN domains 7

Synonyms

Zfp167

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02466

Quality Score

Status

Chromosome

Chromosomal Location

122715883-122727684 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 122717950 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 115 (E115G)

Ref Sequence

ENSEMBL: ENSMUSP00000071695 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063980] [ENSMUST00000215872]

AlphaFold

E9PVW1

Predicted Effect

probably damaging
Transcript: ENSMUST00000063980
AA Change: E115G

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000071695
Gene: ENSMUSG00000063488
AA Change: E115G

Domain	Start	End	E-Value	Type
SCAN	45	156	1.18e-65	SMART
ZnF_C2H2	350	372	5.59e-4	SMART
ZnF_C2H2	378	400	3.69e-4	SMART
ZnF_C2H2	434	456	8.4e1	SMART
ZnF_C2H2	487	509	4.24e-4	SMART
ZnF_C2H2	515	537	8.34e-3	SMART
ZnF_C2H2	543	565	7.37e-4	SMART
ZnF_C2H2	571	593	1.92e-2	SMART
ZnF_C2H2	599	621	1.13e-4	SMART
ZnF_C2H2	627	649	2.24e-3	SMART
ZnF_C2H2	655	677	4.17e-3	SMART
ZnF_C2H2	683	705	1.04e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180486

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214426

Predicted Effect

probably benign
Transcript: ENSMUST00000215872
AA Change: E115G

PolyPhen 2 Score 0.272 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,247,527 (GRCm39)	F2425L	probably benign	Het
Adgre4	A	T	17: 56,121,188 (GRCm39)	Y418F	probably benign	Het
Adra1a	G	T	14: 66,875,322 (GRCm39)	C99F	probably damaging	Het
Aox3	C	A	1: 58,197,431 (GRCm39)	H592Q	probably benign	Het
Cacna1f	A	G	X: 7,495,644 (GRCm39)		probably null	Het
Cacna2d2	T	A	9: 107,342,753 (GRCm39)	I100N	probably damaging	Het
Cblif	A	T	19: 11,729,596 (GRCm39)	N185I	probably damaging	Het
Ccr9	T	A	9: 123,608,911 (GRCm39)	C198S	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Col4a3	T	A	1: 82,647,913 (GRCm39)	C475S	unknown	Het
Csnk2a2	T	C	8: 96,203,859 (GRCm39)	D100G	possibly damaging	Het
Cstf2t	G	A	19: 31,061,277 (GRCm39)	G271E	possibly damaging	Het
Fbxw22	T	C	9: 109,214,160 (GRCm39)	R219G	probably damaging	Het
Homez	A	G	14: 55,095,559 (GRCm39)	F50L	probably damaging	Het
Hspa4l	C	T	3: 40,707,657 (GRCm39)	Q81*	probably null	Het
Ifi202b	T	C	1: 173,799,875 (GRCm39)	D202G	possibly damaging	Het
Inava	T	C	1: 136,144,173 (GRCm39)		probably null	Het
Mansc1	T	A	6: 134,587,814 (GRCm39)	D121V	probably damaging	Het
Or13a24	A	G	7: 140,154,684 (GRCm39)	Y206C	probably benign	Het
Or4a27	T	G	2: 88,559,739 (GRCm39)	D68A	probably damaging	Het
Or51h5	T	A	7: 102,577,723 (GRCm39)	V296E	possibly damaging	Het
P2rx1	A	T	11: 72,900,410 (GRCm39)		probably null	Het
Phactr4	A	G	4: 132,104,483 (GRCm39)		probably benign	Het
Pus10	C	T	11: 23,675,574 (GRCm39)	T482I	probably damaging	Het
Scyl2	G	T	10: 89,488,871 (GRCm39)	Y206*	probably null	Het
Sell	G	A	1: 163,896,632 (GRCm39)		probably null	Het
Slfn10-ps	C	T	11: 82,921,090 (GRCm39)		noncoding transcript	Het
Ssh2	T	C	11: 77,307,233 (GRCm39)		probably benign	Het
Tas2r117	A	G	6: 132,779,963 (GRCm39)	M34V	probably benign	Het
Vmn2r103	A	T	17: 19,993,631 (GRCm39)	T3S	probably benign	Het
Vmn2r73	A	T	7: 85,522,084 (GRCm39)	I85K	probably damaging	Het
Vps13b	T	C	15: 35,770,887 (GRCm39)	V2110A	possibly damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zfp592	G	A	7: 80,673,746 (GRCm39)	G237R	probably damaging	Het
Zranb3	G	A	1: 127,943,829 (GRCm39)	T306M	probably benign	Het

Other mutations in Zkscan7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00594:Zkscan7	APN	9	122,724,659 (GRCm39)	missense	possibly damaging	0.95
IGL01650:Zkscan7	APN	9	122,723,892 (GRCm39)	missense	probably benign
IGL01905:Zkscan7	APN	9	122,719,826 (GRCm39)	missense	possibly damaging	0.93
R0310:Zkscan7	UTSW	9	122,717,958 (GRCm39)	nonsense	probably null
R0355:Zkscan7	UTSW	9	122,717,872 (GRCm39)	missense	probably damaging	1.00
R0477:Zkscan7	UTSW	9	122,719,874 (GRCm39)	splice site	probably null
R1276:Zkscan7	UTSW	9	122,719,788 (GRCm39)	missense	probably damaging	0.98
R1426:Zkscan7	UTSW	9	122,724,228 (GRCm39)	missense	probably benign
R2055:Zkscan7	UTSW	9	122,718,002 (GRCm39)	missense	probably damaging	1.00
R2195:Zkscan7	UTSW	9	122,724,686 (GRCm39)	missense	possibly damaging	0.73
R2354:Zkscan7	UTSW	9	122,723,892 (GRCm39)	missense	probably benign
R4878:Zkscan7	UTSW	9	122,719,865 (GRCm39)	nonsense	probably null
R5106:Zkscan7	UTSW	9	122,725,198 (GRCm39)	unclassified	probably benign
R6266:Zkscan7	UTSW	9	122,724,299 (GRCm39)	nonsense	probably null
R6299:Zkscan7	UTSW	9	122,717,782 (GRCm39)	missense	probably damaging	1.00
R6513:Zkscan7	UTSW	9	122,725,170 (GRCm39)	missense	probably benign	0.00
R6881:Zkscan7	UTSW	9	122,717,766 (GRCm39)	missense	possibly damaging	0.96
R7640:Zkscan7	UTSW	9	122,725,121 (GRCm39)	missense	possibly damaging	0.71
R7920:Zkscan7	UTSW	9	122,724,974 (GRCm39)	missense	probably benign	0.19

Posted On

2015-04-16