Incidental Mutation 'IGL02466:Zfp13'
| ID |
294592 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp13
|
| Ensembl Gene |
ENSMUSG00000062012 |
| Gene Name |
zinc finger protein 13 |
| Synonyms |
Krox-8, Zfp-13 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.124)
|
| Stock # |
IGL02466
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
23794818-23818461 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 23795072 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 493
(A493T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054595
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057029]
[ENSMUST00000115516]
[ENSMUST00000227952]
|
| AlphaFold |
P10754 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057029
AA Change: A493T
PolyPhen 2
Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
117 |
179 |
7.54e-10 |
SMART |
|
ZnF_C2H2
|
259 |
281 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
6.52e-5 |
SMART |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000115516
AA Change: A500T
|
| SMART Domains |
Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
124 |
186 |
7.54e-10 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
6.52e-5 |
SMART |
|
low complexity region
|
487 |
510 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226550
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227952
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228942
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,247,527 (GRCm39) |
F2425L |
probably benign |
Het |
| Adgre4 |
A |
T |
17: 56,121,188 (GRCm39) |
Y418F |
probably benign |
Het |
| Adra1a |
G |
T |
14: 66,875,322 (GRCm39) |
C99F |
probably damaging |
Het |
| Aox3 |
C |
A |
1: 58,197,431 (GRCm39) |
H592Q |
probably benign |
Het |
| Cacna1f |
A |
G |
X: 7,495,644 (GRCm39) |
|
probably null |
Het |
| Cacna2d2 |
T |
A |
9: 107,342,753 (GRCm39) |
I100N |
probably damaging |
Het |
| Cblif |
A |
T |
19: 11,729,596 (GRCm39) |
N185I |
probably damaging |
Het |
| Ccr9 |
T |
A |
9: 123,608,911 (GRCm39) |
C198S |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Col4a3 |
T |
A |
1: 82,647,913 (GRCm39) |
C475S |
unknown |
Het |
| Csnk2a2 |
T |
C |
8: 96,203,859 (GRCm39) |
D100G |
possibly damaging |
Het |
| Cstf2t |
G |
A |
19: 31,061,277 (GRCm39) |
G271E |
possibly damaging |
Het |
| Fbxw22 |
T |
C |
9: 109,214,160 (GRCm39) |
R219G |
probably damaging |
Het |
| Homez |
A |
G |
14: 55,095,559 (GRCm39) |
F50L |
probably damaging |
Het |
| Hspa4l |
C |
T |
3: 40,707,657 (GRCm39) |
Q81* |
probably null |
Het |
| Ifi202b |
T |
C |
1: 173,799,875 (GRCm39) |
D202G |
possibly damaging |
Het |
| Inava |
T |
C |
1: 136,144,173 (GRCm39) |
|
probably null |
Het |
| Mansc1 |
T |
A |
6: 134,587,814 (GRCm39) |
D121V |
probably damaging |
Het |
| Or13a24 |
A |
G |
7: 140,154,684 (GRCm39) |
Y206C |
probably benign |
Het |
| Or4a27 |
T |
G |
2: 88,559,739 (GRCm39) |
D68A |
probably damaging |
Het |
| Or51h5 |
T |
A |
7: 102,577,723 (GRCm39) |
V296E |
possibly damaging |
Het |
| P2rx1 |
A |
T |
11: 72,900,410 (GRCm39) |
|
probably null |
Het |
| Phactr4 |
A |
G |
4: 132,104,483 (GRCm39) |
|
probably benign |
Het |
| Pus10 |
C |
T |
11: 23,675,574 (GRCm39) |
T482I |
probably damaging |
Het |
| Scyl2 |
G |
T |
10: 89,488,871 (GRCm39) |
Y206* |
probably null |
Het |
| Sell |
G |
A |
1: 163,896,632 (GRCm39) |
|
probably null |
Het |
| Slfn10-ps |
C |
T |
11: 82,921,090 (GRCm39) |
|
noncoding transcript |
Het |
| Ssh2 |
T |
C |
11: 77,307,233 (GRCm39) |
|
probably benign |
Het |
| Tas2r117 |
A |
G |
6: 132,779,963 (GRCm39) |
M34V |
probably benign |
Het |
| Vmn2r103 |
A |
T |
17: 19,993,631 (GRCm39) |
T3S |
probably benign |
Het |
| Vmn2r73 |
A |
T |
7: 85,522,084 (GRCm39) |
I85K |
probably damaging |
Het |
| Vps13b |
T |
C |
15: 35,770,887 (GRCm39) |
V2110A |
possibly damaging |
Het |
| Zfp518a |
G |
A |
19: 40,903,061 (GRCm39) |
G997R |
probably damaging |
Het |
| Zfp592 |
G |
A |
7: 80,673,746 (GRCm39) |
G237R |
probably damaging |
Het |
| Zkscan7 |
A |
G |
9: 122,717,950 (GRCm39) |
E115G |
probably damaging |
Het |
| Zranb3 |
G |
A |
1: 127,943,829 (GRCm39) |
T306M |
probably benign |
Het |
|
| Other mutations in Zfp13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02236:Zfp13
|
APN |
17 |
23,799,739 (GRCm39) |
splice site |
probably benign |
|
|
IGL02447:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02449:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02450:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02468:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02471:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02473:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02474:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02475:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02491:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02511:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02558:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03030:Zfp13
|
APN |
17 |
23,799,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03388:Zfp13
|
APN |
17 |
23,795,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0053:Zfp13
|
UTSW |
17 |
23,795,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0053:Zfp13
|
UTSW |
17 |
23,795,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1514:Zfp13
|
UTSW |
17 |
23,795,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2420:Zfp13
|
UTSW |
17 |
23,795,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Zfp13
|
UTSW |
17 |
23,795,602 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4458:Zfp13
|
UTSW |
17 |
23,800,150 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4650:Zfp13
|
UTSW |
17 |
23,799,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4824:Zfp13
|
UTSW |
17 |
23,795,797 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5088:Zfp13
|
UTSW |
17 |
23,796,035 (GRCm39) |
nonsense |
probably null |
|
|
R5110:Zfp13
|
UTSW |
17 |
23,799,834 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5384:Zfp13
|
UTSW |
17 |
23,800,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7302:Zfp13
|
UTSW |
17 |
23,800,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8443:Zfp13
|
UTSW |
17 |
23,795,866 (GRCm39) |
missense |
probably benign |
|
|
R9728:Zfp13
|
UTSW |
17 |
23,799,788 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2015-04-16 |
Incidental Mutation