Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02471:Zfp446'

294737

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp446

Ensembl Gene

ENSMUSG00000033961

Gene Name

zinc finger protein 446

Synonyms

A630035I11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL02471

Quality Score

Status

Chromosome

Chromosomal Location

12711726-12718323 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 12716181 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glycine at position 209 (V209G)

Ref Sequence

ENSEMBL: ENSMUSP00000104177 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045810] [ENSMUST00000108535] [ENSMUST00000108536] [ENSMUST00000108537]

AlphaFold

Q8C9M8

Predicted Effect

probably benign
Transcript: ENSMUST00000045810
AA Change: V384G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000039073
Gene: ENSMUSG00000033961
AA Change: V384G

Domain	Start	End	E-Value	Type
low complexity region	67	79	N/A	INTRINSIC
SCAN	122	234	1.29e-53	SMART
KRAB	299	360	3.96e-2	SMART
ZnF_C2H2	419	441	2.95e-3	SMART
ZnF_C2H2	468	490	8.47e-4	SMART
ZnF_C2H2	496	518	5.34e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108535

SMART Domains

Protein: ENSMUSP00000104175
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	134	1.29e-53	SMART
KRAB	199	254	1.14e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108536
AA Change: V284G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000104176
Gene: ENSMUSG00000033961
AA Change: V284G

Domain	Start	End	E-Value	Type
SCAN	22	134	1.29e-53	SMART
KRAB	199	260	3.96e-2	SMART
ZnF_C2H2	319	341	2.95e-3	SMART
ZnF_C2H2	368	390	8.47e-4	SMART
ZnF_C2H2	396	418	5.34e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108537
AA Change: V209G

PolyPhen 2 Score 0.413 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000104177
Gene: ENSMUSG00000033961
AA Change: V209G

Domain	Start	End	E-Value	Type
SCAN	22	128	7.37e-49	SMART
KRAB	124	185	3.96e-2	SMART
ZnF_C2H2	244	266	2.95e-3	SMART
ZnF_C2H2	293	315	8.47e-4	SMART
ZnF_C2H2	321	343	5.34e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128427

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147996

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	G	T	1: 71,297,357 (GRCm39)	H2378N	probably benign	Het
Btaf1	C	A	19: 36,977,592 (GRCm39)	A1470E	probably damaging	Het
Ccdc110	A	G	8: 46,394,793 (GRCm39)	D228G	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cldn18	T	C	9: 99,578,128 (GRCm39)	D205G	probably benign	Het
Clip2	T	C	5: 134,546,876 (GRCm39)	T231A	probably benign	Het
Cltc	A	G	11: 86,608,860 (GRCm39)	V723A	probably damaging	Het
Cpa3	C	T	3: 20,282,971 (GRCm39)		probably null	Het
Cyfip2	T	G	11: 46,091,630 (GRCm39)	T1097P	possibly damaging	Het
Dnah9	T	A	11: 65,838,444 (GRCm39)	R667*	probably null	Het
Dock10	T	C	1: 80,493,339 (GRCm39)	E1878G	probably damaging	Het
Ermap	G	A	4: 119,037,160 (GRCm39)	H353Y	probably damaging	Het
Etfa	A	T	9: 55,393,984 (GRCm39)		probably null	Het
F5	C	T	1: 164,001,860 (GRCm39)	P188S	probably damaging	Het
Foxq1	G	A	13: 31,743,326 (GRCm39)	E143K	possibly damaging	Het
Gsr	C	T	8: 34,172,612 (GRCm39)		probably benign	Het
Hebp1	T	A	6: 135,132,274 (GRCm39)	Y31F	probably benign	Het
Ighv1-14	T	C	12: 114,610,457 (GRCm39)		noncoding transcript	Het
Lamb1	T	A	12: 31,370,907 (GRCm39)	D1319E	probably damaging	Het
Lrp5	A	T	19: 3,652,408 (GRCm39)	V1154E	probably benign	Het
Manba	G	A	3: 135,212,769 (GRCm39)		probably benign	Het
Mknk2	A	T	10: 80,503,955 (GRCm39)	F319I	probably damaging	Het
Mup6	A	T	4: 60,003,971 (GRCm39)		probably benign	Het
Nalcn	T	C	14: 123,560,726 (GRCm39)	T784A	probably benign	Het
Nt5dc1	T	C	10: 34,279,721 (GRCm39)	E107G	probably benign	Het
Or11h6	A	T	14: 50,880,214 (GRCm39)	I159F	probably benign	Het
Or56b34	T	A	7: 104,938,252 (GRCm39)	F317L	probably benign	Het
Or9q2	G	A	19: 13,772,589 (GRCm39)	P129S	probably damaging	Het
Phldb1	T	C	9: 44,622,530 (GRCm39)	E41G	probably damaging	Het
Ptk2	T	C	15: 73,170,036 (GRCm39)	D309G	probably benign	Het
Rab11fip5	A	G	6: 85,325,207 (GRCm39)	S367P	probably damaging	Het
Rb1cc1	T	A	1: 6,310,275 (GRCm39)	N224K	probably benign	Het
Rchy1	A	T	5: 92,105,405 (GRCm39)	C65*	probably null	Het
Rgs18	T	C	1: 144,650,359 (GRCm39)	D56G	probably benign	Het
Rtraf	A	C	14: 19,862,296 (GRCm39)	L197R	probably damaging	Het
Slc44a5	G	T	3: 153,962,213 (GRCm39)	W382L	probably damaging	Het
Snx24	C	T	18: 53,518,241 (GRCm39)		probably benign	Het
Sphkap	T	C	1: 83,253,897 (GRCm39)	D1284G	probably damaging	Het
Tmem54	A	G	4: 129,002,111 (GRCm39)	M53V	probably benign	Het
Trip6	G	A	5: 137,308,618 (GRCm39)	P414S	probably benign	Het
Vmn1r38	A	G	6: 66,753,751 (GRCm39)	Y122H	probably benign	Het
Wapl	T	A	14: 34,413,877 (GRCm39)	N246K	possibly damaging	Het
Zfp12	G	A	5: 143,230,551 (GRCm39)	G293R	probably damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het

Other mutations in Zfp446

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01486:Zfp446	APN	7	12,713,307 (GRCm39)	critical splice donor site	probably null
IGL01534:Zfp446	APN	7	12,713,493 (GRCm39)	missense	probably damaging	1.00
IGL02888:Zfp446	APN	7	12,713,255 (GRCm39)	missense	probably damaging	1.00
IGL03153:Zfp446	APN	7	12,711,834 (GRCm39)	missense	probably benign	0.01
IGL03185:Zfp446	APN	7	12,712,925 (GRCm39)	missense	probably null	0.43
IGL03242:Zfp446	APN	7	12,713,252 (GRCm39)	missense	probably damaging	1.00
R0538:Zfp446	UTSW	7	12,713,516 (GRCm39)	missense	possibly damaging	0.94
R1809:Zfp446	UTSW	7	12,713,048 (GRCm39)	missense	probably damaging	1.00
R3686:Zfp446	UTSW	7	12,716,580 (GRCm39)	missense	probably damaging	0.97
R3701:Zfp446	UTSW	7	12,712,079 (GRCm39)	unclassified	probably benign
R5256:Zfp446	UTSW	7	12,713,231 (GRCm39)	nonsense	probably null
R5363:Zfp446	UTSW	7	12,711,984 (GRCm39)	missense	probably benign	0.20
R5377:Zfp446	UTSW	7	12,716,178 (GRCm39)	missense	possibly damaging	0.88
R6806:Zfp446	UTSW	7	12,713,043 (GRCm39)	missense	probably damaging	1.00
R7167:Zfp446	UTSW	7	12,712,049 (GRCm39)	unclassified	probably benign
R7988:Zfp446	UTSW	7	12,712,970 (GRCm39)	missense	possibly damaging	0.93
R8288:Zfp446	UTSW	7	12,711,885 (GRCm39)	missense	probably benign	0.00
R8487:Zfp446	UTSW	7	12,716,555 (GRCm39)	missense	possibly damaging	0.68
R8943:Zfp446	UTSW	7	12,713,564 (GRCm39)	nonsense	probably null
R9315:Zfp446	UTSW	7	12,713,397 (GRCm39)	missense	probably benign	0.28
Z1177:Zfp446	UTSW	7	12,712,093 (GRCm39)	unclassified	probably benign

Posted On

2015-04-16