Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00226:Eif1ad'

29476

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif1ad

Ensembl Gene

ENSMUSG00000024841

Gene Name

eukaryotic translation initiation factor 1A domain containing

Synonyms

2010003J03Rik, Eif1ad1

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00226

Quality Score

Status

Chromosome

Chromosomal Location

5416841-5421546 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 5418212 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000126202 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025759] [ENSMUST00000025762] [ENSMUST00000170010]

AlphaFold

Q3THJ3

Predicted Effect

probably benign
Transcript: ENSMUST00000025759

SMART Domains

Protein: ENSMUSP00000025759
Gene: ENSMUSG00000024841

Domain	Start	End	E-Value	Type
eIF1a	20	103	1.03e-40	SMART
low complexity region	131	142	N/A	INTRINSIC
low complexity region	154	168	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000025762

SMART Domains

Protein: ENSMUSP00000025762
Gene: ENSMUSG00000024844

Domain	Start	End	E-Value	Type
BAF	1	88	3.68e-59	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000170010

SMART Domains

Protein: ENSMUSP00000126202
Gene: ENSMUSG00000024844

Domain	Start	End	E-Value	Type
BAF	1	88	3.68e-59	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810062G17Rik	C	A	3: 36,533,690 (GRCm39)		probably benign	Het
Ankib1	G	A	5: 3,777,573 (GRCm39)	S439L	probably benign	Het
Cdcp3	T	A	7: 130,839,823 (GRCm39)		probably null	Het
Cpd	G	T	11: 76,688,615 (GRCm39)	H886N	probably benign	Het
Dhrs7	A	G	12: 72,706,124 (GRCm39)	C94R	probably damaging	Het
Dmxl2	T	A	9: 54,323,277 (GRCm39)	H1369L	probably damaging	Het
Dnah5	A	G	15: 28,272,488 (GRCm39)	N1068S	probably benign	Het
Dop1a	T	A	9: 86,433,732 (GRCm39)	D2329E	possibly damaging	Het
Fam149a	T	C	8: 45,792,380 (GRCm39)	R693G	probably damaging	Het
Fbxw18	T	A	9: 109,522,411 (GRCm39)	T153S	probably benign	Het
Glg1	A	T	8: 111,886,481 (GRCm39)	C1104S	probably damaging	Het
Jak3	T	C	8: 72,134,341 (GRCm39)		probably benign	Het
Kctd6	C	T	14: 8,222,856 (GRCm38)	R233C	possibly damaging	Het
Kpna3	A	G	14: 61,611,737 (GRCm39)	V300A	possibly damaging	Het
Msh5	A	T	17: 35,248,857 (GRCm39)	Y725*	probably null	Het
Myh2	T	C	11: 67,076,059 (GRCm39)	S749P	possibly damaging	Het
Or2ag15	T	A	7: 106,340,908 (GRCm39)	T78S	probably benign	Het
Or4c110	A	G	2: 88,831,683 (GRCm39)		probably benign	Het
Or5ac17	A	T	16: 59,036,859 (GRCm39)	M39K	probably damaging	Het
Or8g19	T	A	9: 39,056,053 (GRCm39)	I219N	possibly damaging	Het
Pdcd1	A	G	1: 93,967,860 (GRCm39)		probably benign	Het
Pde5a	T	A	3: 122,588,006 (GRCm39)	F391I	probably damaging	Het
Ptpn12	A	C	5: 21,203,666 (GRCm39)	S371A	probably damaging	Het
Sec16b	A	G	1: 157,365,900 (GRCm39)	Y254C	probably damaging	Het
Slc2a10	G	A	2: 165,356,700 (GRCm39)	C120Y	probably damaging	Het
Spink5	G	A	18: 44,120,938 (GRCm39)		probably benign	Het
Svil	A	G	18: 5,099,045 (GRCm39)	Q1250R	probably benign	Het
Tph1	G	T	7: 46,306,294 (GRCm39)	N222K	probably benign	Het
Vmn2r83	A	T	10: 79,314,805 (GRCm39)	D351V	probably damaging	Het
Zfp54	A	G	17: 21,653,821 (GRCm39)	D105G	possibly damaging	Het
Zfp623	T	C	15: 75,820,052 (GRCm39)	I336T	probably damaging	Het

Other mutations in Eif1ad

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02012:Eif1ad	APN	19	5,418,687 (GRCm39)	missense	probably damaging	1.00
IGL02541:Eif1ad	APN	19	5,418,445 (GRCm39)	unclassified	probably benign
R0699:Eif1ad	UTSW	19	5,418,726 (GRCm39)	missense	possibly damaging	0.92
R1238:Eif1ad	UTSW	19	5,420,111 (GRCm39)	makesense	probably null
R1921:Eif1ad	UTSW	19	5,420,086 (GRCm39)	unclassified	probably benign
R2242:Eif1ad	UTSW	19	5,420,086 (GRCm39)	unclassified	probably benign
R3401:Eif1ad	UTSW	19	5,418,276 (GRCm39)	missense	probably benign	0.02
R4671:Eif1ad	UTSW	19	5,418,219 (GRCm39)	start codon destroyed	probably null	1.00
R7667:Eif1ad	UTSW	19	5,418,243 (GRCm39)	missense	probably damaging	1.00
R9010:Eif1ad	UTSW	19	5,418,726 (GRCm39)	missense	possibly damaging	0.92

Posted On

2013-04-17