Incidental Mutation 'IGL02473:Zfp13'
| ID |
294809 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp13
|
| Ensembl Gene |
ENSMUSG00000062012 |
| Gene Name |
zinc finger protein 13 |
| Synonyms |
Krox-8, Zfp-13 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.124)
|
| Stock # |
IGL02473
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
23794818-23818461 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 23795072 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 493
(A493T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054595
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057029]
[ENSMUST00000115516]
[ENSMUST00000227952]
|
| AlphaFold |
P10754 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057029
AA Change: A493T
PolyPhen 2
Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
117 |
179 |
7.54e-10 |
SMART |
|
ZnF_C2H2
|
259 |
281 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
6.52e-5 |
SMART |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000115516
AA Change: A500T
|
| SMART Domains |
Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
124 |
186 |
7.54e-10 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
6.52e-5 |
SMART |
|
low complexity region
|
487 |
510 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226550
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227952
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228942
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730480H06Rik |
G |
A |
5: 48,545,440 (GRCm39) |
|
probably benign |
Het |
| 9030624G23Rik |
A |
G |
12: 24,094,853 (GRCm39) |
F106S |
probably benign |
Het |
| A930011G23Rik |
T |
C |
5: 99,370,854 (GRCm39) |
Y468C |
probably damaging |
Het |
| Abcd3 |
T |
C |
3: 121,562,893 (GRCm39) |
T515A |
possibly damaging |
Het |
| Acrbp |
A |
G |
6: 125,031,661 (GRCm39) |
T321A |
probably benign |
Het |
| Aldh2 |
T |
C |
5: 121,710,141 (GRCm39) |
Y398C |
probably damaging |
Het |
| Baz2b |
T |
A |
2: 59,790,407 (GRCm39) |
D602V |
probably benign |
Het |
| Ccdc191 |
T |
C |
16: 43,777,257 (GRCm39) |
V714A |
probably benign |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cntn2 |
A |
G |
1: 132,446,069 (GRCm39) |
L839P |
probably benign |
Het |
| Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
| Cyp3a16 |
T |
C |
5: 145,377,304 (GRCm39) |
I428V |
possibly damaging |
Het |
| Dnah7b |
A |
T |
1: 46,273,353 (GRCm39) |
T2494S |
probably damaging |
Het |
| Dnaja3 |
T |
A |
16: 4,519,104 (GRCm39) |
Y348* |
probably null |
Het |
| Dnajb3 |
C |
A |
1: 88,133,104 (GRCm39) |
E99D |
probably benign |
Het |
| Igf2bp3 |
A |
G |
6: 49,071,163 (GRCm39) |
F411L |
probably benign |
Het |
| L3mbtl4 |
A |
T |
17: 68,866,772 (GRCm39) |
Y337F |
possibly damaging |
Het |
| Lias |
A |
G |
5: 65,562,745 (GRCm39) |
T258A |
possibly damaging |
Het |
| Lipk |
T |
A |
19: 34,016,548 (GRCm39) |
C254S |
probably damaging |
Het |
| Map4k1 |
T |
C |
7: 28,699,297 (GRCm39) |
L596S |
probably damaging |
Het |
| Mdga2 |
T |
C |
12: 66,597,385 (GRCm39) |
E703G |
possibly damaging |
Het |
| Mreg |
A |
G |
1: 72,201,495 (GRCm39) |
Y166H |
probably damaging |
Het |
| Or2f1b |
A |
G |
6: 42,739,640 (GRCm39) |
Y218C |
probably damaging |
Het |
| Or4b1b |
T |
C |
2: 90,112,040 (GRCm39) |
K293R |
probably null |
Het |
| Pcgf2 |
A |
G |
11: 97,582,747 (GRCm39) |
|
probably benign |
Het |
| Prdm15 |
T |
C |
16: 97,638,805 (GRCm39) |
|
probably null |
Het |
| Rnf111 |
A |
G |
9: 70,348,140 (GRCm39) |
V810A |
probably damaging |
Het |
| Rpl23a-ps1 |
A |
T |
1: 46,020,951 (GRCm39) |
|
noncoding transcript |
Het |
| Smc3 |
C |
A |
19: 53,624,879 (GRCm39) |
A779E |
probably benign |
Het |
| Smtn |
C |
T |
11: 3,482,463 (GRCm39) |
G140D |
probably damaging |
Het |
| Son |
T |
C |
16: 91,455,683 (GRCm39) |
S1477P |
probably damaging |
Het |
| Strn |
T |
C |
17: 78,991,722 (GRCm39) |
D20G |
possibly damaging |
Het |
| Tektl1 |
A |
T |
10: 78,586,428 (GRCm39) |
S208T |
probably benign |
Het |
| Tnxb |
T |
C |
17: 34,936,736 (GRCm39) |
L2798P |
probably damaging |
Het |
| Ttn |
A |
C |
2: 76,775,896 (GRCm39) |
N1715K |
probably damaging |
Het |
| Vps33a |
A |
T |
5: 123,707,634 (GRCm39) |
I111N |
probably damaging |
Het |
| Zscan4d |
A |
T |
7: 10,896,336 (GRCm39) |
C345S |
probably benign |
Het |
|
| Other mutations in Zfp13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02236:Zfp13
|
APN |
17 |
23,799,739 (GRCm39) |
splice site |
probably benign |
|
|
IGL02447:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02449:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02450:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02466:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02468:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02471:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02474:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02475:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02491:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02511:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02558:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03030:Zfp13
|
APN |
17 |
23,799,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03388:Zfp13
|
APN |
17 |
23,795,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0053:Zfp13
|
UTSW |
17 |
23,795,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0053:Zfp13
|
UTSW |
17 |
23,795,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1514:Zfp13
|
UTSW |
17 |
23,795,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2420:Zfp13
|
UTSW |
17 |
23,795,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Zfp13
|
UTSW |
17 |
23,795,602 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4458:Zfp13
|
UTSW |
17 |
23,800,150 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4650:Zfp13
|
UTSW |
17 |
23,799,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4824:Zfp13
|
UTSW |
17 |
23,795,797 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5088:Zfp13
|
UTSW |
17 |
23,796,035 (GRCm39) |
nonsense |
probably null |
|
|
R5110:Zfp13
|
UTSW |
17 |
23,799,834 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5384:Zfp13
|
UTSW |
17 |
23,800,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7302:Zfp13
|
UTSW |
17 |
23,800,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8443:Zfp13
|
UTSW |
17 |
23,795,866 (GRCm39) |
missense |
probably benign |
|
|
R9728:Zfp13
|
UTSW |
17 |
23,799,788 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2015-04-16 |
Incidental Mutation