Incidental Mutation 'IGL02478:Inmt'
ID 295030
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Inmt
Ensembl Gene ENSMUSG00000003477
Gene Name indolethylamine N-methyltransferase
Synonyms Temt
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # IGL02478
Quality Score
Status
Chromosome 6
Chromosomal Location 55147612-55151975 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 55150355 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 94 (E94G)
Ref Sequence ENSEMBL: ENSMUSP00000003569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003569]
AlphaFold P40936
Predicted Effect probably damaging
Transcript: ENSMUST00000003569
AA Change: E94G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000003569
Gene: ENSMUSG00000003477
AA Change: E94G

DomainStartEndE-ValueType
Pfam:NNMT_PNMT_TEMT 1 260 4.9e-113 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152720
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b C A 5: 8,856,018 (GRCm39) A42E probably damaging Het
Agmo T A 12: 37,451,985 (GRCm39) F247L probably damaging Het
Arap1 C A 7: 101,049,332 (GRCm39) probably null Het
Arid1a T C 4: 133,408,585 (GRCm39) D1974G unknown Het
Asxl3 C T 18: 22,656,070 (GRCm39) A1360V possibly damaging Het
Celsr1 T A 15: 85,825,337 (GRCm39) T1599S possibly damaging Het
Chrdl2 T C 7: 99,670,190 (GRCm39) probably null Het
Csmd3 T C 15: 47,701,794 (GRCm39) probably benign Het
Dis3l C T 9: 64,222,055 (GRCm39) E452K probably benign Het
Dnajc2 A T 5: 21,981,788 (GRCm39) H45Q probably damaging Het
Eps8 G A 6: 137,499,840 (GRCm39) P213L probably benign Het
Erbb3 T A 10: 128,407,227 (GRCm39) R978* probably null Het
Exoc2 A T 13: 31,111,403 (GRCm39) C142S probably benign Het
Fam184b T C 5: 45,695,039 (GRCm39) E735G probably damaging Het
Fancm T C 12: 65,123,864 (GRCm39) V174A probably damaging Het
Fat4 T C 3: 38,942,364 (GRCm39) L419P probably damaging Het
Fsip2 G T 2: 82,814,736 (GRCm39) V3490L probably benign Het
Ftcd A T 10: 76,417,255 (GRCm39) R255* probably null Het
Galc T C 12: 98,179,391 (GRCm39) N506S possibly damaging Het
Gm20441 G T 10: 75,608,644 (GRCm39) A26E probably damaging Het
Gm21969 T G 4: 139,367,999 (GRCm39) probably null Het
Ifitm3 T A 7: 140,589,787 (GRCm39) M89L possibly damaging Het
Ift25 T A 4: 107,132,449 (GRCm39) S79T probably benign Het
Insrr G A 3: 87,716,719 (GRCm39) G649D probably benign Het
Ivd T C 2: 118,692,572 (GRCm39) L24P probably benign Het
Kcnc1 A G 7: 46,084,593 (GRCm39) N506D probably benign Het
Krt39 T A 11: 99,411,723 (GRCm39) D121V probably benign Het
Lcp1 A G 14: 75,461,536 (GRCm39) I510V probably benign Het
Mkx C T 18: 7,002,418 (GRCm39) V43M probably damaging Het
Mmp2 A G 8: 93,579,235 (GRCm39) N108S possibly damaging Het
Mob1b T C 5: 88,903,947 (GRCm39) probably benign Het
Morc3 A G 16: 93,661,844 (GRCm39) probably benign Het
Myh13 T G 11: 67,260,204 (GRCm39) S1881A probably benign Het
Nalcn T C 14: 123,558,717 (GRCm39) E843G probably benign Het
Ngef A G 1: 87,408,301 (GRCm39) probably benign Het
Or14c40 T A 7: 86,313,344 (GRCm39) I158N probably damaging Het
Osm A G 11: 4,189,507 (GRCm39) Y97C probably damaging Het
Pclo T A 5: 14,816,792 (GRCm39) L4556Q unknown Het
Pcyox1l T C 18: 61,830,780 (GRCm39) D364G probably benign Het
Plekha6 T A 1: 133,211,031 (GRCm39) V467E probably benign Het
Qrsl1 A T 10: 43,758,158 (GRCm39) S312T probably damaging Het
Ripk1 T A 13: 34,194,572 (GRCm39) L70Q probably damaging Het
Rnaseh1 A T 12: 28,705,662 (GRCm39) Y162F probably damaging Het
Ror2 T A 13: 53,275,703 (GRCm39) T195S probably damaging Het
Sh3bp2 T C 5: 34,709,006 (GRCm39) L33P probably damaging Het
Skil T A 3: 31,151,968 (GRCm39) C163* probably null Het
Slc25a37 A T 14: 69,486,883 (GRCm39) N133K probably benign Het
Slitrk3 A C 3: 72,958,046 (GRCm39) V242G probably damaging Het
Sra1 A G 18: 36,801,845 (GRCm39) S82P probably benign Het
Synj2 A G 17: 6,088,199 (GRCm39) N1417D probably benign Het
Tas2r122 A G 6: 132,688,578 (GRCm39) V105A possibly damaging Het
Tasor2 T C 13: 3,624,661 (GRCm39) E1763G probably benign Het
Ttc21b T C 2: 66,018,624 (GRCm39) N1261S probably benign Het
Vmn2r69 A G 7: 85,055,889 (GRCm39) S750P probably damaging Het
Wdr95 A G 5: 149,519,786 (GRCm39) T568A probably benign Het
Zfp319 T A 8: 96,055,721 (GRCm39) I161F possibly damaging Het
Other mutations in Inmt
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Inmt APN 6 55,148,213 (GRCm39) missense probably damaging 1.00
IGL02404:Inmt APN 6 55,148,095 (GRCm39) missense possibly damaging 0.67
IGL02585:Inmt APN 6 55,150,431 (GRCm39) missense probably damaging 1.00
R0639:Inmt UTSW 6 55,148,212 (GRCm39) missense probably damaging 1.00
R0673:Inmt UTSW 6 55,148,212 (GRCm39) missense probably damaging 1.00
R1818:Inmt UTSW 6 55,150,404 (GRCm39) missense possibly damaging 0.92
R1862:Inmt UTSW 6 55,151,868 (GRCm39) missense probably damaging 1.00
R4383:Inmt UTSW 6 55,148,203 (GRCm39) missense probably damaging 1.00
R4529:Inmt UTSW 6 55,148,012 (GRCm39) missense probably benign 0.01
R5057:Inmt UTSW 6 55,151,883 (GRCm39) missense probably benign 0.00
R5999:Inmt UTSW 6 55,151,933 (GRCm39) nonsense probably null
R7135:Inmt UTSW 6 55,148,013 (GRCm39) nonsense probably null
R9242:Inmt UTSW 6 55,150,270 (GRCm39) critical splice donor site probably null
R9353:Inmt UTSW 6 55,151,984 (GRCm39) start gained probably benign
R9476:Inmt UTSW 6 55,147,990 (GRCm39) missense possibly damaging 0.95
R9510:Inmt UTSW 6 55,147,990 (GRCm39) missense possibly damaging 0.95
X0021:Inmt UTSW 6 55,150,281 (GRCm39) missense probably damaging 0.98
X0022:Inmt UTSW 6 55,150,460 (GRCm39) missense probably benign 0.40
Posted On 2015-04-16