Incidental Mutation 'IGL02480:Lzic'
ID 295160
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lzic
Ensembl Gene ENSMUSG00000028990
Gene Name leucine zipper and CTNNBIP1 domain containing
Synonyms 1810030J04Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.152) question?
Stock # IGL02480
Quality Score
Status
Chromosome 4
Chromosomal Location 149569686-149581125 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 149571260 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 15 (N15I)
Ref Sequence ENSEMBL: ENSMUSP00000116150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030842] [ENSMUST00000030845] [ENSMUST00000105693] [ENSMUST00000119921] [ENSMUST00000124413] [ENSMUST00000141293] [ENSMUST00000210722] [ENSMUST00000126896] [ENSMUST00000229840]
AlphaFold Q8K3C3
Predicted Effect probably damaging
Transcript: ENSMUST00000030842
AA Change: N15I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000030842
Gene: ENSMUSG00000028990
AA Change: N15I

DomainStartEndE-ValueType
coiled coil region 2 63 N/A INTRINSIC
Pfam:ICAT 113 188 5.7e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000030845
SMART Domains Protein: ENSMUSP00000030845
Gene: ENSMUSG00000028992

DomainStartEndE-ValueType
Pfam:CTP_transf_2 12 230 2.5e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105693
SMART Domains Protein: ENSMUSP00000101318
Gene: ENSMUSG00000028992

DomainStartEndE-ValueType
Pfam:CTP_transf_like 12 230 9.5e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119921
SMART Domains Protein: ENSMUSP00000113156
Gene: ENSMUSG00000028992

DomainStartEndE-ValueType
Pfam:CTP_transf_2 12 140 9.8e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122947
Predicted Effect probably damaging
Transcript: ENSMUST00000124413
AA Change: N15I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000116150
Gene: ENSMUSG00000028990
AA Change: N15I

DomainStartEndE-ValueType
SCOP:d1lxa__ 11 56 7e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000141293
AA Change: N15I

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000119294
Gene: ENSMUSG00000028990
AA Change: N15I

DomainStartEndE-ValueType
SCOP:d1lxa__ 11 61 1e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000210722
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146427
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138464
Predicted Effect probably benign
Transcript: ENSMUST00000126896
Predicted Effect probably benign
Transcript: ENSMUST00000229840
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac T A 3: 59,946,908 (GRCm39) I202K probably benign Het
Abcc1 T A 16: 14,221,869 (GRCm39) S169T possibly damaging Het
Acsm1 A T 7: 119,255,265 (GRCm39) I389F possibly damaging Het
Actn2 T A 13: 12,291,364 (GRCm39) Q680L probably benign Het
Ankrd13d G A 19: 4,321,491 (GRCm39) P404S possibly damaging Het
Ankrd46 G T 15: 36,484,142 (GRCm39) probably benign Het
Arfip1 A G 3: 84,455,239 (GRCm39) probably null Het
Asb15 A T 6: 24,570,745 (GRCm39) L574F probably damaging Het
Cym T C 3: 107,120,838 (GRCm39) I256V probably benign Het
Cyp3a44 C T 5: 145,731,715 (GRCm39) E144K possibly damaging Het
Efna1 T C 3: 89,179,902 (GRCm39) E109G probably benign Het
Eif4a3l1 A T 6: 136,306,213 (GRCm39) I225F probably damaging Het
Eml1 C A 12: 108,487,955 (GRCm39) Q556K probably benign Het
Eml5 T G 12: 98,842,502 (GRCm39) T199P probably damaging Het
Entr1 T A 2: 26,275,132 (GRCm39) H342L probably damaging Het
Etl4 A C 2: 20,793,335 (GRCm39) M687L probably damaging Het
Fam199x C A X: 135,950,788 (GRCm39) T56K probably damaging Het
Fat4 A G 3: 39,064,579 (GRCm39) D4845G probably damaging Het
Gm4987 T A X: 45,544,973 (GRCm39) noncoding transcript Het
Gm5828 C A 1: 16,839,766 (GRCm39) noncoding transcript Het
Gm5930 T C 14: 44,575,087 (GRCm39) Y68C probably benign Het
Gucy1a1 C T 3: 82,005,040 (GRCm39) V582M probably damaging Het
Haghl G T 17: 26,002,033 (GRCm39) A220E probably damaging Het
Hsf5 G A 11: 87,522,483 (GRCm39) A359T possibly damaging Het
Igsf9 C A 1: 172,324,480 (GRCm39) D799E possibly damaging Het
Igsf9 A T 1: 172,312,345 (GRCm39) probably benign Het
Itga1 A T 13: 115,124,184 (GRCm39) F703I probably damaging Het
Kcna6 G A 6: 126,715,531 (GRCm39) P453S probably damaging Het
Or1j10 T G 2: 36,267,504 (GRCm39) C239G probably damaging Het
Or2n1d A G 17: 38,646,314 (GRCm39) R89G probably benign Het
Or4f54 A G 2: 111,122,858 (GRCm39) I82V possibly damaging Het
Or5p78 C T 7: 108,212,018 (GRCm39) T168I probably benign Het
P4ha1 T C 10: 59,179,574 (GRCm39) Y141H probably damaging Het
Paxx G A 2: 25,350,024 (GRCm39) P164S probably damaging Het
Pgd A G 4: 149,241,075 (GRCm39) V278A probably damaging Het
Pik3c2g A G 6: 139,798,526 (GRCm39) Y352C probably damaging Het
Pkd2l2 A G 18: 34,571,843 (GRCm39) N614S possibly damaging Het
Poli T C 18: 70,658,477 (GRCm39) T86A probably benign Het
Psd2 G A 18: 36,139,136 (GRCm39) R528H probably damaging Het
Ptchd4 G T 17: 42,813,431 (GRCm39) C444F probably benign Het
Ptpra C A 2: 130,346,181 (GRCm39) T114K probably benign Het
Rho A G 6: 115,912,505 (GRCm39) N123S probably benign Het
Setd5 A G 6: 113,120,770 (GRCm39) D993G probably damaging Het
Slc1a2 T C 2: 102,566,411 (GRCm39) L38P probably damaging Het
Slc2a7 G A 4: 150,244,569 (GRCm39) V346M possibly damaging Het
Slc43a1 A G 2: 84,669,928 (GRCm39) I7V probably benign Het
Spag9 C T 11: 93,999,413 (GRCm39) Q691* probably null Het
Timmdc1 A T 16: 38,342,763 (GRCm39) V45D probably null Het
Tlr8 T A X: 166,027,179 (GRCm39) H557L probably damaging Het
Other mutations in Lzic
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Lzic APN 4 149,577,753 (GRCm39) critical splice donor site probably null
IGL01433:Lzic APN 4 149,572,604 (GRCm39) missense probably benign 0.00
R0097:Lzic UTSW 4 149,572,533 (GRCm39) missense probably damaging 1.00
R0097:Lzic UTSW 4 149,572,533 (GRCm39) missense probably damaging 1.00
R1345:Lzic UTSW 4 149,571,308 (GRCm39) missense probably damaging 1.00
R2162:Lzic UTSW 4 149,573,185 (GRCm39) missense probably null 0.01
R3831:Lzic UTSW 4 149,573,185 (GRCm39) missense probably null 0.01
R4589:Lzic UTSW 4 149,572,561 (GRCm39) missense probably damaging 0.98
R4929:Lzic UTSW 4 149,572,585 (GRCm39) splice site probably null
R5837:Lzic UTSW 4 149,570,457 (GRCm39) critical splice donor site probably null
R7126:Lzic UTSW 4 149,573,132 (GRCm39) missense probably damaging 0.99
R8154:Lzic UTSW 4 149,573,141 (GRCm39) missense probably damaging 1.00
R8316:Lzic UTSW 4 149,572,527 (GRCm39) missense probably benign 0.03
R9632:Lzic UTSW 4 149,573,141 (GRCm39) missense probably damaging 1.00
R9710:Lzic UTSW 4 149,573,141 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16