Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02490:Iqcg'

295583

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iqcg

Ensembl Gene

ENSMUSG00000035578

Gene Name

IQ motif containing G

Synonyms

2400003L07Rik, esgd12d, repro1, stubby12d, G1-374-12

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02490

Quality Score

Status

Chromosome

Chromosomal Location

32834640-32876617 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 32855937 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 213 (K213*)

Ref Sequence

ENSEMBL: ENSMUSP00000110752 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115100]

AlphaFold

Q80W32

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000105610

Predicted Effect

probably null
Transcript: ENSMUST00000115100
AA Change: K213*

SMART Domains

Protein: ENSMUSP00000110752
Gene: ENSMUSG00000035578
AA Change: K213*

Domain	Start	End	E-Value	Type
low complexity region	3	50	N/A	INTRINSIC
low complexity region	101	116	N/A	INTRINSIC
coiled coil region	248	329	N/A	INTRINSIC
IQ	371	393	1.54e-2	SMART
low complexity region	399	419	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231235

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous male mice are infertile and have very low epididymal sperm concentration with low motility, predominantly appearing as sperm heads without tails or with short tails. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D06Rik	A	G	6: 89,078,559 (GRCm39)		noncoding transcript	Het
Adam5	A	T	8: 25,271,720 (GRCm39)	Y562*	probably null	Het
Akr1d1	T	C	6: 37,535,423 (GRCm39)	V269A	probably damaging	Het
Anks4b	A	G	7: 119,773,241 (GRCm39)	T34A	probably damaging	Het
Arhgef40	A	G	14: 52,226,652 (GRCm39)	N232S	probably damaging	Het
Cdc40	C	T	10: 40,717,767 (GRCm39)	V379I	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdh13	A	G	8: 119,822,062 (GRCm39)	D307G	probably damaging	Het
Ces1h	A	G	8: 94,083,627 (GRCm39)		probably null	Het
Chchd6	T	A	6: 89,361,656 (GRCm39)	H249L	possibly damaging	Het
Clxn	T	A	16: 14,734,810 (GRCm39)	V60E	probably benign	Het
Cul1	T	C	6: 47,491,820 (GRCm39)	V392A	probably damaging	Het
Cwc15	A	T	9: 14,413,320 (GRCm39)	D34V	probably damaging	Het
Cyp2c39	T	C	19: 39,527,446 (GRCm39)	I264T	probably damaging	Het
Dapk1	A	G	13: 60,897,148 (GRCm39)	D789G	probably damaging	Het
Dcdc2a	T	A	13: 25,291,635 (GRCm39)	Y207N	probably damaging	Het
Flt3	T	A	5: 147,268,106 (GRCm39)	N960Y	probably damaging	Het
Fmn1	C	T	2: 113,359,817 (GRCm39)		probably benign	Het
Foxm1	T	A	6: 128,350,314 (GRCm39)	C400*	probably null	Het
Ftmt	A	C	18: 52,464,760 (GRCm39)	R25S	probably benign	Het
Guca1b	T	C	17: 47,700,190 (GRCm39)		probably benign	Het
Hectd4	A	T	5: 121,456,676 (GRCm39)	K680N	possibly damaging	Het
Hephl1	C	A	9: 14,964,981 (GRCm39)	R1138L	probably benign	Het
Il1rl2	T	A	1: 40,395,972 (GRCm39)		probably benign	Het
Ints2	A	T	11: 86,124,009 (GRCm39)	I593K	possibly damaging	Het
Kif1b	T	A	4: 149,288,665 (GRCm39)	S1259C	probably benign	Het
Klc1	C	T	12: 111,748,210 (GRCm39)	T371M	possibly damaging	Het
Loxl4	T	C	19: 42,593,269 (GRCm39)	T301A	probably benign	Het
Lrrc40	T	C	3: 157,768,336 (GRCm39)	L497P	probably damaging	Het
Masp2	C	T	4: 148,692,400 (GRCm39)	R298W	possibly damaging	Het
Myo5a	A	T	9: 75,043,737 (GRCm39)	Y242F	probably damaging	Het
Nup98	A	G	7: 101,801,573 (GRCm39)	V784A	probably damaging	Het
Or5w15	T	C	2: 87,568,299 (GRCm39)	Y123C	probably damaging	Het
Osbpl1a	G	T	18: 13,015,341 (GRCm39)		probably benign	Het
Pcdh10	A	G	3: 45,334,922 (GRCm39)	Y412C	probably damaging	Het
Pfkfb2	T	A	1: 130,628,589 (GRCm39)	Y339F	probably damaging	Het
Plcb2	T	C	2: 118,550,241 (GRCm39)	N172D	probably damaging	Het
Plec	T	C	15: 76,073,463 (GRCm39)	Y517C	probably damaging	Het
Plod2	G	T	9: 92,468,895 (GRCm39)	A207S	probably benign	Het
Plxdc1	A	T	11: 97,845,604 (GRCm39)	D229E	probably benign	Het
Ppp3cb	A	G	14: 20,581,726 (GRCm39)		probably null	Het
Procr	T	C	2: 155,595,352 (GRCm39)	L52P	probably damaging	Het
Psme2b	G	T	11: 48,836,946 (GRCm39)		probably benign	Het
Rgs22	G	A	15: 36,054,993 (GRCm39)	A727V	probably damaging	Het
Rock2	T	A	12: 16,998,564 (GRCm39)	W277R	probably damaging	Het
Rpl26	A	G	11: 68,795,216 (GRCm39)	D112G	probably damaging	Het
Rxfp1	C	A	3: 79,559,474 (GRCm39)		probably null	Het
Sdr39u1	G	A	14: 56,135,798 (GRCm39)	P98L	probably damaging	Het
Sgms1	T	C	19: 32,137,543 (GRCm39)	K8E	probably damaging	Het
Stk31	T	C	6: 49,394,469 (GRCm39)	V277A	probably benign	Het
Trav15-1-dv6-1	A	C	14: 53,797,588 (GRCm39)	E79A	probably benign	Het
Ttll6	A	T	11: 96,047,546 (GRCm39)	D715V	possibly damaging	Het
Ush2a	T	C	1: 188,542,561 (GRCm39)	S3376P	probably damaging	Het
Vmn2r109	T	A	17: 20,761,246 (GRCm39)	T704S	possibly damaging	Het
Zfp27	T	A	7: 29,594,360 (GRCm39)	H535L	possibly damaging	Het
Zfp609	A	T	9: 65,611,250 (GRCm39)	V571D	possibly damaging	Het
Zfp874a	A	T	13: 67,590,819 (GRCm39)	Y288*	probably null	Het
Zfp993	T	C	4: 146,742,074 (GRCm39)	S133P	probably damaging	Het

Other mutations in Iqcg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01106:Iqcg	APN	16	32,855,970 (GRCm39)	missense	possibly damaging	0.90
IGL01155:Iqcg	APN	16	32,861,245 (GRCm39)	missense	probably damaging	0.99
IGL01602:Iqcg	APN	16	32,837,348 (GRCm39)	unclassified	probably benign
IGL01605:Iqcg	APN	16	32,837,348 (GRCm39)	unclassified	probably benign
IGL02243:Iqcg	APN	16	32,865,962 (GRCm39)	missense	probably damaging	1.00
IGL02328:Iqcg	APN	16	32,839,876 (GRCm39)	missense	probably benign	0.00
IGL03297:Iqcg	APN	16	32,856,002 (GRCm39)	splice site	probably benign
R0038:Iqcg	UTSW	16	32,866,012 (GRCm39)	missense	probably benign	0.03
R0453:Iqcg	UTSW	16	32,870,213 (GRCm39)	splice site	probably benign
R0719:Iqcg	UTSW	16	32,861,215 (GRCm39)	missense	probably benign	0.26
R1191:Iqcg	UTSW	16	32,870,313 (GRCm39)	missense	probably benign	0.43
R1544:Iqcg	UTSW	16	32,865,895 (GRCm39)	missense	probably benign	0.01
R2292:Iqcg	UTSW	16	32,870,253 (GRCm39)	missense	probably benign	0.25
R3725:Iqcg	UTSW	16	32,840,909 (GRCm39)	splice site	probably null
R3726:Iqcg	UTSW	16	32,849,411 (GRCm39)	missense	probably damaging	1.00
R3732:Iqcg	UTSW	16	32,873,996 (GRCm39)	unclassified	probably benign
R3732:Iqcg	UTSW	16	32,873,996 (GRCm39)	unclassified	probably benign
R3733:Iqcg	UTSW	16	32,873,996 (GRCm39)	unclassified	probably benign
R3734:Iqcg	UTSW	16	32,873,996 (GRCm39)	unclassified	probably benign
R3770:Iqcg	UTSW	16	32,870,378 (GRCm39)	synonymous	silent
R4296:Iqcg	UTSW	16	32,837,345 (GRCm39)	unclassified	probably benign
R4409:Iqcg	UTSW	16	32,865,888 (GRCm39)	critical splice donor site	probably null
R4410:Iqcg	UTSW	16	32,851,186 (GRCm39)	missense	possibly damaging	0.95
R4429:Iqcg	UTSW	16	32,839,860 (GRCm39)	missense	probably benign	0.02
R4603:Iqcg	UTSW	16	32,861,133 (GRCm39)	critical splice donor site	probably null
R4603:Iqcg	UTSW	16	32,861,134 (GRCm39)	missense	probably null	0.68
R4979:Iqcg	UTSW	16	32,839,884 (GRCm39)	missense	probably damaging	1.00
R5672:Iqcg	UTSW	16	32,839,878 (GRCm39)	missense	probably damaging	0.99
R6183:Iqcg	UTSW	16	32,851,293 (GRCm39)	missense	probably damaging	1.00
R6965:Iqcg	UTSW	16	32,851,174 (GRCm39)	missense	probably benign	0.06
R8135:Iqcg	UTSW	16	32,849,394 (GRCm39)	missense	probably benign	0.20
R9260:Iqcg	UTSW	16	32,855,973 (GRCm39)	nonsense	probably null
R9505:Iqcg	UTSW	16	32,861,247 (GRCm39)	missense	probably benign	0.42
Z1177:Iqcg	UTSW	16	32,849,390 (GRCm39)	nonsense	probably null

Posted On

2015-04-16