Incidental Mutation 'IGL02490:Zfp874a'
ID 295586
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp874a
Ensembl Gene ENSMUSG00000069206
Gene Name zinc finger protein 874a
Synonyms C330011K17Rik, Zfp874, Rslcan15
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL02490
Quality Score
Status
Chromosome 13
Chromosomal Location 67588550-67599743 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 67590819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 288 (Y288*)
Ref Sequence ENSEMBL: ENSMUSP00000074735 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057241] [ENSMUST00000075255] [ENSMUST00000180580] [ENSMUST00000223682] [ENSMUST00000225479]
AlphaFold Q8BX23
Predicted Effect probably benign
Transcript: ENSMUST00000057241
SMART Domains Protein: ENSMUSP00000077307
Gene: ENSMUSG00000069206

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
Predicted Effect probably null
Transcript: ENSMUST00000075255
AA Change: Y288*
SMART Domains Protein: ENSMUSP00000074735
Gene: ENSMUSG00000069206
AA Change: Y288*

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
ZnF_C2H2 137 159 9.58e-3 SMART
ZnF_C2H2 165 187 5.99e-4 SMART
ZnF_C2H2 193 215 7.26e-3 SMART
ZnF_C2H2 221 243 2.4e-3 SMART
ZnF_C2H2 249 269 1.88e2 SMART
ZnF_C2H2 277 299 5.21e-4 SMART
ZnF_C2H2 305 327 2.12e-4 SMART
ZnF_C2H2 333 355 2.12e-4 SMART
ZnF_C2H2 361 383 8.47e-4 SMART
ZnF_C2H2 389 411 1.79e-2 SMART
ZnF_C2H2 417 438 2.86e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180580
SMART Domains Protein: ENSMUSP00000137953
Gene: ENSMUSG00000069206

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223682
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224239
Predicted Effect probably benign
Transcript: ENSMUST00000225479
Predicted Effect probably benign
Transcript: ENSMUST00000225778
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D06Rik A G 6: 89,078,559 (GRCm39) noncoding transcript Het
Adam5 A T 8: 25,271,720 (GRCm39) Y562* probably null Het
Akr1d1 T C 6: 37,535,423 (GRCm39) V269A probably damaging Het
Anks4b A G 7: 119,773,241 (GRCm39) T34A probably damaging Het
Arhgef40 A G 14: 52,226,652 (GRCm39) N232S probably damaging Het
Cdc40 C T 10: 40,717,767 (GRCm39) V379I probably benign Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cdh13 A G 8: 119,822,062 (GRCm39) D307G probably damaging Het
Ces1h A G 8: 94,083,627 (GRCm39) probably null Het
Chchd6 T A 6: 89,361,656 (GRCm39) H249L possibly damaging Het
Clxn T A 16: 14,734,810 (GRCm39) V60E probably benign Het
Cul1 T C 6: 47,491,820 (GRCm39) V392A probably damaging Het
Cwc15 A T 9: 14,413,320 (GRCm39) D34V probably damaging Het
Cyp2c39 T C 19: 39,527,446 (GRCm39) I264T probably damaging Het
Dapk1 A G 13: 60,897,148 (GRCm39) D789G probably damaging Het
Dcdc2a T A 13: 25,291,635 (GRCm39) Y207N probably damaging Het
Flt3 T A 5: 147,268,106 (GRCm39) N960Y probably damaging Het
Fmn1 C T 2: 113,359,817 (GRCm39) probably benign Het
Foxm1 T A 6: 128,350,314 (GRCm39) C400* probably null Het
Ftmt A C 18: 52,464,760 (GRCm39) R25S probably benign Het
Guca1b T C 17: 47,700,190 (GRCm39) probably benign Het
Hectd4 A T 5: 121,456,676 (GRCm39) K680N possibly damaging Het
Hephl1 C A 9: 14,964,981 (GRCm39) R1138L probably benign Het
Il1rl2 T A 1: 40,395,972 (GRCm39) probably benign Het
Ints2 A T 11: 86,124,009 (GRCm39) I593K possibly damaging Het
Iqcg T A 16: 32,855,937 (GRCm39) K213* probably null Het
Kif1b T A 4: 149,288,665 (GRCm39) S1259C probably benign Het
Klc1 C T 12: 111,748,210 (GRCm39) T371M possibly damaging Het
Loxl4 T C 19: 42,593,269 (GRCm39) T301A probably benign Het
Lrrc40 T C 3: 157,768,336 (GRCm39) L497P probably damaging Het
Masp2 C T 4: 148,692,400 (GRCm39) R298W possibly damaging Het
Myo5a A T 9: 75,043,737 (GRCm39) Y242F probably damaging Het
Nup98 A G 7: 101,801,573 (GRCm39) V784A probably damaging Het
Or5w15 T C 2: 87,568,299 (GRCm39) Y123C probably damaging Het
Osbpl1a G T 18: 13,015,341 (GRCm39) probably benign Het
Pcdh10 A G 3: 45,334,922 (GRCm39) Y412C probably damaging Het
Pfkfb2 T A 1: 130,628,589 (GRCm39) Y339F probably damaging Het
Plcb2 T C 2: 118,550,241 (GRCm39) N172D probably damaging Het
Plec T C 15: 76,073,463 (GRCm39) Y517C probably damaging Het
Plod2 G T 9: 92,468,895 (GRCm39) A207S probably benign Het
Plxdc1 A T 11: 97,845,604 (GRCm39) D229E probably benign Het
Ppp3cb A G 14: 20,581,726 (GRCm39) probably null Het
Procr T C 2: 155,595,352 (GRCm39) L52P probably damaging Het
Psme2b G T 11: 48,836,946 (GRCm39) probably benign Het
Rgs22 G A 15: 36,054,993 (GRCm39) A727V probably damaging Het
Rock2 T A 12: 16,998,564 (GRCm39) W277R probably damaging Het
Rpl26 A G 11: 68,795,216 (GRCm39) D112G probably damaging Het
Rxfp1 C A 3: 79,559,474 (GRCm39) probably null Het
Sdr39u1 G A 14: 56,135,798 (GRCm39) P98L probably damaging Het
Sgms1 T C 19: 32,137,543 (GRCm39) K8E probably damaging Het
Stk31 T C 6: 49,394,469 (GRCm39) V277A probably benign Het
Trav15-1-dv6-1 A C 14: 53,797,588 (GRCm39) E79A probably benign Het
Ttll6 A T 11: 96,047,546 (GRCm39) D715V possibly damaging Het
Ush2a T C 1: 188,542,561 (GRCm39) S3376P probably damaging Het
Vmn2r109 T A 17: 20,761,246 (GRCm39) T704S possibly damaging Het
Zfp27 T A 7: 29,594,360 (GRCm39) H535L possibly damaging Het
Zfp609 A T 9: 65,611,250 (GRCm39) V571D possibly damaging Het
Zfp993 T C 4: 146,742,074 (GRCm39) S133P probably damaging Het
Other mutations in Zfp874a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1052:Zfp874a UTSW 13 67,590,539 (GRCm39) missense possibly damaging 0.89
R1991:Zfp874a UTSW 13 67,590,623 (GRCm39) missense probably benign 0.03
R2085:Zfp874a UTSW 13 67,590,967 (GRCm39) missense probably damaging 1.00
R2103:Zfp874a UTSW 13 67,590,623 (GRCm39) missense probably benign 0.03
R5129:Zfp874a UTSW 13 67,591,100 (GRCm39) missense probably damaging 1.00
R5336:Zfp874a UTSW 13 67,590,799 (GRCm39) missense probably damaging 1.00
R5423:Zfp874a UTSW 13 67,590,473 (GRCm39) missense possibly damaging 0.75
R5713:Zfp874a UTSW 13 67,597,476 (GRCm39) missense probably benign 0.16
R5855:Zfp874a UTSW 13 67,590,812 (GRCm39) missense probably benign 0.03
R6496:Zfp874a UTSW 13 67,590,694 (GRCm39) missense possibly damaging 0.62
R7046:Zfp874a UTSW 13 67,590,418 (GRCm39) missense probably damaging 1.00
R7065:Zfp874a UTSW 13 67,590,401 (GRCm39) missense probably damaging 0.97
R7233:Zfp874a UTSW 13 67,590,776 (GRCm39) missense possibly damaging 0.83
R7271:Zfp874a UTSW 13 67,591,415 (GRCm39) missense probably benign 0.00
R7465:Zfp874a UTSW 13 67,590,376 (GRCm39) missense probably damaging 0.99
R7468:Zfp874a UTSW 13 67,573,723 (GRCm39) splice site probably null
R8108:Zfp874a UTSW 13 67,591,353 (GRCm39) nonsense probably null
R8109:Zfp874a UTSW 13 67,597,563 (GRCm39) missense possibly damaging 0.46
R8843:Zfp874a UTSW 13 67,590,764 (GRCm39) missense probably damaging 1.00
R8859:Zfp874a UTSW 13 67,590,647 (GRCm39) missense probably benign 0.17
R9137:Zfp874a UTSW 13 67,590,841 (GRCm39) missense probably damaging 1.00
R9673:Zfp874a UTSW 13 67,591,156 (GRCm39) missense probably benign 0.03
X0063:Zfp874a UTSW 13 67,591,106 (GRCm39) missense probably damaging 1.00
Z1177:Zfp874a UTSW 13 67,590,781 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16