Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00908:Magee2'

29575

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Magee2

Ensembl Gene

ENSMUSG00000031224

Gene Name

MAGE family member E2

Synonyms

9630059J11Rik, Mage-e2

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL00908

Quality Score

Status

Chromosome

Chromosomal Location

103898558-103900873 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 103900447 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 68 (I68T)

Ref Sequence

ENSEMBL: ENSMUSP00000033575 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033575]

AlphaFold

Q52KG3

Predicted Effect

probably benign
Transcript: ENSMUST00000033575
AA Change: I68T

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000033575
Gene: ENSMUSG00000031224
AA Change: I68T

Domain	Start	End	E-Value	Type
MAGE	95	266	1.86e-57	SMART
MAGE	318	480	3.42e-47	SMART
low complexity region	500	516	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arfgap3	G	T	15: 83,206,790 (GRCm39)	P266Q	probably benign	Het
Atp6v1b2	T	A	8: 69,548,918 (GRCm39)	D61E	probably benign	Het
Cad	T	C	5: 31,216,398 (GRCm39)	I190T	possibly damaging	Het
Chd9	C	T	8: 91,723,508 (GRCm39)	T558I	probably damaging	Het
Dmkn	G	A	7: 30,477,695 (GRCm39)		probably null	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Ifi213	A	T	1: 173,422,649 (GRCm39)	V72E	probably damaging	Het
Ift122	A	G	6: 115,890,870 (GRCm39)	D803G	probably benign	Het
Il2rg	A	T	X: 100,308,454 (GRCm39)		probably benign	Het
Ing2	T	C	8: 48,122,296 (GRCm39)	Q84R	possibly damaging	Het
Kdm6a	T	C	X: 18,102,905 (GRCm39)	F211L	possibly damaging	Het
Lmnb2	T	C	10: 80,745,821 (GRCm39)	D105G	probably damaging	Het
Magi2	T	A	5: 20,596,299 (GRCm39)	D415E	probably benign	Het
Mospd2	C	T	X: 163,745,121 (GRCm39)	R135Q	probably damaging	Het
Mysm1	T	C	4: 94,847,172 (GRCm39)	D508G	probably damaging	Het
Naip2	T	C	13: 100,297,157 (GRCm39)	I960V	probably benign	Het
Ncald	C	A	15: 37,372,451 (GRCm39)	M131I	possibly damaging	Het
Nup188	T	C	2: 30,223,412 (GRCm39)	S1096P	probably damaging	Het
Plekha5	G	A	6: 140,496,656 (GRCm39)	E69K	probably damaging	Het
Ppp1cb	C	T	5: 32,635,412 (GRCm39)	R19*	probably null	Het
Rasl11b	G	A	5: 74,356,772 (GRCm39)	V50I	probably damaging	Het
Robo2	C	T	16: 73,782,579 (GRCm39)	R319K	probably damaging	Het
Trip4	T	C	9: 65,782,216 (GRCm39)	D172G	probably damaging	Het
Zc3h7a	G	A	16: 10,963,106 (GRCm39)	R752C	probably damaging	Het

Other mutations in Magee2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01700:Magee2	APN	X	103,899,574 (GRCm39)	missense	possibly damaging	0.49
IGL02377:Magee2	APN	X	103,900,399 (GRCm39)	missense	possibly damaging	0.86
IGL03231:Magee2	APN	X	103,899,944 (GRCm39)	missense	probably damaging	1.00
IGL03366:Magee2	APN	X	103,899,134 (GRCm39)	nonsense	probably null
R0741:Magee2	UTSW	X	103,899,472 (GRCm39)	missense	probably damaging	1.00
R8555:Magee2	UTSW	X	103,900,087 (GRCm39)	missense	probably damaging	1.00
X0009:Magee2	UTSW	X	103,900,448 (GRCm39)	missense	probably benign

Posted On

2013-04-17