Incidental Mutation 'IGL02498:Cracdl'
ID 295908
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cracdl
Ensembl Gene ENSMUSG00000026090
Gene Name capping protein inhibiting regulator of actin like
Synonyms 2010300C02Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02498
Quality Score
Status
Chromosome 1
Chromosomal Location 37650758-37758905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37662926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 991 (T991A)
Ref Sequence ENSEMBL: ENSMUSP00000123803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162875]
AlphaFold E9Q3M9
Predicted Effect unknown
Transcript: ENSMUST00000160023
AA Change: T466A
SMART Domains Protein: ENSMUSP00000125015
Gene: ENSMUSG00000026090
AA Change: T466A

DomainStartEndE-ValueType
internal_repeat_1 2 65 4.52e-24 PROSPERO
internal_repeat_1 65 128 4.52e-24 PROSPERO
low complexity region 181 194 N/A INTRINSIC
low complexity region 223 237 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
low complexity region 441 465 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162875
AA Change: T991A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000123803
Gene: ENSMUSG00000026090
AA Change: T991A

DomainStartEndE-ValueType
low complexity region 13 43 N/A INTRINSIC
Pfam:DUF4592 130 243 1.8e-33 PFAM
low complexity region 347 366 N/A INTRINSIC
internal_repeat_2 387 461 2.31e-5 PROSPERO
internal_repeat_3 404 474 3.67e-5 PROSPERO
internal_repeat_1 411 526 3.02e-34 PROSPERO
internal_repeat_2 485 559 2.31e-5 PROSPERO
internal_repeat_1 537 652 3.02e-34 PROSPERO
internal_repeat_3 570 698 3.67e-5 PROSPERO
low complexity region 705 718 N/A INTRINSIC
low complexity region 747 761 N/A INTRINSIC
low complexity region 787 803 N/A INTRINSIC
low complexity region 965 989 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A G 5: 99,377,236 (GRCm39) S404P probably damaging Het
A930011G23Rik G A 5: 99,377,241 (GRCm39) P402L probably damaging Het
Abcc9 A T 6: 142,617,265 (GRCm39) probably null Het
Abcg8 T C 17: 84,990,693 (GRCm39) W12R probably benign Het
Ablim1 A T 19: 57,140,751 (GRCm39) C155* probably null Het
Adam33 A G 2: 130,895,157 (GRCm39) C658R probably damaging Het
Adamts2 A G 11: 50,664,135 (GRCm39) H357R possibly damaging Het
Adamts2 G T 11: 50,668,023 (GRCm39) K528N probably damaging Het
Arhgef12 G A 9: 42,893,339 (GRCm39) P955S probably benign Het
Atp2b2 T A 6: 113,770,815 (GRCm39) I365F probably damaging Het
AW112010 T C 19: 11,025,701 (GRCm39) noncoding transcript Het
AY358078 T C 14: 52,040,944 (GRCm39) S88P probably benign Het
Cdc42bpg T C 19: 6,372,823 (GRCm39) L1504S probably benign Het
Dgkg T A 16: 22,367,441 (GRCm39) H593L probably damaging Het
Gm10463 T C 5: 32,288,742 (GRCm39) probably benign Het
Grm1 A T 10: 10,595,723 (GRCm39) L635Q probably damaging Het
Herc4 T C 10: 63,109,244 (GRCm39) C160R probably benign Het
Hs6st1 G A 1: 36,142,821 (GRCm39) R252H probably damaging Het
Litaf A G 16: 10,784,423 (GRCm39) V29A possibly damaging Het
Lmo7 G A 14: 102,044,918 (GRCm39) V57I probably benign Het
Loxl4 A T 19: 42,593,412 (GRCm39) L253Q probably benign Het
Mon2 C T 10: 122,870,235 (GRCm39) V458I probably benign Het
Ncstn G T 1: 171,896,159 (GRCm39) F506L probably benign Het
Nedd8 T A 14: 55,901,273 (GRCm39) D21V probably damaging Het
Oas1c T C 5: 120,943,591 (GRCm39) T183A possibly damaging Het
Pcsk5 A T 19: 17,488,920 (GRCm39) Y967N probably damaging Het
Phf2 A G 13: 48,958,715 (GRCm39) S936P unknown Het
Pkd1 T C 17: 24,804,753 (GRCm39) I3159T possibly damaging Het
Prrt3 C A 6: 113,474,788 (GRCm39) V145F possibly damaging Het
Prx T A 7: 27,217,497 (GRCm39) V666E probably damaging Het
Rapgef2 C T 3: 78,974,060 (GRCm39) V1577M probably damaging Het
Sesn3 T C 9: 14,217,564 (GRCm39) probably benign Het
Shoc2 T A 19: 54,016,207 (GRCm39) L407* probably null Het
Slc6a12 A G 6: 121,338,029 (GRCm39) M435V probably benign Het
Smarcc1 C T 9: 110,020,002 (GRCm39) T623I probably damaging Het
Snx14 A G 9: 88,289,517 (GRCm39) L245S probably damaging Het
Son T A 16: 91,453,713 (GRCm39) M820K probably damaging Het
Sorcs1 T C 19: 50,666,606 (GRCm39) T101A probably benign Het
Stoml2 C A 4: 43,031,045 (GRCm39) V37L probably benign Het
Syde2 T A 3: 145,704,444 (GRCm39) H465Q probably benign Het
Tmem164 T A X: 141,589,044 (GRCm39) V40D possibly damaging Het
Trim37 A G 11: 87,075,876 (GRCm39) E494G probably benign Het
Triobp A G 15: 78,845,243 (GRCm39) D195G probably benign Het
Unc79 G A 12: 103,137,837 (GRCm39) V2427M probably damaging Het
Usp27x T C X: 7,239,780 (GRCm39) probably benign Het
Vmn2r113 T A 17: 23,177,349 (GRCm39) V711D probably damaging Het
Zfp940 T C 7: 29,546,376 (GRCm39) T7A probably damaging Het
Other mutations in Cracdl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01376:Cracdl APN 1 37,667,425 (GRCm39) missense probably damaging 0.99
IGL01413:Cracdl APN 1 37,651,387 (GRCm39) missense possibly damaging 0.85
IGL01812:Cracdl APN 1 37,664,446 (GRCm39) missense probably benign 0.06
IGL02183:Cracdl APN 1 37,664,459 (GRCm39) missense possibly damaging 0.93
IGL02713:Cracdl APN 1 37,663,218 (GRCm39) missense possibly damaging 0.72
IGL02736:Cracdl APN 1 37,676,954 (GRCm39) missense probably damaging 1.00
FR4449:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4449:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4548:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4976:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0055:Cracdl UTSW 1 37,663,337 (GRCm39) missense probably benign 0.18
R0153:Cracdl UTSW 1 37,663,720 (GRCm39) missense probably benign
R0523:Cracdl UTSW 1 37,683,710 (GRCm39) start codon destroyed probably null 0.94
R0699:Cracdl UTSW 1 37,651,411 (GRCm39) missense possibly damaging 0.85
R0928:Cracdl UTSW 1 37,663,663 (GRCm39) missense possibly damaging 0.85
R1457:Cracdl UTSW 1 37,665,093 (GRCm39) nonsense probably null
R1759:Cracdl UTSW 1 37,664,791 (GRCm39) missense probably benign 0.00
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R2289:Cracdl UTSW 1 37,651,342 (GRCm39) missense possibly damaging 0.53
R2421:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2422:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2509:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2510:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2511:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R3893:Cracdl UTSW 1 37,670,539 (GRCm39) missense probably benign 0.00
R4351:Cracdl UTSW 1 37,663,993 (GRCm39) missense probably benign
R4454:Cracdl UTSW 1 37,663,834 (GRCm39) missense probably damaging 1.00
R4788:Cracdl UTSW 1 37,670,556 (GRCm39) missense probably damaging 1.00
R4798:Cracdl UTSW 1 37,664,046 (GRCm39) missense probably benign 0.12
R5599:Cracdl UTSW 1 37,652,424 (GRCm39) missense possibly damaging 0.53
R5920:Cracdl UTSW 1 37,677,062 (GRCm39) missense probably damaging 1.00
R6051:Cracdl UTSW 1 37,663,306 (GRCm39) missense probably damaging 0.98
R6106:Cracdl UTSW 1 37,652,493 (GRCm39) missense possibly damaging 0.53
R6794:Cracdl UTSW 1 37,676,936 (GRCm39) splice site probably null
R6828:Cracdl UTSW 1 37,663,898 (GRCm39) missense possibly damaging 0.53
R6930:Cracdl UTSW 1 37,664,026 (GRCm39) missense possibly damaging 0.73
R7044:Cracdl UTSW 1 37,651,361 (GRCm39) missense possibly damaging 0.85
R7069:Cracdl UTSW 1 37,670,982 (GRCm39) missense probably damaging 1.00
R7149:Cracdl UTSW 1 37,651,352 (GRCm39) nonsense probably null
R7296:Cracdl UTSW 1 37,653,699 (GRCm39) missense possibly damaging 0.53
R7698:Cracdl UTSW 1 37,664,452 (GRCm39) missense probably benign 0.12
R7714:Cracdl UTSW 1 37,663,858 (GRCm39) missense probably benign 0.33
R8071:Cracdl UTSW 1 37,663,010 (GRCm39) nonsense probably null
R8205:Cracdl UTSW 1 37,664,047 (GRCm39) missense probably benign 0.06
R8443:Cracdl UTSW 1 37,652,537 (GRCm39) missense probably benign 0.33
R8720:Cracdl UTSW 1 37,652,522 (GRCm39) missense possibly damaging 0.53
R8917:Cracdl UTSW 1 37,676,993 (GRCm39) missense probably damaging 0.99
R9056:Cracdl UTSW 1 37,663,553 (GRCm39) missense possibly damaging 0.91
R9158:Cracdl UTSW 1 37,670,442 (GRCm39) missense probably damaging 0.99
R9290:Cracdl UTSW 1 37,663,634 (GRCm39) missense probably damaging 0.97
R9483:Cracdl UTSW 1 37,670,496 (GRCm39) missense probably damaging 1.00
R9641:Cracdl UTSW 1 37,663,592 (GRCm39) missense possibly damaging 0.85
X0025:Cracdl UTSW 1 37,664,026 (GRCm39) missense probably benign 0.33
Posted On 2015-04-16