Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00963:Dock11'

29594

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dock11

Ensembl Gene

ENSMUSG00000031093

Gene Name

dedicator of cytokinesis 11

Synonyms

5033414A21Rik, Zizimin2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.217) question?

Stock #

IGL00963

Quality Score

Status

Chromosome

Chromosomal Location

35152485-35340215 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 35296035 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 1197 (Q1197R)

Ref Sequence

ENSEMBL: ENSMUSP00000110921 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115266]

AlphaFold

A2AF47

Predicted Effect

probably benign
Transcript: ENSMUST00000033419
AA Change: Q1368R

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093
AA Change: Q1368R

Domain	Start	End	E-Value	Type
Pfam:DUF3398	52	145	4.2e-39	PFAM
PH	166	274	1.4e-17	SMART
Blast:PH	329	440	4e-58	BLAST
Pfam:DOCK-C2	636	827	2.4e-53	PFAM
low complexity region	1254	1270	N/A	INTRINSIC
Pfam:DHR-2	1510	2029	7.3e-210	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000115266
AA Change: Q1197R

PolyPhen 2 Score 0.629 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093
AA Change: Q1197R

Domain	Start	End	E-Value	Type
PH	1	90	6.82e-7	SMART
Blast:PH	145	256	5e-58	BLAST
Pfam:DOCK-C2	451	644	1.3e-60	PFAM
low complexity region	1083	1099	N/A	INTRINSIC
low complexity region	1521	1529	N/A	INTRINSIC
Pfam:Ded_cyto	1681	1858	1.2e-68	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AI606181	A	C	19: 41,582,228 (GRCm39)		probably benign	Het
Alyref2	C	T	1: 171,331,816 (GRCm39)	Q198*	probably null	Het
Ankrd13a	T	C	5: 114,939,863 (GRCm39)	S497P	probably damaging	Het
Chd5	C	A	4: 152,467,395 (GRCm39)	N1644K	probably damaging	Het
Col13a1	T	C	10: 61,674,476 (GRCm39)		probably benign	Het
Ctnna3	T	A	10: 64,781,728 (GRCm39)	D730E	probably damaging	Het
Drosha	T	A	15: 12,926,083 (GRCm39)	I1224N	probably damaging	Het
Dsc1	T	C	18: 20,245,043 (GRCm39)	K42R	probably null	Het
Engase	A	G	11: 118,373,824 (GRCm39)	D322G	probably damaging	Het
Ephb2	T	C	4: 136,386,262 (GRCm39)	D829G	probably benign	Het
Fgfr2	C	T	7: 129,830,491 (GRCm39)	M47I	probably damaging	Het
Gad1-ps	G	T	10: 99,281,310 (GRCm39)		noncoding transcript	Het
Gatb	A	G	3: 85,526,255 (GRCm39)	S378G	probably benign	Het
Hivep2	G	A	10: 14,005,091 (GRCm39)	S563N	probably damaging	Het
Irs2	G	A	8: 11,055,867 (GRCm39)	A855V	probably benign	Het
Jagn1	T	C	6: 113,424,436 (GRCm39)	S103P	probably damaging	Het
Kdm6a	T	A	X: 18,112,665 (GRCm39)		probably benign	Het
Lmcd1	T	C	6: 112,306,895 (GRCm39)	C356R	probably damaging	Het
Mefv	T	A	16: 3,533,584 (GRCm39)	Y229F	possibly damaging	Het
Myef2	T	C	2: 124,957,395 (GRCm39)	Y120C	probably damaging	Het
Myo9a	T	G	9: 59,807,655 (GRCm39)	I2074S	probably damaging	Het
Nhs	A	G	X: 160,630,045 (GRCm39)	S337P	probably damaging	Het
Nphp4	T	G	4: 152,622,318 (GRCm39)	H566Q	probably benign	Het
Or2d2	A	T	7: 106,728,272 (GRCm39)	C109*	probably null	Het
Or52z13	T	A	7: 103,246,844 (GRCm39)		probably null	Het
Pabpc2	C	A	18: 39,908,390 (GRCm39)	Q552K	possibly damaging	Het
Podn	T	A	4: 107,879,371 (GRCm39)	N104I	probably damaging	Het
Rit1	T	C	3: 88,633,738 (GRCm39)	V94A	probably damaging	Het
Scn7a	A	T	2: 66,534,289 (GRCm39)		probably benign	Het
Septin4	A	T	11: 87,474,199 (GRCm39)	K29M	possibly damaging	Het
Sowahb	T	C	5: 93,191,870 (GRCm39)	Y283C	probably damaging	Het
Srbd1	A	T	17: 86,422,637 (GRCm39)	W460R	probably damaging	Het
Svep1	T	A	4: 58,072,791 (GRCm39)	K2173*	probably null	Het
Tlr6	T	C	5: 65,112,019 (GRCm39)	N296S	possibly damaging	Het
Trpm8	A	G	1: 88,307,549 (GRCm39)	D1073G	possibly damaging	Het
Ttc28	A	T	5: 111,434,255 (GRCm39)	K2399*	probably null	Het
Ttn	A	G	2: 76,717,627 (GRCm39)		probably benign	Het
Uroc1	C	T	6: 90,315,810 (GRCm39)	T189I	probably benign	Het
Usp18	C	T	6: 121,232,341 (GRCm39)	Q122*	probably null	Het
Zfp420	T	C	7: 29,574,518 (GRCm39)	I246T	probably damaging	Het
Zfp644	T	C	5: 106,786,503 (GRCm39)		probably null	Het
Zfp871	A	T	17: 32,993,726 (GRCm39)	V483E	probably benign	Het

Other mutations in Dock11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00536:Dock11	APN	X	35,258,087 (GRCm39)	missense	probably benign	0.15
IGL00650:Dock11	APN	X	35,270,246 (GRCm39)	splice site	probably benign
IGL00769:Dock11	APN	X	35,267,715 (GRCm39)	missense	possibly damaging	0.74
IGL01389:Dock11	APN	X	35,256,701 (GRCm39)	missense	probably benign	0.43
IGL01410:Dock11	APN	X	35,301,296 (GRCm39)	missense	probably damaging	1.00
IGL01519:Dock11	APN	X	35,227,006 (GRCm39)	missense	probably benign
IGL02023:Dock11	APN	X	35,232,422 (GRCm39)	missense	probably benign	0.09
IGL02253:Dock11	APN	X	35,304,781 (GRCm39)	missense	probably damaging	1.00
IGL02416:Dock11	APN	X	35,283,739 (GRCm39)	missense	probably damaging	0.97
IGL02583:Dock11	APN	X	35,270,370 (GRCm39)	missense	possibly damaging	0.48
IGL03014:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03037:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03065:Dock11	APN	X	35,310,699 (GRCm39)	splice site	probably benign
IGL03277:Dock11	APN	X	35,277,603 (GRCm39)	missense	probably benign	0.32
R0816:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R0819:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R0820:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
R1430:Dock11	UTSW	X	35,333,565 (GRCm39)	missense	probably benign	0.00
R1512:Dock11	UTSW	X	35,283,688 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock11	UTSW	X	35,266,186 (GRCm39)	missense	probably benign	0.01
Z1176:Dock11	UTSW	X	35,248,501 (GRCm39)	missense	possibly damaging	0.69

Posted On

2013-04-17