Incidental Mutation 'IGL02500:Mettl21a'
ID295990
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl21a
Ensembl Gene ENSMUSG00000025956
Gene Namemethyltransferase like 21A
Synonyms2310038H17Rik, Fam119a
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL02500
Quality Score
Status
Chromosome1
Chromosomal Location64606473-64617242 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 64608054 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 115 (Q115K)
Ref Sequence ENSEMBL: ENSMUSP00000109713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053469] [ENSMUST00000087366] [ENSMUST00000114079]
Predicted Effect probably benign
Transcript: ENSMUST00000053469
AA Change: Q115K

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000050424
Gene: ENSMUSG00000025956
AA Change: Q115K

DomainStartEndE-ValueType
Pfam:Methyltransf_16 25 190 1.8e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000087366
SMART Domains Protein: ENSMUSP00000084624
Gene: ENSMUSG00000025958

DomainStartEndE-ValueType
internal_repeat_1 16 90 1.46e-5 PROSPERO
Pfam:pKID 99 141 5.3e-24 PFAM
low complexity region 148 160 N/A INTRINSIC
internal_repeat_1 170 247 1.46e-5 PROSPERO
BRLZ 267 325 1.25e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114079
AA Change: Q115K

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000109713
Gene: ENSMUSG00000025956
AA Change: Q115K

DomainStartEndE-ValueType
Pfam:Methyltransf_16 25 190 1e-53 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162806
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 A T 14: 118,618,926 I409N possibly damaging Het
Aoc3 T A 11: 101,337,389 L674* probably null Het
Arhgef10 G A 8: 14,961,238 E265K probably damaging Het
Cd53 A G 3: 106,768,826 I75T probably damaging Het
Col26a1 A T 5: 136,754,339 L235* probably null Het
Crem G T 18: 3,273,477 Q60K probably damaging Het
Cyp2j8 T C 4: 96,470,650 D344G probably damaging Het
Cyr61 T C 3: 145,648,700 K152R probably damaging Het
Dchs1 T C 7: 105,755,806 T2510A probably benign Het
Dnajc4 T C 19: 6,988,088 Q215R possibly damaging Het
Espl1 A G 15: 102,315,800 H1262R probably benign Het
Exoc2 G T 13: 30,911,196 T239K probably damaging Het
Fzd6 A T 15: 39,031,386 S316C probably damaging Het
Htra1 A G 7: 130,984,974 K429R probably benign Het
Il1rapl2 C T X: 138,846,503 T647I possibly damaging Het
Kcnn3 T A 3: 89,661,112 probably benign Het
Kiz G A 2: 146,863,813 V98I probably benign Het
Klk1b24 A T 7: 44,188,324 probably benign Het
Lrrc30 T A 17: 67,631,862 N241I probably damaging Het
Map2k4 A G 11: 65,696,310 V288A probably damaging Het
Mefv T C 16: 3,713,577 H459R probably damaging Het
Msra A G 14: 64,285,188 probably benign Het
Myh8 G A 11: 67,305,710 R1752H probably benign Het
Nrp1 T C 8: 128,425,799 F163S possibly damaging Het
Ntng1 T A 3: 110,135,330 Y60F probably damaging Het
Pax6 G T 2: 105,692,770 R317L probably benign Het
Pcdh17 A G 14: 84,533,469 E1129G probably benign Het
Phlpp2 C T 8: 109,913,618 H472Y probably benign Het
Pip5k1c C A 10: 81,317,321 probably null Het
Prkce A G 17: 86,168,914 N108D probably benign Het
Prkdc T G 16: 15,714,282 probably null Het
Ptprm T C 17: 66,920,048 Y702C probably damaging Het
Rbbp8nl T C 2: 180,279,329 T421A possibly damaging Het
Retnlg A T 16: 48,872,960 L33F probably benign Het
Slc16a7 T A 10: 125,230,933 Y279F probably damaging Het
Slc8a1 T C 17: 81,388,713 Y964C probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Sspo C A 6: 48,478,379 C3047* probably null Het
Tmprss11b C T 5: 86,667,323 probably null Het
Txnrd1 T G 10: 82,879,217 W98G probably damaging Het
Ulk1 A T 5: 110,809,134 I66N probably damaging Het
Ush2a A G 1: 188,822,696 Y3557C probably damaging Het
Vmn2r57 T A 7: 41,428,226 H172L probably benign Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Zfp592 T A 7: 81,041,726 C1218S probably benign Het
Other mutations in Mettl21a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2219:Mettl21a UTSW 1 64616283 missense probably damaging 1.00
R2220:Mettl21a UTSW 1 64616283 missense probably damaging 1.00
R3902:Mettl21a UTSW 1 64608081 missense probably benign 0.03
R4224:Mettl21a UTSW 1 64607956 nonsense probably null
R5715:Mettl21a UTSW 1 64615155 missense probably benign 0.00
Posted On2015-04-16