Incidental Mutation 'IGL02502:Prdm15'
ID 296106
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prdm15
Ensembl Gene ENSMUSG00000014039
Gene Name PR domain containing 15
Synonyms Zfp298, E130018M06Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02502
Quality Score
Status
Chromosome 16
Chromosomal Location 97592667-97653050 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 97640539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 16 (D16G)
Ref Sequence ENSEMBL: ENSMUSP00000120497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095849] [ENSMUST00000119200] [ENSMUST00000121584] [ENSMUST00000135505] [ENSMUST00000142295]
AlphaFold E9Q8T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000095849
AA Change: D42G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000093533
Gene: ENSMUSG00000014039
AA Change: D42G

DomainStartEndE-ValueType
SET 75 191 5.96e-1 SMART
ZnF_C2H2 223 245 3.99e0 SMART
low complexity region 290 303 N/A INTRINSIC
ZnF_C2H2 402 424 3.89e-3 SMART
ZnF_C2H2 434 457 2.75e-3 SMART
ZnF_C2H2 468 488 1.88e2 SMART
ZnF_C2H2 495 517 5.42e-2 SMART
ZnF_C2H2 522 544 1.36e-2 SMART
ZnF_C2H2 571 593 6.23e-2 SMART
ZnF_C2H2 598 620 2.75e-3 SMART
low complexity region 642 657 N/A INTRINSIC
ZnF_C2H2 661 684 2.17e-1 SMART
ZnF_C2H2 689 711 3.24e0 SMART
ZnF_C2H2 725 747 1.38e-3 SMART
ZnF_C2H2 753 775 5.67e-5 SMART
ZnF_C2H2 781 803 3.11e-2 SMART
ZnF_C2H2 809 831 8.34e-3 SMART
ZnF_C2H2 837 859 4.79e-3 SMART
ZnF_C2H2 865 888 4.79e-3 SMART
ZnF_C2H2 894 917 5.06e-2 SMART
low complexity region 948 959 N/A INTRINSIC
low complexity region 1148 1170 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000119200
AA Change: D16G

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000113002
Gene: ENSMUSG00000014039
AA Change: D16G

DomainStartEndE-ValueType
PDB:3RAY|A 7 92 1e-6 PDB
Blast:SET 49 110 7e-39 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000121584
AA Change: D16G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000113791
Gene: ENSMUSG00000014039
AA Change: D16G

DomainStartEndE-ValueType
SET 49 165 5.96e-1 SMART
ZnF_C2H2 197 219 3.99e0 SMART
low complexity region 264 277 N/A INTRINSIC
ZnF_C2H2 376 398 3.89e-3 SMART
ZnF_C2H2 408 431 2.75e-3 SMART
ZnF_C2H2 442 462 1.88e2 SMART
ZnF_C2H2 469 491 5.42e-2 SMART
ZnF_C2H2 496 518 1.36e-2 SMART
ZnF_C2H2 545 567 6.23e-2 SMART
ZnF_C2H2 572 594 2.75e-3 SMART
low complexity region 616 631 N/A INTRINSIC
ZnF_C2H2 635 658 2.17e-1 SMART
ZnF_C2H2 663 685 3.24e0 SMART
ZnF_C2H2 699 721 1.38e-3 SMART
ZnF_C2H2 727 749 5.67e-5 SMART
ZnF_C2H2 755 777 3.11e-2 SMART
ZnF_C2H2 783 805 8.34e-3 SMART
ZnF_C2H2 811 833 4.79e-3 SMART
ZnF_C2H2 839 862 4.79e-3 SMART
ZnF_C2H2 868 891 5.06e-2 SMART
low complexity region 922 933 N/A INTRINSIC
low complexity region 1122 1144 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129331
Predicted Effect possibly damaging
Transcript: ENSMUST00000135505
AA Change: D42G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect probably damaging
Transcript: ENSMUST00000142295
AA Change: D16G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000120497
Gene: ENSMUSG00000014039
AA Change: D16G

DomainStartEndE-ValueType
SET 49 165 5.96e-1 SMART
low complexity region 230 243 N/A INTRINSIC
ZnF_C2H2 342 364 3.89e-3 SMART
ZnF_C2H2 369 392 2.75e-3 SMART
ZnF_C2H2 403 423 1.88e2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acoxl A G 2: 127,917,804 (GRCm39) N216S probably damaging Het
Akap12 A G 10: 4,303,163 (GRCm39) D96G probably damaging Het
Akna A G 4: 63,286,440 (GRCm39) V1353A probably benign Het
Ambra1 A G 2: 91,730,877 (GRCm39) D914G probably damaging Het
Ap1s3 A G 1: 79,601,439 (GRCm39) V84A possibly damaging Het
Arhgef6 T C X: 56,325,623 (GRCm39) E282G probably damaging Het
C2cd2 G T 16: 97,677,590 (GRCm39) S378Y possibly damaging Het
Cd101 C A 3: 100,919,141 (GRCm39) A654S probably damaging Het
Cep295 A C 9: 15,262,209 (GRCm39) probably benign Het
Csn1s1 A G 5: 87,828,784 (GRCm39) I283V probably benign Het
Cst3 A G 2: 148,717,065 (GRCm39) probably benign Het
Cyp2b9 T C 7: 25,887,239 (GRCm39) probably null Het
Dffb A G 4: 154,050,073 (GRCm39) probably benign Het
Dnah10 A G 5: 124,898,351 (GRCm39) Y3711C probably damaging Het
Eif4g2 T C 7: 110,680,748 (GRCm39) S3G probably damaging Het
Erbb3 C T 10: 128,406,153 (GRCm39) R1088H probably benign Het
Evpl T C 11: 116,113,544 (GRCm39) D1382G probably damaging Het
Fam168a A G 7: 100,473,417 (GRCm39) D102G probably damaging Het
Fbxo7 A G 10: 85,869,161 (GRCm39) Y284C probably damaging Het
G6pd2 T C 5: 61,966,971 (GRCm39) Y249H probably damaging Het
Gm1123 A T 9: 98,891,443 (GRCm39) Y335* probably null Het
Gm5624 C T 14: 44,797,296 (GRCm39) probably null Het
Hectd1 A T 12: 51,844,635 (GRCm39) M536K possibly damaging Het
Ikbkg T A X: 73,487,433 (GRCm39) V334E probably benign Het
Ipo7 T C 7: 109,650,257 (GRCm39) L769P probably damaging Het
Jmjd1c A T 10: 67,061,640 (GRCm39) K1331I probably benign Het
Krt32 T C 11: 99,978,749 (GRCm39) K102E probably damaging Het
Lrrc34 A T 3: 30,699,394 (GRCm39) N20K probably benign Het
Lrrc47 A G 4: 154,100,471 (GRCm39) E349G probably benign Het
Mdn1 A G 4: 32,670,579 (GRCm39) I415V possibly damaging Het
Myh10 A G 11: 68,705,198 (GRCm39) probably null Het
Nbeal2 A G 9: 110,462,836 (GRCm39) S1376P probably damaging Het
Nfx1 T C 4: 40,976,345 (GRCm39) probably benign Het
Nherf4 G A 9: 44,160,948 (GRCm39) A206V probably benign Het
Notch3 A T 17: 32,377,252 (GRCm39) C246* probably null Het
Nr3c2 A G 8: 77,969,143 (GRCm39) Y976C probably damaging Het
Or51b17 A G 7: 103,542,696 (GRCm39) V82A probably damaging Het
Or52n4b T A 7: 108,143,846 (GRCm39) M36K probably damaging Het
Or5b122 A G 19: 13,563,112 (GRCm39) Y105C probably damaging Het
P2rx7 C T 5: 122,819,050 (GRCm39) R491C possibly damaging Het
Phex T A X: 155,966,823 (GRCm39) Y625F possibly damaging Het
Pkhd1 T C 1: 20,462,389 (GRCm39) D2055G probably damaging Het
Pmm2 T C 16: 8,463,227 (GRCm39) probably benign Het
Prune2 T A 19: 17,101,245 (GRCm39) C2250S probably benign Het
Rasgef1a T A 6: 118,057,443 (GRCm39) F48Y probably benign Het
Rhoq T C 17: 87,271,077 (GRCm39) V15A probably damaging Het
Rnf216 G A 5: 143,054,622 (GRCm39) A585V probably damaging Het
Septin9 T A 11: 117,181,488 (GRCm39) I96N probably damaging Het
Shprh T A 10: 11,070,101 (GRCm39) D1492E possibly damaging Het
Slc22a26 A T 19: 7,768,125 (GRCm39) probably null Het
Tek T G 4: 94,741,818 (GRCm39) probably null Het
Tenm3 T C 8: 48,741,051 (GRCm39) E782G probably damaging Het
Trmt5 A G 12: 73,328,001 (GRCm39) C401R probably benign Het
Tspear T G 10: 77,688,792 (GRCm39) probably benign Het
Ubr5 G A 15: 38,030,933 (GRCm39) T414I probably benign Het
Vcl A T 14: 21,069,453 (GRCm39) T710S probably damaging Het
Vmn2r25 A T 6: 123,816,392 (GRCm39) D396E probably damaging Het
Wtip A G 7: 33,818,094 (GRCm39) probably null Het
Zap70 A G 1: 36,817,887 (GRCm39) probably benign Het
Other mutations in Prdm15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00973:Prdm15 APN 16 97,607,367 (GRCm39) splice site probably benign
IGL01325:Prdm15 APN 16 97,607,717 (GRCm39) missense probably damaging 1.00
IGL02195:Prdm15 APN 16 97,637,029 (GRCm39) missense probably damaging 1.00
IGL02473:Prdm15 APN 16 97,638,805 (GRCm39) splice site probably null
IGL02604:Prdm15 APN 16 97,623,142 (GRCm39) missense probably benign
R0408:Prdm15 UTSW 16 97,636,986 (GRCm39) missense possibly damaging 0.92
R0437:Prdm15 UTSW 16 97,613,759 (GRCm39) missense probably benign 0.00
R0497:Prdm15 UTSW 16 97,595,534 (GRCm39) missense possibly damaging 0.63
R0590:Prdm15 UTSW 16 97,598,961 (GRCm39) missense possibly damaging 0.95
R0630:Prdm15 UTSW 16 97,638,907 (GRCm39) missense probably null 1.00
R0661:Prdm15 UTSW 16 97,630,882 (GRCm39) missense probably benign 0.34
R0718:Prdm15 UTSW 16 97,613,833 (GRCm39) missense possibly damaging 0.89
R1144:Prdm15 UTSW 16 97,609,908 (GRCm39) missense probably damaging 1.00
R1240:Prdm15 UTSW 16 97,638,800 (GRCm39) missense probably damaging 0.98
R1605:Prdm15 UTSW 16 97,640,506 (GRCm39) missense probably damaging 1.00
R1908:Prdm15 UTSW 16 97,638,885 (GRCm39) missense probably benign 0.27
R2081:Prdm15 UTSW 16 97,604,980 (GRCm39) nonsense probably null
R2208:Prdm15 UTSW 16 97,600,464 (GRCm39) splice site probably null
R3787:Prdm15 UTSW 16 97,598,945 (GRCm39) missense probably benign 0.00
R3890:Prdm15 UTSW 16 97,600,771 (GRCm39) missense probably damaging 1.00
R4326:Prdm15 UTSW 16 97,607,715 (GRCm39) missense probably damaging 1.00
R4728:Prdm15 UTSW 16 97,622,986 (GRCm39) missense probably benign 0.04
R4952:Prdm15 UTSW 16 97,607,277 (GRCm39) missense probably damaging 0.99
R4998:Prdm15 UTSW 16 97,595,689 (GRCm39) missense probably damaging 0.97
R5225:Prdm15 UTSW 16 97,609,875 (GRCm39) missense probably damaging 1.00
R5505:Prdm15 UTSW 16 97,618,183 (GRCm39) missense possibly damaging 0.76
R5628:Prdm15 UTSW 16 97,600,823 (GRCm39) missense probably damaging 0.98
R5721:Prdm15 UTSW 16 97,608,296 (GRCm39) missense possibly damaging 0.74
R5873:Prdm15 UTSW 16 97,609,889 (GRCm39) missense probably damaging 1.00
R5980:Prdm15 UTSW 16 97,613,770 (GRCm39) nonsense probably null
R6311:Prdm15 UTSW 16 97,600,255 (GRCm39) missense probably null 0.08
R6540:Prdm15 UTSW 16 97,637,005 (GRCm39) missense probably benign 0.13
R7053:Prdm15 UTSW 16 97,595,742 (GRCm39) nonsense probably null
R7241:Prdm15 UTSW 16 97,596,941 (GRCm39) missense possibly damaging 0.50
R7468:Prdm15 UTSW 16 97,636,842 (GRCm39) nonsense probably null
R7473:Prdm15 UTSW 16 97,623,046 (GRCm39) missense possibly damaging 0.68
R7762:Prdm15 UTSW 16 97,619,473 (GRCm39) missense probably benign 0.00
R7911:Prdm15 UTSW 16 97,613,792 (GRCm39) missense probably benign 0.35
R8053:Prdm15 UTSW 16 97,636,807 (GRCm39) missense probably benign 0.17
R8127:Prdm15 UTSW 16 97,638,910 (GRCm39) missense probably benign 0.24
R8213:Prdm15 UTSW 16 97,608,260 (GRCm39) missense probably damaging 1.00
R8708:Prdm15 UTSW 16 97,618,066 (GRCm39) missense unknown
R8768:Prdm15 UTSW 16 97,638,888 (GRCm39) missense probably benign
R9000:Prdm15 UTSW 16 97,595,470 (GRCm39) missense probably benign 0.03
R9513:Prdm15 UTSW 16 97,607,704 (GRCm39) missense probably damaging 1.00
R9583:Prdm15 UTSW 16 97,623,142 (GRCm39) missense probably benign
RF002:Prdm15 UTSW 16 97,600,829 (GRCm39) missense probably damaging 1.00
RF021:Prdm15 UTSW 16 97,609,956 (GRCm39) missense probably damaging 1.00
Z1177:Prdm15 UTSW 16 97,618,159 (GRCm39) missense possibly damaging 0.54
Posted On 2015-04-16