Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02506:Zfp663'

296335

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp663

Ensembl Gene

ENSMUSG00000056824

Gene Name

zinc finger protein 663

Synonyms

LOC381405, Gm1008

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL02506

Quality Score

Status

Chromosome

Chromosomal Location

165193217-165210649 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 165195871 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 116 (V116D)

Ref Sequence

ENSEMBL: ENSMUSP00000099374 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073062] [ENSMUST00000103085] [ENSMUST00000141140]

AlphaFold

Q6NXM6

Predicted Effect

probably benign
Transcript: ENSMUST00000073062
AA Change: V116D

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000072813
Gene: ENSMUSG00000056824
AA Change: V116D

Domain	Start	End	E-Value	Type
KRAB	8	68	1.97e-31	SMART
ZnF_C2H2	205	227	3.47e1	SMART
ZnF_C2H2	472	494	2.4e-3	SMART
ZnF_C2H2	500	522	2.99e-4	SMART
ZnF_C2H2	528	550	2.43e-4	SMART
ZnF_C2H2	556	578	4.79e-3	SMART
ZnF_C2H2	584	606	3.95e-4	SMART
ZnF_C2H2	612	635	8.6e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000103085
AA Change: V116D

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000099374
Gene: ENSMUSG00000056824
AA Change: V116D

Domain	Start	End	E-Value	Type
KRAB	8	68	1.97e-31	SMART
ZnF_C2H2	205	227	3.47e1	SMART
ZnF_C2H2	472	494	2.4e-3	SMART
ZnF_C2H2	500	522	2.99e-4	SMART
ZnF_C2H2	528	550	2.43e-4	SMART
ZnF_C2H2	556	578	4.79e-3	SMART
ZnF_C2H2	584	606	3.95e-4	SMART
ZnF_C2H2	612	635	8.6e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136482

Predicted Effect

probably benign
Transcript: ENSMUST00000141140

SMART Domains

Protein: ENSMUSP00000115254
Gene: ENSMUSG00000056824

Domain	Start	End	E-Value	Type
KRAB	8	68	1.97e-31	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg8	A	G	17: 84,999,916 (GRCm39)	E189G	possibly damaging	Het
Acad11	T	C	9: 103,968,931 (GRCm39)		probably null	Het
Adcy7	G	T	8: 89,044,571 (GRCm39)	R488L	probably damaging	Het
Akt1	C	T	12: 112,625,714 (GRCm39)		probably benign	Het
Ano9	C	T	7: 140,682,167 (GRCm39)		probably benign	Het
Arhgap15	A	G	2: 43,953,820 (GRCm39)	D182G	possibly damaging	Het
Asxl3	T	A	18: 22,585,456 (GRCm39)	V127D	probably benign	Het
Cacna1g	A	G	11: 94,319,955 (GRCm39)	M1407T	probably damaging	Het
Card9	A	C	2: 26,244,427 (GRCm39)		probably benign	Het
Cdh5	A	G	8: 104,864,454 (GRCm39)	N472D	probably damaging	Het
Ceacam2	T	A	7: 25,227,379 (GRCm39)	T343S	probably benign	Het
Cic	T	A	7: 24,990,282 (GRCm39)	C1928S	probably benign	Het
Clk3	C	T	9: 57,661,927 (GRCm39)	W31*	probably null	Het
Cntn4	A	G	6: 106,595,349 (GRCm39)	T489A	probably benign	Het
Crispld1	G	A	1: 17,826,529 (GRCm39)	R431H	probably damaging	Het
Crmp1	T	A	5: 37,436,199 (GRCm39)		probably benign	Het
Cyld	A	G	8: 89,456,218 (GRCm39)	T423A	possibly damaging	Het
Cyp3a44	A	T	5: 145,736,198 (GRCm39)	I84N	probably damaging	Het
D2hgdh	A	G	1: 93,757,507 (GRCm39)	N141D	probably damaging	Het
Dip2b	T	A	15: 100,055,162 (GRCm39)	L341Q	probably damaging	Het
F3	C	T	3: 121,525,323 (GRCm39)	T53I	possibly damaging	Het
Fam227b	T	A	2: 125,845,831 (GRCm39)	Y386F	probably benign	Het
Fmn1	A	T	2: 113,355,640 (GRCm39)	T694S	unknown	Het
Gcnt2	T	A	13: 41,040,856 (GRCm39)	V5E	probably benign	Het
Herpud1	G	T	8: 95,121,270 (GRCm39)	E355*	probably null	Het
Igf1r	T	C	7: 67,843,144 (GRCm39)	S752P	probably benign	Het
Iqsec1	T	C	6: 90,649,057 (GRCm39)	I687V	possibly damaging	Het
Kdm5a	T	C	6: 120,409,110 (GRCm39)	S1598P	probably damaging	Het
Klk1b9	A	G	7: 43,445,063 (GRCm39)	E185G	probably benign	Het
Myo16	G	T	8: 10,440,217 (GRCm39)	R423L	probably damaging	Het
Myo7b	T	C	18: 32,100,207 (GRCm39)	E1609G	probably damaging	Het
Nom1	T	A	5: 29,644,814 (GRCm39)		probably benign	Het
Nomo1	A	G	7: 45,727,480 (GRCm39)	I1040V	possibly damaging	Het
Or8b39	G	A	9: 37,996,741 (GRCm39)	G203D	probably damaging	Het
Paqr9	T	C	9: 95,442,748 (GRCm39)	V246A	probably benign	Het
Pfkfb4	A	T	9: 108,859,404 (GRCm39)	D437V	probably benign	Het
Phldb1	G	T	9: 44,622,223 (GRCm39)	D797E	probably benign	Het
Pkd1l3	A	G	8: 110,374,132 (GRCm39)	E1399G	probably damaging	Het
Plekhs1	G	A	19: 56,460,198 (GRCm39)	C97Y	probably damaging	Het
Plscr4	A	T	9: 92,372,044 (GRCm39)	I272L	possibly damaging	Het
Prlhr	A	C	19: 60,456,366 (GRCm39)	Y67D	probably damaging	Het
Rab3gap2	A	G	1: 184,984,221 (GRCm39)		probably benign	Het
Rad23b	T	C	4: 55,382,511 (GRCm39)	V238A	probably benign	Het
Sel1l2	T	C	2: 140,117,380 (GRCm39)	T164A	possibly damaging	Het
Serpinh1	T	A	7: 98,996,199 (GRCm39)	K295M	probably damaging	Het
Slc45a4	T	C	15: 73,453,687 (GRCm39)	E770G	probably benign	Het
Spag4	T	C	2: 155,911,142 (GRCm39)	L390P	probably damaging	Het
Stip1	A	G	19: 7,012,857 (GRCm39)		probably benign	Het
Tacr1	A	G	6: 82,380,739 (GRCm39)	N50S	probably damaging	Het
Tg	T	C	15: 66,613,443 (GRCm39)	V433A	possibly damaging	Het
Ubap1l	T	A	9: 65,276,493 (GRCm39)		probably benign	Het
Usp40	A	T	1: 87,909,738 (GRCm39)	I572K	probably damaging	Het
Vps13b	G	T	15: 35,917,308 (GRCm39)	E3717D	probably damaging	Het
Wdr81	T	C	11: 75,335,232 (GRCm39)	N1778S	probably benign	Het
Ylpm1	T	A	12: 85,095,965 (GRCm39)	F1162Y	probably damaging	Het
Zbtb10	T	A	3: 9,330,297 (GRCm39)	F552I	probably damaging	Het
Zfp507	T	C	7: 35,475,891 (GRCm39)	I811V	probably damaging	Het

Other mutations in Zfp663

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Zfp663	APN	2	165,194,525 (GRCm39)	missense	probably damaging	1.00
IGL01382:Zfp663	APN	2	165,200,935 (GRCm39)	missense	probably damaging	1.00
IGL02007:Zfp663	APN	2	165,200,993 (GRCm39)	missense	probably benign	0.12
IGL02164:Zfp663	APN	2	165,200,968 (GRCm39)	nonsense	probably null
IGL03173:Zfp663	APN	2	165,194,419 (GRCm39)	missense	probably damaging	0.99
R0735:Zfp663	UTSW	2	165,200,995 (GRCm39)	missense	probably damaging	0.97
R1395:Zfp663	UTSW	2	165,194,492 (GRCm39)	missense	probably damaging	1.00
R1402:Zfp663	UTSW	2	165,195,890 (GRCm39)	missense	probably benign	0.14
R1402:Zfp663	UTSW	2	165,195,890 (GRCm39)	missense	probably benign	0.14
R1503:Zfp663	UTSW	2	165,194,573 (GRCm39)	missense	probably damaging	0.99
R1587:Zfp663	UTSW	2	165,195,437 (GRCm39)	missense	probably benign
R1854:Zfp663	UTSW	2	165,195,211 (GRCm39)	missense	probably benign	0.18
R1867:Zfp663	UTSW	2	165,194,651 (GRCm39)	missense	possibly damaging	0.74
R3031:Zfp663	UTSW	2	165,195,616 (GRCm39)	nonsense	probably null
R4643:Zfp663	UTSW	2	165,194,925 (GRCm39)	missense	probably benign	0.24
R4691:Zfp663	UTSW	2	165,201,050 (GRCm39)	intron	probably benign
R4977:Zfp663	UTSW	2	165,195,731 (GRCm39)	missense	probably damaging	0.97
R5135:Zfp663	UTSW	2	165,195,590 (GRCm39)	missense	possibly damaging	0.95
R5151:Zfp663	UTSW	2	165,195,113 (GRCm39)	missense	probably benign	0.00
R5639:Zfp663	UTSW	2	165,194,929 (GRCm39)	missense	probably benign	0.03
R5763:Zfp663	UTSW	2	165,200,355 (GRCm39)	nonsense	probably null
R6776:Zfp663	UTSW	2	165,200,935 (GRCm39)	missense	probably damaging	1.00
R6929:Zfp663	UTSW	2	165,195,178 (GRCm39)	missense	probably benign
R6998:Zfp663	UTSW	2	165,195,922 (GRCm39)	missense	possibly damaging	0.74
R7035:Zfp663	UTSW	2	165,195,023 (GRCm39)	missense	probably benign	0.36
R7169:Zfp663	UTSW	2	165,194,359 (GRCm39)	missense	probably benign	0.00
R7529:Zfp663	UTSW	2	165,194,728 (GRCm39)	missense	probably damaging	1.00
R7790:Zfp663	UTSW	2	165,194,453 (GRCm39)	missense	probably damaging	1.00
R8087:Zfp663	UTSW	2	165,195,679 (GRCm39)	missense	probably benign	0.20
R8715:Zfp663	UTSW	2	165,194,644 (GRCm39)	missense	probably damaging	1.00
R8934:Zfp663	UTSW	2	165,194,714 (GRCm39)	missense	probably damaging	1.00
R8966:Zfp663	UTSW	2	165,194,958 (GRCm39)	missense	probably damaging	1.00
R9257:Zfp663	UTSW	2	165,195,974 (GRCm39)	missense	probably benign	0.00
R9278:Zfp663	UTSW	2	165,202,010 (GRCm39)	critical splice acceptor site	probably null
R9524:Zfp663	UTSW	2	165,195,607 (GRCm39)	missense	probably damaging	0.99
RF004:Zfp663	UTSW	2	165,200,363 (GRCm39)	missense	probably benign	0.00
Z1177:Zfp663	UTSW	2	165,195,033 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16