Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02507:Cgrrf1'

296381

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cgrrf1

Ensembl Gene

ENSMUSG00000055128

Gene Name

cell growth regulator with ring finger domain 1

Synonyms

CGR19, 1110038G02Rik, 1810009H17Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02507

Quality Score

Status

Chromosome

Chromosomal Location

47069591-47091655 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 47090901 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 212 (Y212*)

Ref Sequence

ENSEMBL: ENSMUSP00000070548 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068532] [ENSMUST00000226861]

AlphaFold

Q8BMJ7

Predicted Effect

probably null
Transcript: ENSMUST00000068532
AA Change: Y212*

SMART Domains

Protein: ENSMUSP00000070548
Gene: ENSMUSG00000055128
AA Change: Y212*

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	233	246	N/A	INTRINSIC
RING	274	308	2.26e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000226861

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,349,388 (GRCm39)	Y3654C	probably damaging	Het
Aldh1l2	A	C	10: 83,328,448 (GRCm39)	Y756*	probably null	Het
Arhgef12	T	C	9: 42,903,859 (GRCm39)	E733G	probably damaging	Het
Art5	A	T	7: 101,748,699 (GRCm39)	M1K	probably null	Het
Atp1a2	A	T	1: 172,113,338 (GRCm39)	D448E	probably damaging	Het
Atp6v1b1	C	T	6: 83,733,837 (GRCm39)	T356I	possibly damaging	Het
Celsr1	A	G	15: 85,784,889 (GRCm39)		probably benign	Het
Cep89	A	G	7: 35,134,990 (GRCm39)	Y686C	probably damaging	Het
Chrnb1	T	C	11: 69,675,916 (GRCm39)	Y442C	probably damaging	Het
Clcn1	T	C	6: 42,284,007 (GRCm39)		probably benign	Het
Clcn7	G	A	17: 25,363,443 (GRCm39)	V40M	probably damaging	Het
Cntn1	A	G	15: 92,148,860 (GRCm39)	Y369C	possibly damaging	Het
Csmd1	T	C	8: 17,584,992 (GRCm39)		probably benign	Het
Dpy19l2	A	T	9: 24,542,563 (GRCm39)	C446S	probably benign	Het
Edem3	G	A	1: 151,687,407 (GRCm39)	E782K	probably benign	Het
Efcab15	T	A	11: 103,090,275 (GRCm39)	Q287L	probably damaging	Het
Ephb3	T	A	16: 21,039,389 (GRCm39)		probably benign	Het
Fndc4	T	C	5: 31,452,090 (GRCm39)	D109G	probably damaging	Het
Fras1	T	C	5: 96,805,267 (GRCm39)	V1303A	possibly damaging	Het
Gcn1	T	C	5: 115,723,940 (GRCm39)	L532P	probably benign	Het
Gm5150	A	G	3: 16,017,485 (GRCm39)	L262P	probably damaging	Het
Hbb-bs	T	C	7: 103,477,091 (GRCm39)		probably benign	Het
Krt74	A	G	15: 101,669,059 (GRCm39)		noncoding transcript	Het
Myo1a	T	C	10: 127,548,478 (GRCm39)	V375A	probably damaging	Het
Nup160	A	T	2: 90,560,079 (GRCm39)	Q1268L	probably benign	Het
Or4k42	G	A	2: 111,319,768 (GRCm39)	T245M	possibly damaging	Het
Or51ag1	G	T	7: 103,155,925 (GRCm39)	S76*	probably null	Het
Or5d16	G	A	2: 87,773,262 (GRCm39)	R237*	probably null	Het
Or9s27	T	C	1: 92,516,648 (GRCm39)	S199P	possibly damaging	Het
Pan3	T	C	5: 147,463,406 (GRCm39)	S497P	probably damaging	Het
Pex5	T	C	6: 124,390,264 (GRCm39)	T138A	probably benign	Het
Pik3ap1	A	G	19: 41,270,451 (GRCm39)		probably benign	Het
Ptchd4	A	T	17: 42,627,764 (GRCm39)	H75L	possibly damaging	Het
Rag2	A	T	2: 101,461,055 (GRCm39)	H455L	probably damaging	Het
Rergl	T	A	6: 139,470,351 (GRCm39)	E159V	probably damaging	Het
Rrn3	A	G	16: 13,606,721 (GRCm39)	N109S	probably benign	Het
Scn1a	A	T	2: 66,108,157 (GRCm39)	V1523D	probably damaging	Het
Sec23a	A	G	12: 59,053,884 (GRCm39)	V38A	probably benign	Het
Slc15a2	G	A	16: 36,602,021 (GRCm39)	T92M	possibly damaging	Het
Slc2a2	A	G	3: 28,781,260 (GRCm39)	T433A	probably benign	Het
Sptan1	A	G	2: 29,906,067 (GRCm39)	D1671G	probably damaging	Het
Stab1	A	G	14: 30,861,167 (GRCm39)		probably benign	Het
Stau2	A	T	1: 16,556,293 (GRCm39)	I22N	possibly damaging	Het
Strn3	A	T	12: 51,708,410 (GRCm39)	Y123*	probably null	Het
Tmem205	A	G	9: 21,837,607 (GRCm39)	V13A	possibly damaging	Het
Trub1	G	A	19: 57,472,009 (GRCm39)		probably benign	Het
Ttn	A	G	2: 76,568,699 (GRCm39)	V27398A	possibly damaging	Het
Vill	A	G	9: 118,899,845 (GRCm39)	E343G	possibly damaging	Het
Zgpat	T	C	2: 181,008,029 (GRCm39)	F189L	probably damaging	Het

Other mutations in Cgrrf1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Cgrrf1	APN	14	47,069,779 (GRCm39)	missense	probably damaging	0.99
IGL03298:Cgrrf1	APN	14	47,083,778 (GRCm39)	missense	probably benign	0.08
R0152:Cgrrf1	UTSW	14	47,091,370 (GRCm39)	missense	probably damaging	1.00
R1477:Cgrrf1	UTSW	14	47,090,895 (GRCm39)	missense	probably benign	0.12
R2020:Cgrrf1	UTSW	14	47,067,902 (GRCm39)	unclassified	probably benign
R2107:Cgrrf1	UTSW	14	47,090,833 (GRCm39)	splice site	probably benign
R3010:Cgrrf1	UTSW	14	47,091,223 (GRCm39)	missense	probably benign
R3801:Cgrrf1	UTSW	14	47,069,820 (GRCm39)	missense	probably damaging	1.00
R4296:Cgrrf1	UTSW	14	47,069,812 (GRCm39)	missense	probably damaging	0.99
R4681:Cgrrf1	UTSW	14	47,091,283 (GRCm39)	missense	probably benign	0.00
R4884:Cgrrf1	UTSW	14	47,090,912 (GRCm39)	missense	possibly damaging	0.82
R6010:Cgrrf1	UTSW	14	47,091,158 (GRCm39)	missense	probably damaging	0.99
R6299:Cgrrf1	UTSW	14	47,077,647 (GRCm39)	missense	probably damaging	1.00
R6861:Cgrrf1	UTSW	14	47,069,785 (GRCm39)	missense	probably damaging	1.00
R6932:Cgrrf1	UTSW	14	47,091,179 (GRCm39)	missense	probably benign	0.09
R6986:Cgrrf1	UTSW	14	47,069,586 (GRCm39)	unclassified	probably benign
R7132:Cgrrf1	UTSW	14	47,091,321 (GRCm39)	missense	probably damaging	1.00
R7152:Cgrrf1	UTSW	14	47,090,934 (GRCm39)	nonsense	probably null
R7694:Cgrrf1	UTSW	14	47,091,415 (GRCm39)	missense	possibly damaging	0.79
R8081:Cgrrf1	UTSW	14	47,091,468 (GRCm39)	missense	probably benign	0.03
R8158:Cgrrf1	UTSW	14	47,091,192 (GRCm39)	missense	probably benign	0.00
R9028:Cgrrf1	UTSW	14	47,091,200 (GRCm39)	missense	probably benign	0.01
R9430:Cgrrf1	UTSW	14	47,091,331 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16