Incidental Mutation 'IGL02513:Gpr152'
ID296628
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr152
Ensembl Gene ENSMUSG00000044724
Gene NameG protein-coupled receptor 152
SynonymsA930009H15Rik, LOC269053
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.037) question?
Stock #IGL02513
Quality Score
Status
Chromosome19
Chromosomal Location4139799-4145738 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 4142844 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 128 (D128G)
Ref Sequence ENSEMBL: ENSMUSP00000094062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025761] [ENSMUST00000096338]
Predicted Effect probably benign
Transcript: ENSMUST00000025761
SMART Domains Protein: ENSMUSP00000025761
Gene: ENSMUSG00000024842

DomainStartEndE-ValueType
low complexity region 45 67 N/A INTRINSIC
low complexity region 79 97 N/A INTRINSIC
EFh 129 157 1.08e-6 SMART
Blast:EFh 165 193 2e-7 BLAST
EFh 206 234 1.05e-4 SMART
EFh 243 271 1.55e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000096338
AA Change: D128G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000094062
Gene: ENSMUSG00000044724
AA Change: D128G

DomainStartEndE-ValueType
Pfam:7tm_1 47 295 7e-19 PFAM
low complexity region 347 361 N/A INTRINSIC
low complexity region 419 433 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apob G T 12: 7,992,979 V787F probably benign Het
Atg14 T C 14: 47,548,994 I268V probably benign Het
Atg14 T A 14: 47,545,624 probably benign Het
Atm A T 9: 53,497,262 probably benign Het
Atp5s A T 12: 69,741,045 Y85F probably benign Het
Ccdc9 A G 7: 16,284,509 probably benign Het
Cers6 T C 2: 69,068,669 F217S probably benign Het
Crebbp A C 16: 4,126,605 probably null Het
Csmd1 T A 8: 15,999,869 probably benign Het
Eml1 T A 12: 108,530,312 V609E probably damaging Het
Fam155a T A 8: 9,207,930 D406V probably benign Het
Fryl A G 5: 73,065,293 S204P probably damaging Het
Itgal T A 7: 127,328,672 V1013D possibly damaging Het
Kctd18 A G 1: 57,965,400 Y112H probably damaging Het
Kdm4d T A 9: 14,464,554 T3S probably benign Het
Lrp1b C T 2: 41,110,753 probably null Het
Mex3c T A 18: 73,590,289 D484E possibly damaging Het
Nat14 T C 7: 4,924,051 V74A possibly damaging Het
Olfr11 A G 13: 21,639,340 F61S probably damaging Het
Pabpc2 C T 18: 39,775,140 T486I probably benign Het
Pgm1 A G 5: 64,102,946 probably benign Het
Pkn3 T A 2: 30,083,137 I353N probably damaging Het
Rbm44 T A 1: 91,155,538 S594R possibly damaging Het
Rrbp1 C T 2: 143,988,430 A606T possibly damaging Het
Tcof1 A G 18: 60,831,778 V623A possibly damaging Het
Tg A G 15: 66,705,274 E1482G probably benign Het
Uba1 A G X: 20,675,646 T546A probably benign Het
Vmn2r37 T C 7: 9,217,935 K310E probably benign Het
Zbtb38 A T 9: 96,687,073 W653R probably damaging Het
Zdhhc19 A T 16: 32,499,622 I99F probably damaging Het
Zfp236 T C 18: 82,630,114 Y974C probably damaging Het
Other mutations in Gpr152
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Gpr152 APN 19 4143507 missense probably benign
IGL01400:Gpr152 APN 19 4143627 missense probably benign 0.33
IGL01538:Gpr152 APN 19 4142952 missense probably damaging 1.00
IGL02288:Gpr152 APN 19 4143695 missense probably benign
IGL03335:Gpr152 APN 19 4143771 missense possibly damaging 0.69
R0318:Gpr152 UTSW 19 4143542 missense possibly damaging 0.73
R1216:Gpr152 UTSW 19 4143555 missense possibly damaging 0.86
R1936:Gpr152 UTSW 19 4142532 missense probably damaging 1.00
R2248:Gpr152 UTSW 19 4143806 missense probably benign 0.00
R3161:Gpr152 UTSW 19 4142714 missense probably benign 0.00
R4193:Gpr152 UTSW 19 4142907 missense probably damaging 1.00
R4719:Gpr152 UTSW 19 4143224 missense possibly damaging 0.92
R4852:Gpr152 UTSW 19 4143791 missense probably benign 0.00
R5014:Gpr152 UTSW 19 4143507 missense probably benign 0.00
R5381:Gpr152 UTSW 19 4142517 missense probably damaging 1.00
R5431:Gpr152 UTSW 19 4143747 missense probably benign 0.21
R5470:Gpr152 UTSW 19 4143129 missense probably damaging 1.00
Posted On2015-04-16