Incidental Mutation 'IGL02513:Vmn2r37'
| ID |
296636 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r37
|
| Ensembl Gene |
ENSMUSG00000066828 |
| Gene Name |
vomeronasal 2, receptor 37 |
| Synonyms |
V2r14 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
IGL02513
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
9208548-9226652 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 9220934 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 310
(K310E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072566
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072787]
|
| AlphaFold |
F8VQD3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072787
AA Change: K310E
PolyPhen 2
Score 0.138 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000072566
Gene: ENSMUSG00000066828
AA Change: K310E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
157 |
469 |
2.9e-26 |
PFAM |
|
Pfam:NCD3G
|
512 |
563 |
1.1e-16 |
PFAM |
|
Pfam:7tm_3
|
550 |
783 |
1.7e-53 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apob |
G |
T |
12: 8,042,979 (GRCm39) |
V787F |
probably benign |
Het |
| Atg14 |
T |
C |
14: 47,786,451 (GRCm39) |
I268V |
probably benign |
Het |
| Atg14 |
T |
A |
14: 47,783,081 (GRCm39) |
|
probably benign |
Het |
| Atm |
A |
T |
9: 53,408,562 (GRCm39) |
|
probably benign |
Het |
| Ccdc9 |
A |
G |
7: 16,018,434 (GRCm39) |
|
probably benign |
Het |
| Cers6 |
T |
C |
2: 68,899,013 (GRCm39) |
F217S |
probably benign |
Het |
| Crebbp |
A |
C |
16: 3,944,469 (GRCm39) |
|
probably null |
Het |
| Csmd1 |
T |
A |
8: 16,049,869 (GRCm39) |
|
probably benign |
Het |
| Dmac2l |
A |
T |
12: 69,787,819 (GRCm39) |
Y85F |
probably benign |
Het |
| Eml1 |
T |
A |
12: 108,496,571 (GRCm39) |
V609E |
probably damaging |
Het |
| Fryl |
A |
G |
5: 73,222,636 (GRCm39) |
S204P |
probably damaging |
Het |
| Gpr152 |
A |
G |
19: 4,192,843 (GRCm39) |
D128G |
probably damaging |
Het |
| Itgal |
T |
A |
7: 126,927,844 (GRCm39) |
V1013D |
possibly damaging |
Het |
| Kctd18 |
A |
G |
1: 58,004,559 (GRCm39) |
Y112H |
probably damaging |
Het |
| Kdm4d |
T |
A |
9: 14,375,850 (GRCm39) |
T3S |
probably benign |
Het |
| Lrp1b |
C |
T |
2: 41,000,765 (GRCm39) |
|
probably null |
Het |
| Mex3c |
T |
A |
18: 73,723,360 (GRCm39) |
D484E |
possibly damaging |
Het |
| Nalf1 |
T |
A |
8: 9,257,930 (GRCm39) |
D406V |
probably benign |
Het |
| Nat14 |
T |
C |
7: 4,927,050 (GRCm39) |
V74A |
possibly damaging |
Het |
| Or2b6 |
A |
G |
13: 21,823,510 (GRCm39) |
F61S |
probably damaging |
Het |
| Pabpc2 |
C |
T |
18: 39,908,193 (GRCm39) |
T486I |
probably benign |
Het |
| Pgm2 |
A |
G |
5: 64,260,289 (GRCm39) |
|
probably benign |
Het |
| Pkn3 |
T |
A |
2: 29,973,149 (GRCm39) |
I353N |
probably damaging |
Het |
| Rbm44 |
T |
A |
1: 91,083,260 (GRCm39) |
S594R |
possibly damaging |
Het |
| Rrbp1 |
C |
T |
2: 143,830,350 (GRCm39) |
A606T |
possibly damaging |
Het |
| Tcof1 |
A |
G |
18: 60,964,850 (GRCm39) |
V623A |
possibly damaging |
Het |
| Tg |
A |
G |
15: 66,577,123 (GRCm39) |
E1482G |
probably benign |
Het |
| Uba1 |
A |
G |
X: 20,541,885 (GRCm39) |
T546A |
probably benign |
Het |
| Zbtb38 |
A |
T |
9: 96,569,126 (GRCm39) |
W653R |
probably damaging |
Het |
| Zdhhc19 |
A |
T |
16: 32,318,440 (GRCm39) |
I99F |
probably damaging |
Het |
| Zfp236 |
T |
C |
18: 82,648,239 (GRCm39) |
Y974C |
probably damaging |
Het |
|
| Other mutations in Vmn2r37 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01346:Vmn2r37
|
APN |
7 |
9,209,680 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Vmn2r37
|
APN |
7 |
9,219,032 (GRCm39) |
nonsense |
probably null |
|
|
IGL02281:Vmn2r37
|
APN |
7 |
9,220,881 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02282:Vmn2r37
|
APN |
7 |
9,209,761 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0136:Vmn2r37
|
UTSW |
7 |
9,220,782 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Vmn2r37
|
UTSW |
7 |
9,220,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r37
|
UTSW |
7 |
9,220,943 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3158:Vmn2r37
|
UTSW |
7 |
9,220,713 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4084:Vmn2r37
|
UTSW |
7 |
9,218,984 (GRCm39) |
missense |
probably benign |
|
|
R4114:Vmn2r37
|
UTSW |
7 |
9,213,092 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5231:Vmn2r37
|
UTSW |
7 |
9,209,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5462:Vmn2r37
|
UTSW |
7 |
9,220,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r37
|
UTSW |
7 |
9,220,850 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7104:Vmn2r37
|
UTSW |
7 |
9,219,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7116:Vmn2r37
|
UTSW |
7 |
9,220,898 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7381:Vmn2r37
|
UTSW |
7 |
9,213,032 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8775:Vmn2r37
|
UTSW |
7 |
9,218,991 (GRCm39) |
nonsense |
probably null |
|
|
R8775-TAIL:Vmn2r37
|
UTSW |
7 |
9,218,991 (GRCm39) |
nonsense |
probably null |
|
|
R8869:Vmn2r37
|
UTSW |
7 |
9,209,854 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8884:Vmn2r37
|
UTSW |
7 |
9,218,916 (GRCm39) |
missense |
probably benign |
|
|
RF004:Vmn2r37
|
UTSW |
7 |
9,220,686 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Vmn2r37
|
UTSW |
7 |
9,212,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation