Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02514:Or13a21'

296664

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or13a21

Ensembl Gene

ENSMUSG00000063823

Gene Name

olfactory receptor family 13 subfamily A member 21

Synonyms

Olfr532, GA_x6K02T2PBJ9-42570051-42569122, MOR251-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02514

Quality Score

Status

Chromosome

Chromosomal Location

139998755-139999684 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 139999507 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 60 (Y60N)

Ref Sequence

ENSEMBL: ENSMUSP00000150798 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073226] [ENSMUST00000213801]

AlphaFold

Q8VGT4

Predicted Effect

probably damaging
Transcript: ENSMUST00000073226
AA Change: Y60N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000072959
Gene: ENSMUSG00000063823
AA Change: Y60N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	4.7e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.5e-6	PFAM
Pfam:7tm_1	41	290	1.7e-24	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213172

Predicted Effect

probably damaging
Transcript: ENSMUST00000213801
AA Change: Y60N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310009B15Rik	A	T	1: 138,779,909 (GRCm39)	C114*	probably null	Het
4933421I07Rik	A	G	7: 42,096,981 (GRCm39)	M110T	probably damaging	Het
Amer1	A	G	X: 94,470,117 (GRCm39)	V667A	possibly damaging	Het
Casr	C	T	16: 36,320,687 (GRCm39)	G487E	probably damaging	Het
Catsperd	G	A	17: 56,968,271 (GRCm39)	G552D	probably damaging	Het
Ceacam3	A	G	7: 16,896,906 (GRCm39)	D624G	possibly damaging	Het
Celsr2	A	G	3: 108,304,826 (GRCm39)	V2208A	probably benign	Het
Cibar1	T	G	4: 12,164,080 (GRCm39)		probably benign	Het
Clca4a	G	A	3: 144,660,832 (GRCm39)	S664F	probably damaging	Het
Ddx23	A	T	15: 98,556,199 (GRCm39)	S40T	unknown	Het
Dhodh	G	A	8: 110,332,896 (GRCm39)	R58*	probably null	Het
Dhx36	A	G	3: 62,408,319 (GRCm39)	L173S	possibly damaging	Het
Dnaaf5	C	T	5: 139,159,872 (GRCm39)		probably benign	Het
Dnah3	T	C	7: 119,565,470 (GRCm39)	D2546G	probably damaging	Het
Eef2	T	G	10: 81,015,427 (GRCm39)	I316S	probably benign	Het
Efcab6	T	C	15: 83,917,143 (GRCm39)	D139G	possibly damaging	Het
Efcab6	A	T	15: 83,755,512 (GRCm39)		probably benign	Het
Eif4g3	T	A	4: 137,853,505 (GRCm39)	I357N	possibly damaging	Het
Elovl2	G	A	13: 41,348,247 (GRCm39)	T44M	probably benign	Het
Fbln1	T	A	15: 85,128,463 (GRCm39)	C553*	probably null	Het
Fip1l1	T	C	5: 74,731,813 (GRCm39)	V310A	probably damaging	Het
Gast	A	G	11: 100,227,718 (GRCm39)	D100G	probably benign	Het
Gk	G	A	X: 84,756,970 (GRCm39)		probably benign	Het
Gm1330	G	A	2: 148,841,305 (GRCm39)		probably benign	Het
Hspg2	C	A	4: 137,296,887 (GRCm39)	T4355K	probably benign	Het
Ipo7	T	C	7: 109,648,035 (GRCm39)	V639A	possibly damaging	Het
Lrrc7	T	C	3: 157,865,929 (GRCm39)	M1271V	probably damaging	Het
Msantd1	T	A	5: 35,078,887 (GRCm39)	S141T	probably damaging	Het
Myo9b	T	C	8: 71,743,650 (GRCm39)	I237T	probably damaging	Het
Or10ag59	G	A	2: 87,405,537 (GRCm39)	M36I	probably benign	Het
Or2w3	T	C	11: 58,556,469 (GRCm39)	F28S	probably damaging	Het
Or4k40	A	C	2: 111,251,117 (GRCm39)	Y60D	probably damaging	Het
Pan2	A	T	10: 128,146,610 (GRCm39)	M416L	possibly damaging	Het
Pank4	T	C	4: 155,054,922 (GRCm39)	F209L	probably damaging	Het
Pcdhb13	A	T	18: 37,576,044 (GRCm39)	I141L	possibly damaging	Het
Pik3r2	A	G	8: 71,223,236 (GRCm39)	Y422H	probably benign	Het
Pramel14	T	C	4: 143,719,772 (GRCm39)	K198E	probably benign	Het
Prdm4	A	T	10: 85,743,781 (GRCm39)	I158N	probably damaging	Het
Prl	T	G	13: 27,243,377 (GRCm39)	L14R	probably damaging	Het
Rabl6	C	A	2: 25,498,188 (GRCm39)	A23S	probably damaging	Het
Rbm15b	T	A	9: 106,762,176 (GRCm39)	H664L	probably damaging	Het
Rhobtb1	T	A	10: 69,125,471 (GRCm39)	H618Q	probably benign	Het
Slc15a1	T	C	14: 121,724,452 (GRCm39)	K140R	probably damaging	Het
Slc6a17	A	G	3: 107,402,993 (GRCm39)	S145P	possibly damaging	Het
Snx31	T	C	15: 36,525,728 (GRCm39)	T324A	probably damaging	Het
Spatc1l	T	C	10: 76,405,490 (GRCm39)		probably benign	Het
Taar7b	A	G	10: 23,876,882 (GRCm39)	N349S	probably benign	Het
Tbx19	T	C	1: 164,981,273 (GRCm39)	I74V	probably benign	Het
Tmtc2	G	A	10: 105,025,960 (GRCm39)	T836I	possibly damaging	Het
Vmn2r72	C	A	7: 85,387,907 (GRCm39)	M552I	possibly damaging	Het
Vsig10l	A	G	7: 43,113,338 (GRCm39)	T199A	probably benign	Het
Washc4	A	T	10: 83,405,947 (GRCm39)	E481V	probably damaging	Het
Zc3h15	T	A	2: 83,483,725 (GRCm39)	N33K	probably damaging	Het

Other mutations in Or13a21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01684:Or13a21	APN	7	139,998,828 (GRCm39)	missense	probably damaging	1.00
IGL01743:Or13a21	APN	7	139,999,581 (GRCm39)	missense	probably damaging	1.00
IGL01797:Or13a21	APN	7	139,998,931 (GRCm39)	missense	probably damaging	1.00
IGL02291:Or13a21	APN	7	139,999,200 (GRCm39)	missense	probably damaging	1.00
IGL02382:Or13a21	APN	7	139,999,516 (GRCm39)	missense	possibly damaging	0.72
IGL02600:Or13a21	APN	7	139,998,862 (GRCm39)	missense	probably benign
IGL02613:Or13a21	APN	7	139,999,383 (GRCm39)	missense	probably benign	0.04
R0358:Or13a21	UTSW	7	139,998,856 (GRCm39)	missense	probably damaging	0.98
R0827:Or13a21	UTSW	7	139,999,380 (GRCm39)	missense	probably damaging	0.99
R1464:Or13a21	UTSW	7	139,999,286 (GRCm39)	missense	probably benign	0.01
R1464:Or13a21	UTSW	7	139,999,286 (GRCm39)	missense	probably benign	0.01
R1539:Or13a21	UTSW	7	139,999,326 (GRCm39)	missense	probably benign	0.26
R1691:Or13a21	UTSW	7	139,998,855 (GRCm39)	missense	probably damaging	1.00
R2012:Or13a21	UTSW	7	139,999,024 (GRCm39)	missense	probably damaging	1.00
R2195:Or13a21	UTSW	7	139,999,138 (GRCm39)	missense	possibly damaging	0.49
R4519:Or13a21	UTSW	7	139,999,123 (GRCm39)	missense	probably damaging	1.00
R6368:Or13a21	UTSW	7	139,999,580 (GRCm39)	nonsense	probably null
R6656:Or13a21	UTSW	7	139,999,517 (GRCm39)	missense	probably damaging	0.99
R7467:Or13a21	UTSW	7	139,999,287 (GRCm39)	missense	probably benign
R7610:Or13a21	UTSW	7	139,999,466 (GRCm39)	nonsense	probably null
R7795:Or13a21	UTSW	7	139,999,027 (GRCm39)	missense	possibly damaging	0.49
R7837:Or13a21	UTSW	7	139,999,234 (GRCm39)	missense	probably benign	0.01
R8755:Or13a21	UTSW	7	139,999,417 (GRCm39)	missense	probably benign	0.00
R9706:Or13a21	UTSW	7	139,999,266 (GRCm39)	missense	probably damaging	0.96

Posted On

2015-04-16