Incidental Mutation 'R0350:Rubcnl'
ID 29668
Institutional Source Beutler Lab
Gene Symbol Rubcnl
Ensembl Gene ENSMUSG00000034959
Gene Name RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms 5031414D18Rik, LOC380917
MMRRC Submission 038557-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R0350 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 75253467-75289972 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 75278331 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 372 (V372F)
Ref Sequence ENSEMBL: ENSMUSP00000045566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036072]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000036072
AA Change: V372F

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000045566
Gene: ENSMUSG00000034959
AA Change: V372F

DomainStartEndE-ValueType
DUF4206 463 664 1.01e-108 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228689
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 89.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd13 T A 8: 10,037,600 (GRCm39) Y66N probably damaging Het
Apol6 C T 15: 76,935,147 (GRCm39) Q139* probably null Het
Armh1 C A 4: 117,072,753 (GRCm39) E244* probably null Het
Cd1d1 A T 3: 86,904,880 (GRCm39) H219Q probably benign Het
Cdca2 A G 14: 67,950,568 (GRCm39) L121P probably benign Het
Cdin1 T C 2: 115,607,411 (GRCm39) Y255H possibly damaging Het
Cog4 T A 8: 111,580,328 (GRCm39) L133I possibly damaging Het
Csf1 T C 3: 107,655,922 (GRCm39) M370V probably benign Het
Ddi2 G A 4: 141,412,834 (GRCm39) T26M probably benign Het
Dhcr7 A G 7: 143,391,507 (GRCm39) D32G probably damaging Het
Efcab3 T C 11: 104,581,706 (GRCm39) V16A probably benign Het
Exd1 T C 2: 119,354,047 (GRCm39) N337S possibly damaging Het
Flii T C 11: 60,612,683 (GRCm39) D227G probably damaging Het
Hsf1 A G 15: 76,384,679 (GRCm39) T485A probably benign Het
Igfn1 G A 1: 135,884,505 (GRCm39) R2614* probably null Het
Iqch T C 9: 63,408,158 (GRCm39) T630A probably benign Het
Itgal T A 7: 126,921,253 (GRCm39) D770E probably damaging Het
Mroh1 T A 15: 76,316,449 (GRCm39) V759E probably damaging Het
Mrps17 A G 5: 129,795,209 (GRCm39) probably benign Het
Mtpap A G 18: 4,396,195 (GRCm39) S496G possibly damaging Het
Nkd1 T A 8: 89,311,844 (GRCm39) Y39* probably null Het
Nmd3 A G 3: 69,650,907 (GRCm39) Y359C probably damaging Het
Nr1h3 G A 2: 91,022,170 (GRCm39) L153F possibly damaging Het
Nuf2 T A 1: 169,341,112 (GRCm39) probably null Het
Or4b1b T C 2: 90,112,926 (GRCm39) probably null Het
Or4c113 T A 2: 88,885,700 (GRCm39) K23N probably benign Het
Or8b12i A T 9: 20,082,032 (GRCm39) Y278* probably null Het
Pnn T C 12: 59,113,903 (GRCm39) probably null Het
Ppm1j A G 3: 104,690,687 (GRCm39) D230G probably benign Het
Ppp1r15a A T 7: 45,172,442 (GRCm39) L650Q probably damaging Het
Prss37 T C 6: 40,491,893 (GRCm39) E229G probably damaging Het
Rbm19 T C 5: 120,266,372 (GRCm39) V465A possibly damaging Het
Sema6a G T 18: 47,403,785 (GRCm39) D595E probably benign Het
Slc35c1 A G 2: 92,289,377 (GRCm39) F43S probably damaging Het
Slc39a5 C T 10: 128,232,619 (GRCm39) probably null Het
Slco4c1 A G 1: 96,756,574 (GRCm39) F583L probably benign Het
Sox9 A G 11: 112,675,702 (GRCm39) Y297C probably damaging Het
Taf1b A G 12: 24,564,884 (GRCm39) D167G possibly damaging Het
Trpm6 T C 19: 18,861,321 (GRCm39) probably null Het
Uba6 A C 5: 86,292,237 (GRCm39) V402G possibly damaging Het
Usp43 T C 11: 67,767,324 (GRCm39) Y682C probably damaging Het
Vmn1r195 A G 13: 22,463,403 (GRCm39) D291G probably damaging Het
Xpr1 A T 1: 155,206,214 (GRCm39) F156Y probably damaging Het
Yju2b C T 8: 84,987,277 (GRCm39) E99K probably damaging Het
Zfp318 T A 17: 46,724,124 (GRCm39) H2042Q probably benign Het
Zfp937 T A 2: 150,081,222 (GRCm39) D417E possibly damaging Het
Other mutations in Rubcnl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02571:Rubcnl APN 14 75,269,576 (GRCm39) missense possibly damaging 0.75
IGL02730:Rubcnl APN 14 75,287,588 (GRCm39) missense probably damaging 1.00
R0019:Rubcnl UTSW 14 75,285,703 (GRCm39) splice site probably benign
R0147:Rubcnl UTSW 14 75,279,898 (GRCm39) missense probably damaging 1.00
R0148:Rubcnl UTSW 14 75,279,898 (GRCm39) missense probably damaging 1.00
R0487:Rubcnl UTSW 14 75,273,521 (GRCm39) missense probably benign 0.18
R0558:Rubcnl UTSW 14 75,284,987 (GRCm39) missense probably damaging 1.00
R1537:Rubcnl UTSW 14 75,278,267 (GRCm39) missense possibly damaging 0.92
R1791:Rubcnl UTSW 14 75,284,989 (GRCm39) missense probably damaging 1.00
R1871:Rubcnl UTSW 14 75,279,849 (GRCm39) missense possibly damaging 0.58
R2227:Rubcnl UTSW 14 75,279,832 (GRCm39) missense probably benign 0.00
R2263:Rubcnl UTSW 14 75,278,260 (GRCm39) missense possibly damaging 0.93
R2910:Rubcnl UTSW 14 75,278,248 (GRCm39) missense probably benign 0.06
R2911:Rubcnl UTSW 14 75,278,248 (GRCm39) missense probably benign 0.06
R3826:Rubcnl UTSW 14 75,269,665 (GRCm39) missense possibly damaging 0.72
R3870:Rubcnl UTSW 14 75,278,356 (GRCm39) missense probably benign 0.00
R3871:Rubcnl UTSW 14 75,278,356 (GRCm39) missense probably benign 0.00
R4007:Rubcnl UTSW 14 75,287,143 (GRCm39) missense possibly damaging 0.93
R4161:Rubcnl UTSW 14 75,281,898 (GRCm39) missense possibly damaging 0.82
R5004:Rubcnl UTSW 14 75,269,617 (GRCm39) nonsense probably null
R5041:Rubcnl UTSW 14 75,287,572 (GRCm39) missense probably damaging 1.00
R5468:Rubcnl UTSW 14 75,269,471 (GRCm39) missense possibly damaging 0.49
R5495:Rubcnl UTSW 14 75,279,777 (GRCm39) missense possibly damaging 0.61
R5739:Rubcnl UTSW 14 75,278,381 (GRCm39) splice site probably null
R5910:Rubcnl UTSW 14 75,272,912 (GRCm39) missense probably benign 0.26
R5948:Rubcnl UTSW 14 75,285,056 (GRCm39) missense probably damaging 1.00
R6038:Rubcnl UTSW 14 75,269,410 (GRCm39) missense probably benign 0.00
R6038:Rubcnl UTSW 14 75,269,410 (GRCm39) missense probably benign 0.00
R6197:Rubcnl UTSW 14 75,269,369 (GRCm39) missense probably damaging 0.99
R6297:Rubcnl UTSW 14 75,287,584 (GRCm39) missense probably benign 0.06
R6372:Rubcnl UTSW 14 75,285,009 (GRCm39) missense probably damaging 0.99
R6376:Rubcnl UTSW 14 75,269,834 (GRCm39) missense probably benign 0.01
R6377:Rubcnl UTSW 14 75,287,635 (GRCm39) splice site probably null
R6724:Rubcnl UTSW 14 75,289,450 (GRCm39) missense probably benign 0.00
R6884:Rubcnl UTSW 14 75,272,910 (GRCm39) missense probably benign 0.23
R7183:Rubcnl UTSW 14 75,287,066 (GRCm39) missense probably damaging 0.97
R7186:Rubcnl UTSW 14 75,269,453 (GRCm39) missense possibly damaging 0.91
R7345:Rubcnl UTSW 14 75,279,793 (GRCm39) missense probably benign
R7423:Rubcnl UTSW 14 75,287,083 (GRCm39) missense probably benign 0.09
R7548:Rubcnl UTSW 14 75,279,792 (GRCm39) missense probably benign
R7606:Rubcnl UTSW 14 75,276,314 (GRCm39) missense probably benign 0.41
R7699:Rubcnl UTSW 14 75,269,404 (GRCm39) missense probably benign
R7781:Rubcnl UTSW 14 75,269,530 (GRCm39) missense probably damaging 1.00
R8406:Rubcnl UTSW 14 75,289,425 (GRCm39) missense probably damaging 1.00
R8832:Rubcnl UTSW 14 75,269,359 (GRCm39) missense
R9053:Rubcnl UTSW 14 75,269,717 (GRCm39) missense possibly damaging 0.78
R9763:Rubcnl UTSW 14 75,287,108 (GRCm39) nonsense probably null
RF011:Rubcnl UTSW 14 75,281,878 (GRCm39) missense probably damaging 0.99
Z1176:Rubcnl UTSW 14 75,273,637 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- CACATCAGATGCTCAGCTTTGCAAC -3'
(R):5'- ACCTCAGGATACTTGAGAGTACGGC -3'

Sequencing Primer
(F):5'- GTGCTTAGCCAGAGAGTTGTTC -3'
(R):5'- gcacaccacagcgagac -3'
Posted On 2013-04-24