Incidental Mutation 'IGL02522:Trim12a'
ID296928
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim12a
Ensembl Gene ENSMUSG00000066258
Gene Nametripartite motif-containing 12A
Synonyms2310043C01Rik, Trim12
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02522
Quality Score
Status
Chromosome7
Chromosomal Location104299894-104315466 bp(-) (GRCm38)
Type of Mutationsplice site (5 bp from exon)
DNA Base Change (assembly) C to T at 104300831 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102452 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070943] [ENSMUST00000106837] [ENSMUST00000106839]
Predicted Effect probably benign
Transcript: ENSMUST00000070943
SMART Domains Protein: ENSMUSP00000065008
Gene: ENSMUSG00000066258

DomainStartEndE-ValueType
RING 15 58 7.8e-7 SMART
BBOX 91 132 9.01e-12 SMART
low complexity region 196 209 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106837
SMART Domains Protein: ENSMUSP00000102450
Gene: ENSMUSG00000066258

DomainStartEndE-ValueType
RING 15 58 7.8e-7 SMART
BBOX 91 132 9.01e-12 SMART
coiled coil region 140 200 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106839
SMART Domains Protein: ENSMUSP00000102452
Gene: ENSMUSG00000066258

DomainStartEndE-ValueType
RING 15 58 7.8e-7 SMART
BBOX 91 132 9.01e-12 SMART
low complexity region 196 209 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142641
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik A G 10: 79,067,799 S228P probably benign Het
Apba1 T C 19: 23,912,445 probably benign Het
Arel1 T C 12: 84,927,910 D486G probably damaging Het
BC030867 T C 11: 102,257,920 S386P possibly damaging Het
Celf1 T C 2: 91,009,301 V357A possibly damaging Het
Chd6 T C 2: 160,965,796 S1833G probably benign Het
Ctsa T C 2: 164,839,141 probably benign Het
Dclk2 G A 3: 86,920,116 P19S probably benign Het
Dpp10 T C 1: 123,423,652 H308R probably benign Het
Dst A T 1: 34,250,700 probably benign Het
Enpp2 A T 15: 54,898,940 M201K probably damaging Het
Epha7 A T 4: 28,821,494 T220S possibly damaging Het
Grip1 A G 10: 119,931,249 D93G probably damaging Het
Hipk3 T C 2: 104,471,331 K172R probably damaging Het
Iqgap3 A G 3: 88,108,398 N29S possibly damaging Het
Lyst T C 13: 13,634,705 V320A possibly damaging Het
Magi1 T C 6: 93,678,636 D1127G possibly damaging Het
Pkhd1l1 A T 15: 44,555,902 D2921V possibly damaging Het
Pla2r1 T A 2: 60,428,669 Y1125F probably benign Het
Psg20 T A 7: 18,682,431 L253F probably benign Het
Rdx A G 9: 52,068,204 K209R possibly damaging Het
Rpsa A T 9: 120,131,055 Q228L possibly damaging Het
Slc10a5 T C 3: 10,335,121 I160V probably benign Het
Tec C T 5: 72,789,172 V71I probably benign Het
Tln1 T C 4: 43,540,612 E1463G probably benign Het
Vcan G T 13: 89,704,849 T664K probably benign Het
Other mutations in Trim12a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01412:Trim12a APN 7 104306995 missense probably benign 0.37
IGL01866:Trim12a APN 7 104304153 splice site probably benign
R0900:Trim12a UTSW 7 104304262 missense probably benign 0.00
R1673:Trim12a UTSW 7 104306057 missense possibly damaging 0.93
R1856:Trim12a UTSW 7 104300857 missense probably benign 0.20
R1928:Trim12a UTSW 7 104307124 missense probably damaging 1.00
R2187:Trim12a UTSW 7 104304192 missense probably damaging 0.98
R2391:Trim12a UTSW 7 104306931 missense probably damaging 0.99
R3124:Trim12a UTSW 7 104300856 missense probably benign 0.37
R3808:Trim12a UTSW 7 104306994 missense probably benign 0.05
R4409:Trim12a UTSW 7 104306994 missense probably benign 0.05
R4951:Trim12a UTSW 7 104304358 missense possibly damaging 0.90
R5325:Trim12a UTSW 7 104304206 missense probably damaging 1.00
R5694:Trim12a UTSW 7 104307243 missense probably damaging 1.00
R6376:Trim12a UTSW 7 104306034 missense probably benign 0.03
Posted On2015-04-16