Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02531:Vmn2r16'

297302

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r16

Ensembl Gene

ENSMUSG00000092080

Gene Name

vomeronasal 2, receptor 16

Synonyms

EG384220

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.170) question?

Stock #

IGL02531

Quality Score

Status

Chromosome

Chromosomal Location

109478247-109512347 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 109488134 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 336 (T336A)

Ref Sequence

ENSEMBL: ENSMUSP00000127838 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165180]

AlphaFold

A0A3B2WCY4

Predicted Effect

probably damaging
Transcript: ENSMUST00000165180
AA Change: T336A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: T336A

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	425	2.3e-28	PFAM
Pfam:NCD3G	509	563	8.2e-19	PFAM
Pfam:7tm_3	596	831	3.5e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	C	A	6: 86,933,429 (GRCm39)	H467N	unknown	Het
Alb	A	G	5: 90,615,307 (GRCm39)	D273G	probably damaging	Het
Arap3	A	G	18: 38,122,804 (GRCm39)	S531P	probably damaging	Het
Bmpr2	T	A	1: 59,884,873 (GRCm39)		probably null	Het
Cfhr4	T	C	1: 139,702,307 (GRCm39)	K59R	probably benign	Het
Chd7	G	A	4: 8,854,134 (GRCm39)	R1902H	probably damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyp2b13	A	T	7: 25,761,030 (GRCm39)	H29L	possibly damaging	Het
Enpp5	G	T	17: 44,391,843 (GRCm39)	V91F	probably damaging	Het
Fam210b	T	C	2: 172,194,675 (GRCm39)	Y176H	probably damaging	Het
Fam83b	T	C	9: 76,399,282 (GRCm39)	E607G	possibly damaging	Het
Hhla1	C	T	15: 65,839,256 (GRCm39)		probably benign	Het
Kdm3b	A	G	18: 34,928,782 (GRCm39)	T178A	probably benign	Het
Klf1	T	A	8: 85,631,437 (GRCm39)	F334I	probably damaging	Het
Klra8	A	G	6: 130,095,933 (GRCm39)	S220P	possibly damaging	Het
Medag	A	G	5: 149,345,616 (GRCm39)	N99S	probably benign	Het
Muc6	T	C	7: 141,216,853 (GRCm39)	T2607A	possibly damaging	Het
Mug2	T	G	6: 122,049,730 (GRCm39)	L921R	probably damaging	Het
Nacad	T	C	11: 6,548,580 (GRCm39)	N1385D	possibly damaging	Het
Nin	A	G	12: 70,067,706 (GRCm39)	F1983L	probably benign	Het
Nipal4	T	C	11: 46,042,152 (GRCm39)	I176M	probably damaging	Het
Orc6	T	C	8: 86,029,998 (GRCm39)	S47P	probably damaging	Het
Ovch2	C	T	7: 107,389,405 (GRCm39)	C341Y	probably damaging	Het
Polq	T	A	16: 36,882,736 (GRCm39)	H1633Q	possibly damaging	Het
Rab23	T	C	1: 33,777,361 (GRCm39)		probably benign	Het
Rai14	A	G	15: 10,574,868 (GRCm39)	S697P	probably damaging	Het
Rnf213	T	C	11: 119,327,628 (GRCm39)	F1872L	probably benign	Het
Sdhc	T	C	1: 170,963,587 (GRCm39)	H127R	probably damaging	Het
Snx9	T	C	17: 5,942,095 (GRCm39)	V74A	probably benign	Het
Spata31d1d	A	G	13: 59,875,748 (GRCm39)	S596P	possibly damaging	Het
Syt14	T	C	1: 192,584,242 (GRCm39)	*78W	probably null	Het
Thoc1	A	G	18: 9,970,258 (GRCm39)	T203A	probably benign	Het
Trmt13	A	G	3: 116,385,840 (GRCm39)		probably null	Het
Ttc28	A	G	5: 111,373,716 (GRCm39)	I1020V	probably damaging	Het

Other mutations in Vmn2r16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01116:Vmn2r16	APN	5	109,488,294 (GRCm39)	missense	probably damaging	1.00
IGL01374:Vmn2r16	APN	5	109,478,283 (GRCm39)	missense	probably benign	0.00
IGL01391:Vmn2r16	APN	5	109,511,627 (GRCm39)	missense	possibly damaging	0.50
IGL01419:Vmn2r16	APN	5	109,510,267 (GRCm39)	splice site	probably benign
IGL01634:Vmn2r16	APN	5	109,488,177 (GRCm39)	missense	probably benign	0.00
IGL01845:Vmn2r16	APN	5	109,511,762 (GRCm39)	missense	probably damaging	1.00
IGL01875:Vmn2r16	APN	5	109,478,277 (GRCm39)	missense	probably benign	0.01
IGL01910:Vmn2r16	APN	5	109,487,951 (GRCm39)	missense	probably damaging	1.00
IGL02217:Vmn2r16	APN	5	109,487,676 (GRCm39)	missense	probably damaging	0.98
IGL02327:Vmn2r16	APN	5	109,487,987 (GRCm39)	missense	probably benign	0.01
IGL02491:Vmn2r16	APN	5	109,487,703 (GRCm39)	nonsense	probably null
IGL02680:Vmn2r16	APN	5	109,487,948 (GRCm39)	missense	probably benign	0.44
IGL02884:Vmn2r16	APN	5	109,508,757 (GRCm39)	missense	possibly damaging	0.94
IGL03084:Vmn2r16	APN	5	109,478,292 (GRCm39)	missense	probably damaging	0.99
IGL03096:Vmn2r16	APN	5	109,487,751 (GRCm39)	missense	probably damaging	0.99
IGL03355:Vmn2r16	APN	5	109,511,580 (GRCm39)	missense	possibly damaging	0.74
R0280:Vmn2r16	UTSW	5	109,488,005 (GRCm39)	missense	possibly damaging	0.88
R0594:Vmn2r16	UTSW	5	109,511,762 (GRCm39)	missense	probably damaging	1.00
R1016:Vmn2r16	UTSW	5	109,487,754 (GRCm39)	missense	probably damaging	1.00
R1109:Vmn2r16	UTSW	5	109,487,652 (GRCm39)	missense	probably damaging	0.98
R1248:Vmn2r16	UTSW	5	109,508,643 (GRCm39)	missense	probably benign	0.10
R1626:Vmn2r16	UTSW	5	109,511,443 (GRCm39)	missense	probably damaging	1.00
R1909:Vmn2r16	UTSW	5	109,511,853 (GRCm39)	missense	probably benign	0.01
R1929:Vmn2r16	UTSW	5	109,487,124 (GRCm39)	missense	possibly damaging	0.92
R1982:Vmn2r16	UTSW	5	109,511,890 (GRCm39)	missense	probably benign	0.01
R3038:Vmn2r16	UTSW	5	109,487,199 (GRCm39)	missense	probably damaging	1.00
R3437:Vmn2r16	UTSW	5	109,478,362 (GRCm39)	missense	probably damaging	0.99
R3734:Vmn2r16	UTSW	5	109,478,280 (GRCm39)	missense	probably benign	0.11
R3820:Vmn2r16	UTSW	5	109,510,143 (GRCm39)	missense	probably benign	0.36
R3873:Vmn2r16	UTSW	5	109,488,177 (GRCm39)	missense	probably benign	0.33
R4165:Vmn2r16	UTSW	5	109,478,427 (GRCm39)	missense	possibly damaging	0.80
R4373:Vmn2r16	UTSW	5	109,511,667 (GRCm39)	missense	probably damaging	1.00
R4575:Vmn2r16	UTSW	5	109,511,665 (GRCm39)	missense	possibly damaging	0.81
R4576:Vmn2r16	UTSW	5	109,511,665 (GRCm39)	missense	possibly damaging	0.81
R4578:Vmn2r16	UTSW	5	109,511,665 (GRCm39)	missense	possibly damaging	0.81
R4637:Vmn2r16	UTSW	5	109,478,280 (GRCm39)	missense	probably benign	0.00
R4696:Vmn2r16	UTSW	5	109,487,168 (GRCm39)	missense	probably benign	0.01
R5026:Vmn2r16	UTSW	5	109,508,722 (GRCm39)	nonsense	probably null
R5180:Vmn2r16	UTSW	5	109,478,391 (GRCm39)	missense	probably benign	0.01
R5433:Vmn2r16	UTSW	5	109,511,708 (GRCm39)	missense	probably damaging	1.00
R5955:Vmn2r16	UTSW	5	109,511,613 (GRCm39)	missense	possibly damaging	0.78
R5958:Vmn2r16	UTSW	5	109,510,153 (GRCm39)	missense	possibly damaging	0.81
R6353:Vmn2r16	UTSW	5	109,488,119 (GRCm39)	missense	probably benign	0.33
R6389:Vmn2r16	UTSW	5	109,478,344 (GRCm39)	missense	probably benign	0.19
R6819:Vmn2r16	UTSW	5	109,488,412 (GRCm39)	missense	probably benign	0.04
R6994:Vmn2r16	UTSW	5	109,487,969 (GRCm39)	missense	probably damaging	1.00
R7061:Vmn2r16	UTSW	5	109,511,620 (GRCm39)	missense	probably damaging	0.99
R7063:Vmn2r16	UTSW	5	109,511,650 (GRCm39)	missense	probably damaging	1.00
R7220:Vmn2r16	UTSW	5	109,508,772 (GRCm39)	missense	probably damaging	0.97
R7268:Vmn2r16	UTSW	5	109,488,331 (GRCm39)	nonsense	probably null
R7420:Vmn2r16	UTSW	5	109,511,736 (GRCm39)	missense	probably damaging	0.96
R7591:Vmn2r16	UTSW	5	109,510,223 (GRCm39)	missense	probably damaging	0.99
R7644:Vmn2r16	UTSW	5	109,487,837 (GRCm39)	missense	probably damaging	1.00
R7939:Vmn2r16	UTSW	5	109,487,705 (GRCm39)	missense	possibly damaging	0.79
R7977:Vmn2r16	UTSW	5	109,488,015 (GRCm39)	missense	probably damaging	1.00
R7987:Vmn2r16	UTSW	5	109,488,015 (GRCm39)	missense	probably damaging	1.00
R8023:Vmn2r16	UTSW	5	109,488,272 (GRCm39)	nonsense	probably null
R8427:Vmn2r16	UTSW	5	109,488,138 (GRCm39)	missense	probably benign	0.03
R8436:Vmn2r16	UTSW	5	109,511,649 (GRCm39)	missense	probably damaging	1.00
R8475:Vmn2r16	UTSW	5	109,487,073 (GRCm39)	missense	probably benign	0.01
R8554:Vmn2r16	UTSW	5	109,511,997 (GRCm39)	missense	probably benign	0.13
R8771:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8774:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8774-TAIL:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8775:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8775-TAIL:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8777:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8777-TAIL:Vmn2r16	UTSW	5	109,488,231 (GRCm39)	missense	probably benign	0.00
R8825:Vmn2r16	UTSW	5	109,487,019 (GRCm39)	missense	probably benign	0.41
R8865:Vmn2r16	UTSW	5	109,487,910 (GRCm39)	missense	probably benign	0.33
R8900:Vmn2r16	UTSW	5	109,511,619 (GRCm39)	missense	probably benign	0.04
R9365:Vmn2r16	UTSW	5	109,488,064 (GRCm39)	missense	probably damaging	0.99
R9683:Vmn2r16	UTSW	5	109,511,677 (GRCm39)	missense	probably damaging	1.00
X0027:Vmn2r16	UTSW	5	109,487,175 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r16	UTSW	5	109,511,779 (GRCm39)	frame shift	probably null
Z1088:Vmn2r16	UTSW	5	109,488,381 (GRCm39)	missense	probably benign	0.03
Z1177:Vmn2r16	UTSW	5	109,487,864 (GRCm39)	missense	possibly damaging	0.79

Posted On

2015-04-16