Incidental Mutation 'IGL02536:Prdx4'
ID 297518
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prdx4
Ensembl Gene ENSMUSG00000025289
Gene Name peroxiredoxin 4
Synonyms Prx4, Prx IV, AOE372, Prx-iv
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL02536
Quality Score
Status
Chromosome X
Chromosomal Location 154106914-154123750 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 154115443 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 132 (I132F)
Ref Sequence ENSEMBL: ENSMUSP00000026328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026328] [ENSMUST00000130349]
AlphaFold O08807
PDB Structure Crystal structure of peroxiredoxin 4 from M. musculus [X-RAY DIFFRACTION]
crystal structure of N-terminally truncated peroxiredoxin 4 from M. musculus [X-RAY DIFFRACTION]
Crystal structure of P5 a0 in a complex with Prx4 c-term [X-RAY DIFFRACTION]
Crystal structure of ERp46 Trx2 in a complex with Prx4 C-term [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000026328
AA Change: I132F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000026328
Gene: ENSMUSG00000025289
AA Change: I132F

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:AhpC-TSA 84 217 4.3e-36 PFAM
Pfam:Redoxin 84 232 4.4e-15 PFAM
Pfam:1-cysPrx_C 237 272 9.6e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123915
Predicted Effect possibly damaging
Transcript: ENSMUST00000130349
AA Change: I115F

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000122997
Gene: ENSMUSG00000025289
AA Change: I115F

DomainStartEndE-ValueType
low complexity region 32 47 N/A INTRINSIC
Pfam:AhpC-TSA 67 200 2.9e-37 PFAM
Pfam:Redoxin 68 217 9.6e-16 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930449A18Rik T A 3: 59,685,665 (GRCm39) noncoding transcript Het
Abca8b C T 11: 109,872,574 (GRCm39) R9H probably benign Het
Adamts8 T A 9: 30,873,368 (GRCm39) S858T probably benign Het
Alg1 C T 16: 5,057,023 (GRCm39) Q245* probably null Het
Ankmy1 T C 1: 92,813,910 (GRCm39) Y423C probably damaging Het
Anp32a A T 9: 62,279,110 (GRCm39) T55S probably damaging Het
Arhgef9 A C X: 94,102,443 (GRCm39) V406G probably damaging Het
Bdkrb1 T C 12: 105,571,259 (GRCm39) F275S possibly damaging Het
Card9 C T 2: 26,248,844 (GRCm39) V102I possibly damaging Het
Ccdc81 A T 7: 89,526,788 (GRCm39) probably benign Het
Cd101 T A 3: 100,910,913 (GRCm39) D915V probably damaging Het
Cdk10 A G 8: 123,953,754 (GRCm39) D77G possibly damaging Het
Ctnnd1 T C 2: 84,435,540 (GRCm39) T827A probably benign Het
Dspp A C 5: 104,323,531 (GRCm39) T225P probably damaging Het
Evpl T C 11: 116,112,035 (GRCm39) E1885G probably damaging Het
Fstl4 C T 11: 53,024,851 (GRCm39) probably benign Het
Gm5930 T A 14: 44,575,015 (GRCm39) N57I probably damaging Het
Gnl2 C T 4: 124,946,401 (GRCm39) Q541* probably null Het
Igkv3-1 T C 6: 70,681,035 (GRCm39) V78A probably benign Het
Inpp5a T C 7: 139,147,338 (GRCm39) I321T probably benign Het
Kif20b T A 19: 34,951,959 (GRCm39) S1746T probably benign Het
Lrrc8c T C 5: 105,755,038 (GRCm39) I271T probably benign Het
Mrps10 T C 17: 47,685,928 (GRCm39) Y152H probably damaging Het
Myl9 C T 2: 156,620,469 (GRCm39) S2L probably damaging Het
Myof A T 19: 37,938,103 (GRCm39) H870Q probably damaging Het
Nfatc4 A T 14: 56,067,367 (GRCm39) I456F probably damaging Het
Notch2 A G 3: 98,009,723 (GRCm39) H550R probably benign Het
Or13f5 T A 4: 52,825,817 (GRCm39) V140D possibly damaging Het
Or14j2 T A 17: 37,885,817 (GRCm39) I166F probably damaging Het
Or51v8 T A 7: 103,320,164 (GRCm39) I25F possibly damaging Het
Or8b47 T C 9: 38,435,460 (GRCm39) L144P probably damaging Het
P2rx1 A T 11: 72,903,300 (GRCm39) I230F probably damaging Het
Pcnt A G 10: 76,216,063 (GRCm39) V2275A possibly damaging Het
Pip5k1a G A 3: 94,971,707 (GRCm39) T465I probably benign Het
Pnkd G A 1: 74,391,059 (GRCm39) R415H probably damaging Het
Pvr A G 7: 19,652,717 (GRCm39) M66T probably benign Het
Rnf216 A G 5: 143,065,995 (GRCm39) I531T probably benign Het
Rps6ka4 A T 19: 6,809,439 (GRCm39) F405Y probably damaging Het
Serpinb2 A G 1: 107,452,679 (GRCm39) probably benign Het
Sfxn1 A G 13: 54,239,513 (GRCm39) K12R probably benign Het
Slc17a7 A G 7: 44,820,370 (GRCm39) E275G probably damaging Het
Tnpo2 A T 8: 85,771,696 (GRCm39) I245F probably benign Het
Ush2a A T 1: 188,689,463 (GRCm39) probably null Het
Yju2b A T 8: 84,987,245 (GRCm39) Y109* probably null Het
Zcchc4 C T 5: 52,965,658 (GRCm39) R321W probably damaging Het
Other mutations in Prdx4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2869:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2869:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2871:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2871:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2872:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2872:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2874:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R3115:Prdx4 UTSW X 154,113,407 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16