Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02539:Tmem132d'

297635

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132d

Ensembl Gene

ENSMUSG00000034310

Gene Name

transmembrane protein 132D

Synonyms

C630028F04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.133) question?

Stock #

IGL02539

Quality Score

Status

Chromosome

Chromosomal Location

127860555-128510141 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 127861043 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 1026 (Q1026L)

Ref Sequence

ENSEMBL: ENSMUSP00000043633 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044441]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000044441
AA Change: Q1026L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000043633
Gene: ENSMUSG00000034310
AA Change: Q1026L

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
Pfam:TMEM132D_N	49	178	1.9e-59	PFAM
Pfam:TMEM132	435	778	3.9e-150	PFAM
Pfam:TMEM132D_C	884	970	1.9e-37	PFAM
low complexity region	998	1011	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	A	T	8: 25,276,229 (GRCm39)	Y479*	probably null	Het
Btnl6	T	C	17: 34,727,288 (GRCm39)	N414S	probably benign	Het
Ccdc180	A	G	4: 45,921,005 (GRCm39)	N984D	probably damaging	Het
Cfc1	A	T	1: 34,576,203 (GRCm39)		probably benign	Het
Chrm1	G	A	19: 8,655,675 (GRCm39)	V127M	probably damaging	Het
Dicer1	A	G	12: 104,663,294 (GRCm39)	L1429P	probably damaging	Het
Erbb3	A	G	10: 128,420,174 (GRCm39)		probably null	Het
Evi5	T	C	5: 107,963,531 (GRCm39)	E348G	probably benign	Het
Fat2	G	A	11: 55,172,619 (GRCm39)	T2698I	probably damaging	Het
Gas2	A	G	7: 51,547,038 (GRCm39)	D63G	possibly damaging	Het
Gm28042	A	G	2: 119,865,702 (GRCm39)	D313G	probably damaging	Het
Hivep2	T	A	10: 14,007,622 (GRCm39)	S1407T	probably damaging	Het
Ibsp	T	A	5: 104,450,149 (GRCm39)	M19K	probably damaging	Het
Itih3	C	T	14: 30,634,621 (GRCm39)	D129N	probably benign	Het
Krtap4-8	A	T	11: 99,671,196 (GRCm39)		probably benign	Het
Mertk	A	G	2: 128,643,210 (GRCm39)	T870A	probably damaging	Het
Mtmr11	C	A	3: 96,072,308 (GRCm39)		probably benign	Het
Nbas	C	A	12: 13,322,704 (GRCm39)		probably benign	Het
Nlrp4b	A	G	7: 10,448,355 (GRCm39)	D186G	probably damaging	Het
Olfm3	A	G	3: 114,895,579 (GRCm39)	I154V	possibly damaging	Het
Or10a5	T	A	7: 106,635,641 (GRCm39)	I93N	probably damaging	Het
Pdk2	T	C	11: 94,923,321 (GRCm39)	K101R	probably benign	Het
Pds5a	C	T	5: 65,823,462 (GRCm39)	D110N	probably damaging	Het
Pex5	A	T	6: 124,380,183 (GRCm39)	D288E	probably benign	Het
Pitrm1	A	G	13: 6,618,792 (GRCm39)	D655G	probably benign	Het
Plcz1	T	C	6: 139,938,690 (GRCm39)	N554S	probably benign	Het
Plin4	T	C	17: 56,413,680 (GRCm39)	Q315R	probably damaging	Het
Plpp5	A	G	8: 26,214,215 (GRCm39)	H244R	probably benign	Het
Ppp1r3a	C	T	6: 14,718,458 (GRCm39)	V819I	probably benign	Het
Rap1b	T	A	10: 117,658,709 (GRCm39)	R41S	possibly damaging	Het
Rc3h2	T	A	2: 37,279,727 (GRCm39)	S501C	probably benign	Het
Sel1l2	G	T	2: 140,072,778 (GRCm39)	A619D	probably damaging	Het
Ska3	T	C	14: 58,057,968 (GRCm39)	D128G	possibly damaging	Het
Specc1l	A	T	10: 75,103,342 (GRCm39)	I889L	probably benign	Het
Ssxb5	T	A	X: 8,675,087 (GRCm39)	N130K	probably damaging	Het
Tanc1	G	T	2: 59,663,602 (GRCm39)	G1120C	probably damaging	Het
Tet1	T	C	10: 62,648,798 (GRCm39)	Q267R	possibly damaging	Het
Tlr8	T	A	X: 166,027,152 (GRCm39)	H566L	possibly damaging	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Trp53bp2	C	A	1: 182,276,256 (GRCm39)	P746T	probably damaging	Het
Uso1	A	T	5: 92,335,632 (GRCm39)	I547F	probably damaging	Het
Zfp687	A	C	3: 94,918,373 (GRCm39)	N466K	probably damaging	Het

Other mutations in Tmem132d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Tmem132d	APN	5	127,861,896 (GRCm39)	missense	possibly damaging	0.77
IGL01393:Tmem132d	APN	5	127,861,702 (GRCm39)	missense	probably benign	0.31
IGL01482:Tmem132d	APN	5	128,346,270 (GRCm39)	missense	probably damaging	0.96
IGL01785:Tmem132d	APN	5	128,061,379 (GRCm39)	missense	probably benign	0.00
IGL02409:Tmem132d	APN	5	127,861,952 (GRCm39)	missense	probably damaging	1.00
IGL03411:Tmem132d	APN	5	128,061,347 (GRCm39)	nonsense	probably null
R0113:Tmem132d	UTSW	5	127,861,657 (GRCm39)	missense	probably benign	0.11
R0420:Tmem132d	UTSW	5	127,941,710 (GRCm39)	missense	probably benign	0.26
R0437:Tmem132d	UTSW	5	127,866,849 (GRCm39)	missense	probably damaging	0.99
R0468:Tmem132d	UTSW	5	128,346,267 (GRCm39)	missense	probably damaging	1.00
R0564:Tmem132d	UTSW	5	127,861,842 (GRCm39)	missense	probably damaging	1.00
R0659:Tmem132d	UTSW	5	128,061,351 (GRCm39)	missense	possibly damaging	0.94
R0924:Tmem132d	UTSW	5	128,061,503 (GRCm39)	splice site	probably benign
R1209:Tmem132d	UTSW	5	127,861,934 (GRCm39)	missense	probably damaging	1.00
R1333:Tmem132d	UTSW	5	127,861,923 (GRCm39)	missense	probably benign
R1378:Tmem132d	UTSW	5	128,346,011 (GRCm39)	missense	probably benign	0.43
R1741:Tmem132d	UTSW	5	127,861,922 (GRCm39)	missense	probably benign	0.30
R1753:Tmem132d	UTSW	5	127,866,919 (GRCm39)	missense	probably benign	0.02
R1944:Tmem132d	UTSW	5	127,860,828 (GRCm39)	makesense	probably null
R1974:Tmem132d	UTSW	5	128,346,263 (GRCm39)	missense	probably damaging	0.99
R2035:Tmem132d	UTSW	5	127,869,522 (GRCm39)	missense	probably damaging	1.00
R2065:Tmem132d	UTSW	5	127,861,505 (GRCm39)	missense	probably benign
R2074:Tmem132d	UTSW	5	128,346,195 (GRCm39)	missense	probably damaging	1.00
R2276:Tmem132d	UTSW	5	127,872,987 (GRCm39)	missense	probably damaging	1.00
R2297:Tmem132d	UTSW	5	128,345,608 (GRCm39)	missense	possibly damaging	0.69
R2424:Tmem132d	UTSW	5	127,941,663 (GRCm39)	missense	probably benign	0.09
R2902:Tmem132d	UTSW	5	127,860,832 (GRCm39)	missense	probably benign
R3053:Tmem132d	UTSW	5	127,869,538 (GRCm39)	missense	probably benign	0.15
R3836:Tmem132d	UTSW	5	127,861,949 (GRCm39)	missense	probably damaging	1.00
R4127:Tmem132d	UTSW	5	128,345,884 (GRCm39)	missense	probably benign	0.35
R4236:Tmem132d	UTSW	5	128,509,389 (GRCm39)	missense	possibly damaging	0.89
R4358:Tmem132d	UTSW	5	128,061,405 (GRCm39)	missense	possibly damaging	0.92
R4610:Tmem132d	UTSW	5	128,061,360 (GRCm39)	missense	probably benign	0.29
R4686:Tmem132d	UTSW	5	127,869,674 (GRCm39)	missense	possibly damaging	0.55
R4814:Tmem132d	UTSW	5	128,061,328 (GRCm39)	missense	probably benign	0.01
R4883:Tmem132d	UTSW	5	128,346,366 (GRCm39)	missense	possibly damaging	0.79
R4883:Tmem132d	UTSW	5	128,346,364 (GRCm39)	missense	probably damaging	0.99
R4939:Tmem132d	UTSW	5	127,873,139 (GRCm39)	missense	probably damaging	1.00
R5579:Tmem132d	UTSW	5	127,873,064 (GRCm39)	missense	possibly damaging	0.67
R5652:Tmem132d	UTSW	5	127,861,859 (GRCm39)	missense	possibly damaging	0.88
R5801:Tmem132d	UTSW	5	127,861,964 (GRCm39)	missense	possibly damaging	0.50
R5900:Tmem132d	UTSW	5	128,346,336 (GRCm39)	missense	probably damaging	1.00
R5980:Tmem132d	UTSW	5	127,861,662 (GRCm39)	missense	probably benign	0.13
R6048:Tmem132d	UTSW	5	128,346,181 (GRCm39)	missense	probably benign	0.03
R6057:Tmem132d	UTSW	5	127,861,934 (GRCm39)	missense	probably damaging	1.00
R6084:Tmem132d	UTSW	5	127,861,164 (GRCm39)	missense	probably benign	0.06
R6505:Tmem132d	UTSW	5	127,861,502 (GRCm39)	missense	probably benign	0.00
R6522:Tmem132d	UTSW	5	127,860,832 (GRCm39)	missense	probably benign
R6540:Tmem132d	UTSW	5	128,345,596 (GRCm39)	missense	possibly damaging	0.87
R6717:Tmem132d	UTSW	5	127,861,485 (GRCm39)	missense	probably benign
R7158:Tmem132d	UTSW	5	128,214,083 (GRCm39)	missense	possibly damaging	0.81
R7287:Tmem132d	UTSW	5	128,061,415 (GRCm39)	missense	probably damaging	0.96
R7526:Tmem132d	UTSW	5	127,861,205 (GRCm39)	nonsense	probably null
R7826:Tmem132d	UTSW	5	127,866,953 (GRCm39)	missense	probably damaging	1.00
R7864:Tmem132d	UTSW	5	127,860,980 (GRCm39)	missense	probably damaging	1.00
R8124:Tmem132d	UTSW	5	127,869,624 (GRCm39)	missense	probably damaging	1.00
R8543:Tmem132d	UTSW	5	128,345,799 (GRCm39)	missense	probably benign	0.00
R8694:Tmem132d	UTSW	5	127,869,495 (GRCm39)	missense	probably benign	0.06
R8936:Tmem132d	UTSW	5	127,869,676 (GRCm39)	missense	probably damaging	1.00
R9017:Tmem132d	UTSW	5	128,346,316 (GRCm39)	missense	probably benign	0.00
R9017:Tmem132d	UTSW	5	127,866,936 (GRCm39)	missense	probably benign	0.00
R9163:Tmem132d	UTSW	5	127,869,570 (GRCm39)	missense	possibly damaging	0.82
R9257:Tmem132d	UTSW	5	127,861,491 (GRCm39)	nonsense	probably null
R9645:Tmem132d	UTSW	5	128,346,075 (GRCm39)	missense	probably damaging	1.00
R9667:Tmem132d	UTSW	5	128,061,375 (GRCm39)	missense	possibly damaging	0.79
R9711:Tmem132d	UTSW	5	127,869,579 (GRCm39)	missense	possibly damaging	0.94

Posted On

2015-04-16