Incidental Mutation 'IGL02552:Tesmin'
ID 298171
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tesmin
Ensembl Gene ENSMUSG00000024905
Gene Name testis expressed metallothionein like
Synonyms Mtl5, tesmin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # IGL02552
Quality Score
Status
Chromosome 19
Chromosomal Location 3438857-3457823 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 3452483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114142 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025840] [ENSMUST00000127142] [ENSMUST00000142193] [ENSMUST00000151341]
AlphaFold Q9WTJ6
Predicted Effect probably benign
Transcript: ENSMUST00000025840
SMART Domains Protein: ENSMUSP00000025840
Gene: ENSMUSG00000024905

DomainStartEndE-ValueType
low complexity region 91 99 N/A INTRINSIC
low complexity region 107 123 N/A INTRINSIC
Blast:CXC 246 287 4e-13 BLAST
CXC 332 373 1.37e-17 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127142
SMART Domains Protein: ENSMUSP00000122687
Gene: ENSMUSG00000024905

DomainStartEndE-ValueType
Blast:CXC 67 107 1e-13 BLAST
CXC 152 193 1.37e-17 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000142193
SMART Domains Protein: ENSMUSP00000114171
Gene: ENSMUSG00000024905

DomainStartEndE-ValueType
Blast:CXC 67 107 1e-13 BLAST
CXC 152 193 1.37e-17 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151341
SMART Domains Protein: ENSMUSP00000114142
Gene: ENSMUSG00000024905

DomainStartEndE-ValueType
low complexity region 91 99 N/A INTRINSIC
low complexity region 107 123 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A G 3: 124,208,145 (GRCm39) L178S probably damaging Het
Abca12 A G 1: 71,333,906 (GRCm39) Y1199H probably damaging Het
Abcc9 T C 6: 142,551,645 (GRCm39) D1221G possibly damaging Het
Apc T A 18: 34,446,035 (GRCm39) M977K possibly damaging Het
Arhgap30 T A 1: 171,235,324 (GRCm39) L566Q probably damaging Het
Arhgap40 T A 2: 158,388,721 (GRCm39) W552R probably benign Het
Astn1 C T 1: 158,332,965 (GRCm39) S349F possibly damaging Het
Bard1 T C 1: 71,104,815 (GRCm39) probably benign Het
Batf2 T A 19: 6,221,537 (GRCm39) Y116N probably benign Het
Bltp3b T A 10: 89,642,605 (GRCm39) L10* probably null Het
Cbx6 T C 15: 79,713,094 (GRCm39) H111R probably damaging Het
Cd44 T A 2: 102,679,076 (GRCm39) N242I probably benign Het
Cdnf C T 2: 3,525,012 (GRCm39) Q184* probably null Het
Chd2 C A 7: 73,097,068 (GRCm39) probably benign Het
Cmtm6 G A 9: 114,566,374 (GRCm39) V88M probably damaging Het
Col24a1 C A 3: 145,179,962 (GRCm39) S1151R possibly damaging Het
Csta2 A G 16: 36,073,459 (GRCm39) E15G probably damaging Het
Degs1l T A 1: 180,882,463 (GRCm39) V75E possibly damaging Het
Dnajc2 T C 5: 21,988,061 (GRCm39) D6G probably damaging Het
Eif3a G A 19: 60,751,664 (GRCm39) probably benign Het
Fbn1 C A 2: 125,254,633 (GRCm39) C210F possibly damaging Het
Fmn2 T A 1: 174,523,286 (GRCm39) D1380E probably damaging Het
Fry A T 5: 150,304,375 (GRCm39) K588N probably damaging Het
Gm18856 G A 13: 14,139,805 (GRCm39) probably benign Het
Gpr37 G T 6: 25,688,686 (GRCm39) T137K probably benign Het
Gzmc T C 14: 56,472,039 (GRCm39) M1V probably null Het
Htr5a T C 5: 28,047,958 (GRCm39) V171A probably benign Het
Ints6l T C X: 55,500,557 (GRCm39) probably benign Het
Kcnma1 C T 14: 23,436,327 (GRCm39) probably null Het
Krt35 C T 11: 99,983,899 (GRCm39) G367D probably benign Het
Nlrp1b C T 11: 71,063,057 (GRCm39) V668I possibly damaging Het
Nlrp1b C T 11: 71,072,878 (GRCm39) V322I possibly damaging Het
Ntf3 T C 6: 126,078,823 (GRCm39) N228D probably damaging Het
Nup133 G A 8: 124,655,994 (GRCm39) R496W possibly damaging Het
Or4c10 T C 2: 89,760,903 (GRCm39) V250A probably benign Het
Or51i1 C A 7: 103,671,463 (GRCm39) G21W probably damaging Het
Pah C T 10: 87,414,707 (GRCm39) probably benign Het
Pan2 G T 10: 128,154,896 (GRCm39) W1112L probably damaging Het
Pkn3 G A 2: 29,970,879 (GRCm39) R209Q probably damaging Het
Plaa C T 4: 94,470,717 (GRCm39) probably null Het
Qprt C T 7: 126,708,027 (GRCm39) A135T probably damaging Het
Rbbp6 T G 7: 122,582,204 (GRCm39) S108A probably damaging Het
Smg1 T A 7: 117,795,117 (GRCm39) probably benign Het
Spink5 T A 18: 44,125,235 (GRCm39) C368S possibly damaging Het
Sptan1 T A 2: 29,908,486 (GRCm39) I1734N probably damaging Het
Stk38l C T 6: 146,669,031 (GRCm39) L170F probably damaging Het
Tjp1 A T 7: 64,949,530 (GRCm39) C1697* probably null Het
Tmco4 T C 4: 138,785,690 (GRCm39) S587P probably benign Het
Tmem208 G A 8: 106,055,329 (GRCm39) probably null Het
Trim30d T C 7: 104,121,623 (GRCm39) Q224R probably damaging Het
Trpm7 T A 2: 126,682,699 (GRCm39) D390V probably damaging Het
Uba7 A G 9: 107,858,589 (GRCm39) I807V probably benign Het
Utp18 C A 11: 93,759,160 (GRCm39) C438F probably damaging Het
Vps13d T C 4: 144,899,707 (GRCm39) K191E possibly damaging Het
Wdr27 A G 17: 15,146,453 (GRCm39) S181P probably damaging Het
Zfp462 T C 4: 55,010,613 (GRCm39) Y860H probably damaging Het
Other mutations in Tesmin
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0207:Tesmin UTSW 19 3,454,088 (GRCm39) missense probably benign 0.00
R2441:Tesmin UTSW 19 3,452,577 (GRCm39) critical splice donor site probably null
R5139:Tesmin UTSW 19 3,456,934 (GRCm39) missense probably damaging 1.00
R5272:Tesmin UTSW 19 3,456,992 (GRCm39) missense probably damaging 1.00
R6077:Tesmin UTSW 19 3,439,260 (GRCm39) missense possibly damaging 0.49
R7246:Tesmin UTSW 19 3,456,965 (GRCm39) missense probably damaging 1.00
R7357:Tesmin UTSW 19 3,447,042 (GRCm39) missense probably benign 0.04
R7567:Tesmin UTSW 19 3,442,218 (GRCm39) missense possibly damaging 0.94
R8419:Tesmin UTSW 19 3,439,077 (GRCm39) missense probably benign 0.03
R8782:Tesmin UTSW 19 3,445,965 (GRCm39) missense probably benign 0.01
R8922:Tesmin UTSW 19 3,454,163 (GRCm39) missense probably damaging 1.00
R9047:Tesmin UTSW 19 3,439,431 (GRCm39) intron probably benign
R9241:Tesmin UTSW 19 3,439,010 (GRCm39) missense probably benign 0.03
Posted On 2015-04-16