Incidental Mutation 'IGL02541:Or2ag2b'
ID 298242
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2ag2b
Ensembl Gene ENSMUSG00000036744
Gene Name olfactory receptor family 2 subfamily AG member 2B
Synonyms 4933433E02Rik, Olfr701, GA_x6K02T2PBJ9-9195805-9196755, 4932441H21Rik, MOR283-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL02541
Quality Score
Status
Chromosome 7
Chromosomal Location 106413336-106419916 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106417809 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 173 (E173G)
Ref Sequence ENSEMBL: ENSMUSP00000151783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075414] [ENSMUST00000080899] [ENSMUST00000166880] [ENSMUST00000217739] [ENSMUST00000219803]
AlphaFold Q9D3U9
Predicted Effect probably benign
Transcript: ENSMUST00000075414
AA Change: E173G

PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000074868
Gene: ENSMUSG00000036744
AA Change: E173G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-46 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080899
SMART Domains Protein: ENSMUSP00000079704
Gene: ENSMUSG00000056863

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 300 2.9e-8 PFAM
Pfam:7tm_1 41 290 1.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166880
AA Change: E173G

PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000130958
Gene: ENSMUSG00000036744
AA Change: E173G

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 5.8e-31 PFAM
Pfam:7tm_4 139 283 1.8e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209339
Predicted Effect probably benign
Transcript: ENSMUST00000217739
AA Change: E173G

PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000219803
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A T 7: 120,113,881 (GRCm39) L917F possibly damaging Het
Abca6 A T 11: 110,103,093 (GRCm39) W833R probably damaging Het
Asb15 T A 6: 24,566,265 (GRCm39) V406D probably damaging Het
Bcl9l T C 9: 44,419,066 (GRCm39) V968A probably benign Het
Bend7 T C 2: 4,768,116 (GRCm39) probably null Het
Cadm2 C A 16: 66,679,770 (GRCm39) G21V possibly damaging Het
Cadm2 C A 16: 66,679,771 (GRCm39) probably null Het
Camta1 G A 4: 151,169,112 (GRCm39) T1191I probably benign Het
Cep152 C T 2: 125,447,274 (GRCm39) A425T probably damaging Het
Cep95 C A 11: 106,706,407 (GRCm39) Q554K probably damaging Het
Cgref1 A G 5: 31,091,502 (GRCm39) probably null Het
Clock T A 5: 76,410,519 (GRCm39) probably null Het
Cmc2 A G 8: 117,620,883 (GRCm39) F33L probably benign Het
Cnksr3 A G 10: 7,085,073 (GRCm39) V258A probably damaging Het
Col6a6 G T 9: 105,609,415 (GRCm39) N1624K probably benign Het
Cped1 T C 6: 22,120,988 (GRCm39) I356T probably benign Het
Dpy19l2 C T 9: 24,569,943 (GRCm39) V337I probably benign Het
E2f3 A T 13: 30,100,827 (GRCm39) probably null Het
Eif1ad A G 19: 5,418,445 (GRCm39) probably benign Het
Fam114a2 A T 11: 57,390,627 (GRCm39) D302E probably benign Het
Fign T C 2: 63,809,881 (GRCm39) N463S probably benign Het
Fzr1 T C 10: 81,205,867 (GRCm39) T220A probably damaging Het
Gm14496 G A 2: 181,642,186 (GRCm39) R619Q probably benign Het
Gm9966 T C 7: 95,607,991 (GRCm39) I104T unknown Het
Itgb7 G T 15: 102,131,892 (GRCm39) H230Q probably benign Het
Kif7 T C 7: 79,360,628 (GRCm39) H249R possibly damaging Het
Krtap4-2 T G 11: 99,525,792 (GRCm39) Q20P unknown Het
Mis18bp1 T C 12: 65,208,234 (GRCm39) T160A probably damaging Het
Mrps9 T C 1: 42,901,814 (GRCm39) probably null Het
Mynn T A 3: 30,665,752 (GRCm39) H461Q probably damaging Het
Naa25 A G 5: 121,562,594 (GRCm39) T459A possibly damaging Het
Niban3 A T 8: 72,055,426 (GRCm39) T279S probably benign Het
Notch1 C T 2: 26,358,515 (GRCm39) D1439N probably benign Het
Pals2 A G 6: 50,160,707 (GRCm39) I323V probably benign Het
Pcdhb3 A T 18: 37,435,198 (GRCm39) D388V probably damaging Het
Pold3 C T 7: 99,732,879 (GRCm39) G417S probably damaging Het
Pwwp3a G A 10: 80,064,273 (GRCm39) probably null Het
Rad17 A G 13: 100,769,951 (GRCm39) probably benign Het
Sh3glb1 T C 3: 144,425,801 (GRCm39) D5G probably damaging Het
Shank3 T A 15: 89,385,613 (GRCm39) Y167N probably damaging Het
Slc3a2 A T 19: 8,685,123 (GRCm39) Y292* probably null Het
Slc7a13 T A 4: 19,839,212 (GRCm39) probably benign Het
Snx18 A T 13: 113,731,302 (GRCm39) I564N probably damaging Het
Supt6 G A 11: 78,117,744 (GRCm39) R491C probably damaging Het
Tanc1 G T 2: 59,663,602 (GRCm39) G1120C probably damaging Het
Tnrc6b C A 15: 80,764,032 (GRCm39) D511E probably benign Het
Trio A G 15: 27,845,016 (GRCm39) probably benign Het
Trmt12 T A 15: 58,745,651 (GRCm39) W350R probably benign Het
Ttc1 T C 11: 43,629,648 (GRCm39) T173A probably benign Het
Ttc39d C A 17: 80,523,875 (GRCm39) T178K probably damaging Het
Ufl1 T A 4: 25,250,534 (GRCm39) E693V possibly damaging Het
Vamp2 G T 11: 68,979,977 (GRCm39) E16D unknown Het
Vmn2r-ps158 T A 7: 42,673,092 (GRCm39) probably benign Het
Wdr70 C T 15: 7,913,783 (GRCm39) W622* probably null Het
Zfp28 C T 7: 6,396,479 (GRCm39) Q305* probably null Het
Zfp653 C A 9: 21,967,079 (GRCm39) R602L probably damaging Het
Zzef1 T A 11: 72,763,475 (GRCm39) V1374E probably damaging Het
Other mutations in Or2ag2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Or2ag2b APN 7 106,417,827 (GRCm39) missense probably damaging 1.00
IGL01972:Or2ag2b APN 7 106,417,739 (GRCm39) missense probably benign 0.01
R0276:Or2ag2b UTSW 7 106,417,904 (GRCm39) missense probably benign 0.00
R0345:Or2ag2b UTSW 7 106,417,908 (GRCm39) missense probably benign 0.38
R0467:Or2ag2b UTSW 7 106,417,568 (GRCm39) missense possibly damaging 0.49
R1829:Or2ag2b UTSW 7 106,418,214 (GRCm39) missense probably benign
R3116:Or2ag2b UTSW 7 106,417,571 (GRCm39) missense probably damaging 0.98
R3870:Or2ag2b UTSW 7 106,418,047 (GRCm39) nonsense probably null
R5267:Or2ag2b UTSW 7 106,418,015 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R7229:Or2ag2b UTSW 7 106,418,202 (GRCm39) missense probably damaging 0.97
R7230:Or2ag2b UTSW 7 106,417,386 (GRCm39) missense possibly damaging 0.78
R7231:Or2ag2b UTSW 7 106,417,650 (GRCm39) missense probably damaging 1.00
R7419:Or2ag2b UTSW 7 106,417,551 (GRCm39) missense possibly damaging 0.89
R7537:Or2ag2b UTSW 7 106,417,581 (GRCm39) missense probably damaging 1.00
R8468:Or2ag2b UTSW 7 106,418,046 (GRCm39) missense possibly damaging 0.66
R9246:Or2ag2b UTSW 7 106,417,938 (GRCm39) missense probably benign 0.00
R9300:Or2ag2b UTSW 7 106,418,111 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16