Incidental Mutation 'IGL02558:Zfp13'
ID298370
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp13
Ensembl Gene ENSMUSG00000062012
Gene Namezinc finger protein 13
SynonymsZfp-13, Krox-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.132) question?
Stock #IGL02558
Quality Score
Status
Chromosome17
Chromosomal Location23575844-23599487 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 23576098 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 493 (A493T)
Ref Sequence ENSEMBL: ENSMUSP00000054595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057029] [ENSMUST00000115516] [ENSMUST00000227952]
Predicted Effect probably benign
Transcript: ENSMUST00000057029
AA Change: A493T

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T

DomainStartEndE-ValueType
KRAB 117 179 7.54e-10 SMART
ZnF_C2H2 259 281 7.37e-4 SMART
ZnF_C2H2 287 309 1.2e-3 SMART
ZnF_C2H2 315 337 5.9e-3 SMART
ZnF_C2H2 343 365 1.26e-2 SMART
ZnF_C2H2 371 393 9.73e-4 SMART
ZnF_C2H2 399 421 2.12e-4 SMART
ZnF_C2H2 427 449 1.18e-2 SMART
ZnF_C2H2 455 477 6.52e-5 SMART
low complexity region 480 503 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000115516
AA Change: A500T
SMART Domains Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T

DomainStartEndE-ValueType
KRAB 124 186 7.54e-10 SMART
ZnF_C2H2 266 288 7.37e-4 SMART
ZnF_C2H2 294 316 1.2e-3 SMART
ZnF_C2H2 322 344 5.9e-3 SMART
ZnF_C2H2 350 372 1.26e-2 SMART
ZnF_C2H2 378 400 9.73e-4 SMART
ZnF_C2H2 406 428 2.12e-4 SMART
ZnF_C2H2 434 456 1.18e-2 SMART
ZnF_C2H2 462 484 6.52e-5 SMART
low complexity region 487 510 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226550
Predicted Effect probably benign
Transcript: ENSMUST00000227952
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228942
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik A C 5: 3,582,194 *25C probably null Het
Abca13 T C 11: 9,399,387 Y3654H probably damaging Het
Ankle1 T C 8: 71,408,992 F438S probably damaging Het
Atp10a A T 7: 58,819,642 R1080S probably damaging Het
Ccdc51 A T 9: 109,092,184 N380Y probably damaging Het
Ccr8 A T 9: 120,094,658 I280F probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cep162 G T 9: 87,225,726 T537N probably benign Het
Cep162 T C 9: 87,225,733 T535A probably benign Het
Cfap52 T C 11: 67,954,138 D35G probably benign Het
Cmip G A 8: 117,449,088 S530N probably damaging Het
Col9a3 A T 2: 180,606,806 probably null Het
Csf3r T C 4: 126,038,135 probably benign Het
Csk C T 9: 57,630,263 E123K probably benign Het
Csrnp3 G A 2: 66,022,229 E322K probably damaging Het
Ddx11 A T 17: 66,148,672 I663F probably damaging Het
Dnah1 T A 14: 31,274,379 M2667L possibly damaging Het
Foxred1 T C 9: 35,210,133 K40E probably damaging Het
Gata2 C T 6: 88,199,780 P74S probably benign Het
Gdf10 T G 14: 33,923,980 C29G probably benign Het
Hectd4 A G 5: 121,344,785 E3133G probably benign Het
Ints8 G A 4: 11,218,771 R784W probably damaging Het
Lrriq1 T C 10: 103,146,283 E1392G probably damaging Het
Muc19 T C 15: 91,897,622 noncoding transcript Het
Myom2 A T 8: 15,114,237 D1044V probably benign Het
Nphp4 G T 4: 152,555,531 R958L probably damaging Het
Nup205 C T 6: 35,189,924 P293S probably damaging Het
Olfr1130 T C 2: 87,607,559 I57T probably benign Het
Olfr23 A T 11: 73,940,825 H193L probably benign Het
Plxdc2 A G 2: 16,669,598 probably benign Het
Pwp2 T C 10: 78,179,065 S362G probably damaging Het
Siglec1 G T 2: 131,074,995 S1113R possibly damaging Het
Sirpa A G 2: 129,630,069 E472G probably damaging Het
Slc39a4 G T 15: 76,614,203 L345M probably damaging Het
Snx27 C T 3: 94,502,881 R496Q probably damaging Het
Stard9 A G 2: 120,696,907 H1215R possibly damaging Het
Stau1 A G 2: 166,950,848 Y371H probably benign Het
Sult2a1 A C 7: 13,832,595 W152G probably benign Het
Syt16 A T 12: 74,235,058 K319* probably null Het
Tcf7 T A 11: 52,253,970 probably benign Het
Tfdp1 A G 8: 13,369,546 N92D possibly damaging Het
Other mutations in Zfp13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02236:Zfp13 APN 17 23580765 splice site probably benign
IGL02447:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02449:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02450:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02466:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02468:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02471:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02473:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02474:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02475:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02491:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02511:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL03030:Zfp13 APN 17 23580845 missense probably benign 0.01
IGL03388:Zfp13 APN 17 23576914 missense probably benign 0.00
R0053:Zfp13 UTSW 17 23576148 missense probably damaging 1.00
R0053:Zfp13 UTSW 17 23576148 missense probably damaging 1.00
R1514:Zfp13 UTSW 17 23576412 missense probably damaging 1.00
R2420:Zfp13 UTSW 17 23576212 missense probably damaging 1.00
R3433:Zfp13 UTSW 17 23576628 missense probably damaging 0.99
R4458:Zfp13 UTSW 17 23581176 missense probably benign 0.01
R4650:Zfp13 UTSW 17 23580138 missense probably damaging 1.00
R4824:Zfp13 UTSW 17 23576823 missense possibly damaging 0.95
R5088:Zfp13 UTSW 17 23577061 nonsense probably null
R5110:Zfp13 UTSW 17 23580860 missense probably benign 0.02
R5384:Zfp13 UTSW 17 23581182 missense probably damaging 1.00
R7302:Zfp13 UTSW 17 23581062 missense probably damaging 1.00
Posted On2015-04-16