Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02558:Sult2a1'

298371

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sult2a1

Ensembl Gene

ENSMUSG00000078798

Gene Name

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

Synonyms

Std, Sth1, mSTa1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL02558

Quality Score

Status

Chromosome

Chromosomal Location

13530171-13571334 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 13566520 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Glycine at position 152 (W152G)

Ref Sequence

ENSEMBL: ENSMUSP00000104162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108522]

AlphaFold

P52843

Predicted Effect

probably benign
Transcript: ENSMUST00000108522
AA Change: W152G

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000104162
Gene: ENSMUSG00000078798
AA Change: W152G

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	34	278	4.6e-83	PFAM
Pfam:Sulfotransfer_3	35	205	5.8e-11	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	A	C	5: 3,632,194 (GRCm39)	*25C	probably null	Het
Abca13	T	C	11: 9,349,387 (GRCm39)	Y3654H	probably damaging	Het
Ankle1	T	C	8: 71,861,636 (GRCm39)	F438S	probably damaging	Het
Atp10a	A	T	7: 58,469,390 (GRCm39)	R1080S	probably damaging	Het
Ccdc51	A	T	9: 108,921,252 (GRCm39)	N380Y	probably damaging	Het
Ccr8	A	T	9: 119,923,724 (GRCm39)	I280F	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cep162	T	C	9: 87,107,786 (GRCm39)	T535A	probably benign	Het
Cep162	G	T	9: 87,107,779 (GRCm39)	T537N	probably benign	Het
Cfap52	T	C	11: 67,844,964 (GRCm39)	D35G	probably benign	Het
Cmip	G	A	8: 118,175,827 (GRCm39)	S530N	probably damaging	Het
Col9a3	A	T	2: 180,248,599 (GRCm39)		probably null	Het
Csf3r	T	C	4: 125,931,928 (GRCm39)		probably benign	Het
Csk	C	T	9: 57,537,546 (GRCm39)	E123K	probably benign	Het
Csrnp3	G	A	2: 65,852,573 (GRCm39)	E322K	probably damaging	Het
Ddx11	A	T	17: 66,455,667 (GRCm39)	I663F	probably damaging	Het
Dnah1	T	A	14: 30,996,336 (GRCm39)	M2667L	possibly damaging	Het
Foxred1	T	C	9: 35,121,429 (GRCm39)	K40E	probably damaging	Het
Gata2	C	T	6: 88,176,762 (GRCm39)	P74S	probably benign	Het
Gdf10	T	G	14: 33,645,937 (GRCm39)	C29G	probably benign	Het
Hectd4	A	G	5: 121,482,848 (GRCm39)	E3133G	probably benign	Het
Ints8	G	A	4: 11,218,771 (GRCm39)	R784W	probably damaging	Het
Lrriq1	T	C	10: 102,982,144 (GRCm39)	E1392G	probably damaging	Het
Muc19	T	C	15: 91,781,816 (GRCm39)		noncoding transcript	Het
Myom2	A	T	8: 15,164,237 (GRCm39)	D1044V	probably benign	Het
Nphp4	G	T	4: 152,639,988 (GRCm39)	R958L	probably damaging	Het
Nup205	C	T	6: 35,166,859 (GRCm39)	P293S	probably damaging	Het
Or10ag60	T	C	2: 87,437,903 (GRCm39)	I57T	probably benign	Het
Or1e17	A	T	11: 73,831,651 (GRCm39)	H193L	probably benign	Het
Plxdc2	A	G	2: 16,674,409 (GRCm39)		probably benign	Het
Pwp2	T	C	10: 78,014,899 (GRCm39)	S362G	probably damaging	Het
Siglec1	G	T	2: 130,916,915 (GRCm39)	S1113R	possibly damaging	Het
Sirpa	A	G	2: 129,471,989 (GRCm39)	E472G	probably damaging	Het
Slc39a4	G	T	15: 76,498,403 (GRCm39)	L345M	probably damaging	Het
Snx27	C	T	3: 94,410,188 (GRCm39)	R496Q	probably damaging	Het
Stard9	A	G	2: 120,527,388 (GRCm39)	H1215R	possibly damaging	Het
Stau1	A	G	2: 166,792,768 (GRCm39)	Y371H	probably benign	Het
Syt16	A	T	12: 74,281,832 (GRCm39)	K319*	probably null	Het
Tcf7	T	A	11: 52,144,797 (GRCm39)		probably benign	Het
Tfdp1	A	G	8: 13,419,546 (GRCm39)	N92D	possibly damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het

Other mutations in Sult2a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00896:Sult2a1	APN	7	13,566,565 (GRCm39)	missense	probably benign	0.02
IGL00990:Sult2a1	APN	7	13,537,961 (GRCm39)	missense	probably benign
IGL01322:Sult2a1	APN	7	13,566,604 (GRCm39)	nonsense	probably null
IGL03033:Sult2a1	APN	7	13,566,635 (GRCm39)	splice site	probably benign
IGL03199:Sult2a1	APN	7	13,566,585 (GRCm39)	missense	probably damaging	1.00
R1633:Sult2a1	UTSW	7	13,535,351 (GRCm39)	missense	probably benign	0.01
R1903:Sult2a1	UTSW	7	13,569,900 (GRCm39)	missense	possibly damaging	0.94
R2295:Sult2a1	UTSW	7	13,569,884 (GRCm39)	critical splice donor site	probably null
R4207:Sult2a1	UTSW	7	13,535,472 (GRCm39)	missense	probably benign	0.00
R5444:Sult2a1	UTSW	7	13,569,944 (GRCm39)	missense	possibly damaging	0.80
R6233:Sult2a1	UTSW	7	13,566,600 (GRCm39)	missense	probably damaging	1.00
R6317:Sult2a1	UTSW	7	13,569,945 (GRCm39)	missense	probably benign	0.00
R6853:Sult2a1	UTSW	7	13,535,412 (GRCm39)	missense	possibly damaging	0.50
R7098:Sult2a1	UTSW	7	13,549,978 (GRCm39)	splice site	probably null
R8948:Sult2a1	UTSW	7	13,530,342 (GRCm39)	missense	probably damaging	0.99
R8950:Sult2a1	UTSW	7	13,530,342 (GRCm39)	missense	probably damaging	0.99
R9207:Sult2a1	UTSW	7	13,566,627 (GRCm39)	missense	probably benign	0.40
Z1088:Sult2a1	UTSW	7	13,537,961 (GRCm39)	missense	probably benign
Z1088:Sult2a1	UTSW	7	13,535,360 (GRCm39)	missense	probably benign	0.00
Z1088:Sult2a1	UTSW	7	13,535,339 (GRCm39)	missense	probably benign
Z1176:Sult2a1	UTSW	7	13,537,961 (GRCm39)	missense	probably benign
Z1176:Sult2a1	UTSW	7	13,535,360 (GRCm39)	missense	probably benign	0.00
Z1176:Sult2a1	UTSW	7	13,535,339 (GRCm39)	missense	probably benign
Z1176:Sult2a1	UTSW	7	13,569,892 (GRCm39)	missense	probably damaging	1.00
Z1177:Sult2a1	UTSW	7	13,535,360 (GRCm39)	missense	probably benign	0.00
Z1177:Sult2a1	UTSW	7	13,535,339 (GRCm39)	missense	probably benign
Z1177:Sult2a1	UTSW	7	13,530,288 (GRCm39)	frame shift	probably null
Z1177:Sult2a1	UTSW	7	13,537,961 (GRCm39)	missense	probably benign

Posted On

2015-04-16