Incidental Mutation 'IGL02555:Ighv5-15'
ID298468
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ighv5-15
Ensembl Gene ENSMUSG00000094134
Gene Nameimmunoglobulin heavy variable 5-15
SynonymsGm16888
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02555
Quality Score
Status
Chromosome12
Chromosomal Location113826646-113827129 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 113827115 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 3 (F3L)
Ref Sequence ENSEMBL: ENSMUSP00000141493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103457] [ENSMUST00000192877]
Predicted Effect probably benign
Transcript: ENSMUST00000103457
AA Change: F3L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000100238
Gene: ENSMUSG00000094134
AA Change: F3L

DomainStartEndE-ValueType
IGv 35 116 2.17e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000192877
AA Change: F3L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000141493
Gene: ENSMUSG00000094134
AA Change: F3L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 36 117 9e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195115
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010109I03Rik G T 15: 74,881,608 probably benign Het
Actr1b G A 1: 36,701,747 R199C probably damaging Het
Adam9 T C 8: 24,966,736 N661D probably damaging Het
Amy1 C T 3: 113,564,892 E164K probably benign Het
Arid5b A C 10: 68,101,904 D221E probably benign Het
B3galt1 G T 2: 68,118,561 V207F probably benign Het
Begain A G 12: 109,034,189 S219P probably damaging Het
Clip1 A G 5: 123,621,794 probably null Het
Cps1 A G 1: 67,214,021 K1224R probably benign Het
Dnm1 A G 2: 32,328,038 Y449H probably damaging Het
Epas1 A T 17: 86,829,064 M755L probably benign Het
F13b T C 1: 139,517,186 C525R probably damaging Het
Fmnl2 A G 2: 53,126,851 probably null Het
Gm5346 A T 8: 43,625,268 C640S probably damaging Het
Inpp4a A G 1: 37,379,968 Q538R possibly damaging Het
Insrr A T 3: 87,813,817 M1092L probably damaging Het
Itgb8 C T 12: 119,189,881 V300M probably damaging Het
Kcnk5 A T 14: 20,141,985 H369Q probably benign Het
Olfr1023 G A 2: 85,887,398 M199I probably benign Het
Olfr1249 G A 2: 89,630,203 R232C probably damaging Het
Olfr1294 A G 2: 111,537,917 V124A probably damaging Het
Olfr24 T A 9: 18,755,473 H54L probably benign Het
Plxdc2 A G 2: 16,729,341 I417M probably benign Het
Polr1a G A 6: 71,920,457 E186K probably damaging Het
Ppp3cb A T 14: 20,530,953 F134L probably damaging Het
Prox2 C T 12: 85,095,260 W56* probably null Het
Scaf4 C T 16: 90,250,305 A395T unknown Het
Sh3tc2 G T 18: 61,990,237 A690S probably damaging Het
Slc34a1 T C 13: 55,401,168 S144P possibly damaging Het
Slc6a6 C T 6: 91,748,330 probably benign Het
Tubgcp3 A T 8: 12,639,595 M557K probably benign Het
Vmn2r103 A T 17: 19,811,611 D549V probably damaging Het
Washc2 T A 6: 116,209,100 N90K probably damaging Het
Posted On2015-04-16