Incidental Mutation 'IGL02555:Or1m1'
ID 298481
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1m1
Ensembl Gene ENSMUSG00000054141
Gene Name olfactory receptor family 1 subfamily M member 1
Synonyms GA_x6K02T2PVTD-12498544-12497603, MTPCR51, Olfr24, MOR132-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # IGL02555
Quality Score
Status
Chromosome 9
Chromosomal Location 18665988-18666929 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18666769 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 54 (H54L)
Ref Sequence ENSEMBL: ENSMUSP00000149702 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066997] [ENSMUST00000216754]
AlphaFold Q8VFM9
Predicted Effect probably benign
Transcript: ENSMUST00000066997
AA Change: H54L

PolyPhen 2 Score 0.404 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000064189
Gene: ENSMUSG00000054141
AA Change: H54L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.6e-64 PFAM
Pfam:7TM_GPCR_Srsx 35 304 9.2e-9 PFAM
Pfam:7tm_1 41 290 3.2e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212239
AA Change: H54L
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214366
Predicted Effect probably benign
Transcript: ENSMUST00000216754
AA Change: H54L

PolyPhen 2 Score 0.404 (Sensitivity: 0.89; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr1b G A 1: 36,740,828 (GRCm39) R199C probably damaging Het
Adam34l A T 8: 44,078,305 (GRCm39) C640S probably damaging Het
Adam9 T C 8: 25,456,752 (GRCm39) N661D probably damaging Het
Amy1 C T 3: 113,358,541 (GRCm39) E164K probably benign Het
Arid5b A C 10: 67,937,734 (GRCm39) D221E probably benign Het
B3galt1 G T 2: 67,948,905 (GRCm39) V207F probably benign Het
Begain A G 12: 109,000,115 (GRCm39) S219P probably damaging Het
Clip1 A G 5: 123,759,857 (GRCm39) probably null Het
Cps1 A G 1: 67,253,180 (GRCm39) K1224R probably benign Het
Dnm1 A G 2: 32,218,050 (GRCm39) Y449H probably damaging Het
Epas1 A T 17: 87,136,492 (GRCm39) M755L probably benign Het
F13b T C 1: 139,444,924 (GRCm39) C525R probably damaging Het
Fmnl2 A G 2: 53,016,863 (GRCm39) probably null Het
Ighv5-15 A G 12: 113,790,735 (GRCm39) F3L probably benign Het
Inpp4a A G 1: 37,419,049 (GRCm39) Q538R possibly damaging Het
Insrr A T 3: 87,721,124 (GRCm39) M1092L probably damaging Het
Itgb8 C T 12: 119,153,616 (GRCm39) V300M probably damaging Het
Kcnk5 A T 14: 20,192,053 (GRCm39) H369Q probably benign Het
Ly6m G T 15: 74,753,457 (GRCm39) probably benign Het
Or4a76 G A 2: 89,460,547 (GRCm39) R232C probably damaging Het
Or4k44 A G 2: 111,368,262 (GRCm39) V124A probably damaging Het
Or5m10 G A 2: 85,717,742 (GRCm39) M199I probably benign Het
Plxdc2 A G 2: 16,734,152 (GRCm39) I417M probably benign Het
Polr1a G A 6: 71,897,441 (GRCm39) E186K probably damaging Het
Ppp3cb A T 14: 20,581,021 (GRCm39) F134L probably damaging Het
Prox2 C T 12: 85,142,034 (GRCm39) W56* probably null Het
Scaf4 C T 16: 90,047,193 (GRCm39) A395T unknown Het
Sh3tc2 G T 18: 62,123,308 (GRCm39) A690S probably damaging Het
Slc34a1 T C 13: 55,548,981 (GRCm39) S144P possibly damaging Het
Slc6a6 C T 6: 91,725,311 (GRCm39) probably benign Het
Tubgcp3 A T 8: 12,689,595 (GRCm39) M557K probably benign Het
Vmn2r103 A T 17: 20,031,873 (GRCm39) D549V probably damaging Het
Washc2 T A 6: 116,186,061 (GRCm39) N90K probably damaging Het
Other mutations in Or1m1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02346:Or1m1 APN 9 18,666,065 (GRCm39) missense probably damaging 0.97
IGL02371:Or1m1 APN 9 18,666,000 (GRCm39) missense probably benign 0.07
IGL03025:Or1m1 APN 9 18,666,665 (GRCm39) missense probably benign 0.00
IGL03259:Or1m1 APN 9 18,666,811 (GRCm39) missense probably benign
IGL03050:Or1m1 UTSW 9 18,666,750 (GRCm39) nonsense probably null
R0310:Or1m1 UTSW 9 18,666,629 (GRCm39) missense possibly damaging 0.91
R0410:Or1m1 UTSW 9 18,666,137 (GRCm39) missense probably damaging 0.96
R2152:Or1m1 UTSW 9 18,666,391 (GRCm39) missense probably damaging 1.00
R2153:Or1m1 UTSW 9 18,666,391 (GRCm39) missense probably damaging 1.00
R2918:Or1m1 UTSW 9 18,666,775 (GRCm39) missense probably damaging 1.00
R4552:Or1m1 UTSW 9 18,666,430 (GRCm39) missense possibly damaging 0.60
R5073:Or1m1 UTSW 9 18,666,118 (GRCm39) missense possibly damaging 0.89
R5539:Or1m1 UTSW 9 18,666,134 (GRCm39) missense probably damaging 0.99
R5662:Or1m1 UTSW 9 18,666,896 (GRCm39) missense probably damaging 0.99
R6145:Or1m1 UTSW 9 18,666,865 (GRCm39) missense probably benign 0.06
R7125:Or1m1 UTSW 9 18,666,174 (GRCm39) nonsense probably null
R7196:Or1m1 UTSW 9 18,666,886 (GRCm39) nonsense probably null
R7607:Or1m1 UTSW 9 18,666,178 (GRCm39) missense possibly damaging 0.93
R9136:Or1m1 UTSW 9 18,666,175 (GRCm39) missense probably damaging 1.00
Z1177:Or1m1 UTSW 9 18,666,815 (GRCm39) missense possibly damaging 0.85
Posted On 2015-04-16