Incidental Mutation 'IGL02559:Olfr666'
ID298597
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr666
Ensembl Gene ENSMUSG00000063582
Gene Nameolfactory receptor 666
SynonymsMOR34-1, GA_x6K02T2PBJ9-7522449-7521493
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.139) question?
Stock #IGL02559
Quality Score
Status
Chromosome7
Chromosomal Location104891822-104895952 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 104892954 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Tryptophan at position 225 (R225W)
Ref Sequence ENSEMBL: ENSMUSP00000148919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081116] [ENSMUST00000214757]
Predicted Effect probably benign
Transcript: ENSMUST00000081116
AA Change: R225W

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000079893
Gene: ENSMUSG00000063582
AA Change: R225W

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 2.7e-104 PFAM
Pfam:7TM_GPCR_Srsx 37 209 4.1e-11 PFAM
Pfam:7tm_1 43 295 1.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214757
AA Change: R225W

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp C T 16: 56,687,070 Q1004* probably null Het
Bahcc1 A G 11: 120,285,172 D1914G probably damaging Het
Bcl11b A T 12: 107,915,394 probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Col24a1 A T 3: 145,314,173 I102F probably benign Het
Col7a1 C T 9: 108,973,216 R2063C unknown Het
Ddo T A 10: 40,647,521 L169Q probably damaging Het
Defb4 G T 8: 19,201,297 C60F probably damaging Het
Dock9 A T 14: 121,625,147 probably benign Het
Dysf A T 6: 84,067,446 probably benign Het
Fasn G A 11: 120,809,066 A2253V possibly damaging Het
Fbxw26 T C 9: 109,722,164 D355G probably benign Het
Gak C T 5: 108,584,232 E797K probably null Het
Gm10654 T C 8: 70,932,130 noncoding transcript Het
Gnas T C 2: 174,341,936 probably benign Het
Hdac3 A G 18: 37,954,891 F8S probably damaging Het
Hist1h2bj T A 13: 22,043,363 V45E possibly damaging Het
Hrh4 T C 18: 13,007,244 probably null Het
Klhl1 A G 14: 96,151,960 V586A possibly damaging Het
Lct T C 1: 128,294,266 N1512S probably damaging Het
Mmp28 G T 11: 83,447,740 N128K probably benign Het
Mndal T C 1: 173,872,920 T162A probably benign Het
Myh3 A G 11: 67,101,095 E1822G possibly damaging Het
Mylpf A G 7: 127,214,143 Y133C probably damaging Het
Nup210l G A 3: 90,159,953 A767T probably benign Het
Olfr1404 T C 1: 173,216,521 V290A probably damaging Het
Olfr221 A G 14: 52,036,007 Y35H probably damaging Het
Paics A G 5: 76,964,604 I312V possibly damaging Het
Pkdrej G T 15: 85,817,848 Q1296K probably benign Het
Ppil2 T C 16: 17,109,651 K26E possibly damaging Het
Rufy1 A G 11: 50,420,483 F170L probably damaging Het
Shcbp1 T A 8: 4,749,305 E93V probably damaging Het
Slamf1 T A 1: 171,767,258 I11K possibly damaging Het
Slc5a5 C T 8: 70,890,271 G215D probably damaging Het
Slco1a1 A T 6: 141,921,788 V473D probably benign Het
Slit1 A G 19: 41,721,085 V123A probably benign Het
Srgap2 A C 1: 131,524,936 probably null Het
Stk32c T C 7: 139,120,690 M208V probably benign Het
Syt15 T C 14: 34,221,803 V103A probably benign Het
Tacc2 T A 7: 130,759,267 L456Q probably damaging Het
Tanc1 A G 2: 59,724,654 probably benign Het
Tepsin G T 11: 120,096,905 D62E probably benign Het
Thap3 T C 4: 151,983,687 D106G probably benign Het
Ttn T C 2: 76,786,217 D14818G probably damaging Het
Txndc2 T C 17: 65,639,590 N39S possibly damaging Het
Ubxn11 A G 4: 134,124,943 E200G probably damaging Het
Vmn2r11 T G 5: 109,052,180 Q469P probably damaging Het
Yipf2 T C 9: 21,592,186 T22A probably damaging Het
Other mutations in Olfr666
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Olfr666 APN 7 104892972 missense probably damaging 1.00
IGL01016:Olfr666 APN 7 104893036 missense probably damaging 1.00
IGL01577:Olfr666 APN 7 104893523 missense probably benign
IGL01775:Olfr666 APN 7 104893292 missense possibly damaging 0.95
IGL01932:Olfr666 APN 7 104893218 missense probably damaging 0.99
IGL03193:Olfr666 APN 7 104893056 missense probably benign 0.31
R0359:Olfr666 UTSW 7 104893314 missense probably damaging 0.99
R0494:Olfr666 UTSW 7 104893271 missense probably damaging 1.00
R0680:Olfr666 UTSW 7 104893004 missense probably benign 0.23
R1476:Olfr666 UTSW 7 104893237 nonsense probably null
R1988:Olfr666 UTSW 7 104892903 missense probably damaging 1.00
R2520:Olfr666 UTSW 7 104892873 missense probably benign 0.01
R3690:Olfr666 UTSW 7 104893517 missense possibly damaging 0.66
R5220:Olfr666 UTSW 7 104892897 missense possibly damaging 0.94
R5322:Olfr666 UTSW 7 104893164 missense probably benign 0.14
R5728:Olfr666 UTSW 7 104893229 missense possibly damaging 0.88
R6865:Olfr666 UTSW 7 104893512 missense probably benign 0.00
R7235:Olfr666 UTSW 7 104892719 missense probably benign 0.01
R7404:Olfr666 UTSW 7 104892974 missense possibly damaging 0.61
Posted On2015-04-16