Incidental Mutation 'IGL02565:Pglyrp4'
ID 298796
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp4
Ensembl Gene ENSMUSG00000042250
Gene Name peptidoglycan recognition protein 4
Synonyms LOC384997, LOC242097
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02565
Quality Score
Status
Chromosome 3
Chromosomal Location 90634213-90648824 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 90642794 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 225 (D225V)
Ref Sequence ENSEMBL: ENSMUSP00000128113 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047745] [ENSMUST00000169698]
AlphaFold Q0VB07
Predicted Effect probably benign
Transcript: ENSMUST00000047745
AA Change: D224V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000040755
Gene: ENSMUSG00000042250
AA Change: D224V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 213 1.14e-7 SMART
PGRP 212 353 2.13e-72 SMART
Ami_2 222 359 1.62e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156268
Predicted Effect probably benign
Transcript: ENSMUST00000169698
AA Change: D225V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000128113
Gene: ENSMUSG00000042250
AA Change: D225V

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 200 2.12e-7 SMART
PGRP 213 354 2.13e-72 SMART
Ami_2 223 360 1.62e-21 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921511C20Rik T A X: 126,302,677 (GRCm39) S205R probably benign Het
Adora3 A G 3: 105,815,128 (GRCm39) T293A probably benign Het
App T C 16: 84,822,308 (GRCm39) probably null Het
Asap1 A G 15: 64,001,014 (GRCm39) probably benign Het
Brinp3 T A 1: 146,777,770 (GRCm39) V739E probably damaging Het
Bsn A G 9: 107,990,487 (GRCm39) V1755A probably damaging Het
Clmp A C 9: 40,683,711 (GRCm39) D147A probably damaging Het
Cntn5 A T 9: 10,145,343 (GRCm39) C122* probably null Het
Ctsb T G 14: 63,375,859 (GRCm39) C198G probably null Het
Cyld A T 8: 89,467,919 (GRCm39) R702S probably damaging Het
Cyp4v3 A G 8: 45,773,674 (GRCm39) V165A possibly damaging Het
Dpy19l4 C A 4: 11,309,440 (GRCm39) V59F probably benign Het
Eml1 A T 12: 108,472,779 (GRCm39) T196S probably damaging Het
Fam111a T A 19: 12,564,318 (GRCm39) D22E probably damaging Het
Gigyf2 A G 1: 87,369,858 (GRCm39) H1150R probably damaging Het
Grk5 T G 19: 61,057,809 (GRCm39) F170V probably damaging Het
Heatr5a A C 12: 51,997,882 (GRCm39) V339G possibly damaging Het
Hgd T A 16: 37,435,749 (GRCm39) D153E possibly damaging Het
Ift70b A G 2: 75,768,247 (GRCm39) Y169H probably benign Het
Igdcc3 T A 9: 65,087,470 (GRCm39) L336Q probably damaging Het
Jph2 T C 2: 163,239,265 (GRCm39) E61G probably damaging Het
Ktn1 A T 14: 47,910,391 (GRCm39) probably benign Het
Lrch3 T A 16: 32,826,084 (GRCm39) D634E probably benign Het
Marchf6 T C 15: 31,490,712 (GRCm39) probably benign Het
Misp T A 10: 79,662,177 (GRCm39) I198N probably benign Het
Mmp14 C T 14: 54,678,014 (GRCm39) P545L probably benign Het
Mon1b G T 8: 114,365,455 (GRCm39) R261L possibly damaging Het
Muc5b T C 7: 141,411,604 (GRCm39) S1517P unknown Het
Nae1 A T 8: 105,237,841 (GRCm39) N518K probably damaging Het
Pgpep1 A G 8: 71,105,119 (GRCm39) I47T probably damaging Het
Pip5k1c C A 10: 81,153,155 (GRCm39) probably null Het
Pitpnc1 G A 11: 107,187,059 (GRCm39) T88I probably damaging Het
Poldip2 T C 11: 78,408,678 (GRCm39) I181T probably damaging Het
Ppfia2 T C 10: 106,699,247 (GRCm39) probably null Het
Rasal1 A G 5: 120,814,845 (GRCm39) probably benign Het
Rbms1 A G 2: 60,590,123 (GRCm39) Y305H probably benign Het
Rnf123 A C 9: 107,929,411 (GRCm39) probably null Het
Sec14l3 G A 11: 4,026,237 (GRCm39) probably benign Het
Slc2a10 A C 2: 165,357,000 (GRCm39) D220A probably damaging Het
Slc38a8 T C 8: 120,212,300 (GRCm39) T348A probably damaging Het
Slc4a5 T C 6: 83,276,487 (GRCm39) V1104A probably benign Het
Snrpe T C 1: 133,536,704 (GRCm39) probably benign Het
Th C A 7: 142,453,647 (GRCm39) V18F probably damaging Het
Ubqln5 G A 7: 103,778,279 (GRCm39) Q182* probably null Het
Unc5c T C 3: 141,509,680 (GRCm39) V646A probably damaging Het
Wasf1 A G 10: 40,812,128 (GRCm39) N306D possibly damaging Het
Other mutations in Pglyrp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Pglyrp4 APN 3 90,646,335 (GRCm39) missense probably damaging 1.00
IGL00575:Pglyrp4 APN 3 90,638,098 (GRCm39) missense probably damaging 1.00
IGL01892:Pglyrp4 APN 3 90,646,348 (GRCm39) missense probably benign 0.00
IGL02097:Pglyrp4 APN 3 90,642,910 (GRCm39) missense probably benign 0.01
IGL02159:Pglyrp4 APN 3 90,638,160 (GRCm39) missense possibly damaging 0.87
IGL02398:Pglyrp4 APN 3 90,646,424 (GRCm39) splice site probably benign
IGL02619:Pglyrp4 APN 3 90,642,955 (GRCm39) splice site probably null
R1160:Pglyrp4 UTSW 3 90,636,138 (GRCm39) splice site probably null
R1420:Pglyrp4 UTSW 3 90,636,021 (GRCm39) missense probably damaging 0.96
R1828:Pglyrp4 UTSW 3 90,640,310 (GRCm39) missense probably damaging 1.00
R4974:Pglyrp4 UTSW 3 90,640,314 (GRCm39) missense probably benign 0.04
R5268:Pglyrp4 UTSW 3 90,634,271 (GRCm39) missense probably damaging 1.00
R5704:Pglyrp4 UTSW 3 90,647,581 (GRCm39) splice site probably null
R7286:Pglyrp4 UTSW 3 90,640,281 (GRCm39) missense probably damaging 1.00
R7787:Pglyrp4 UTSW 3 90,640,295 (GRCm39) missense probably damaging 1.00
R8772:Pglyrp4 UTSW 3 90,647,707 (GRCm39) missense possibly damaging 0.54
R9132:Pglyrp4 UTSW 3 90,635,238 (GRCm39) nonsense probably null
R9607:Pglyrp4 UTSW 3 90,638,151 (GRCm39) missense probably damaging 1.00
Z1176:Pglyrp4 UTSW 3 90,646,312 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16