Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02567:Htr1f'

298865

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Htr1f

Ensembl Gene

ENSMUSG00000050783

Gene Name

5-hydroxytryptamine (serotonin) receptor 1F

Synonyms

Htr1eb

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02567

Quality Score

Status

Chromosome

Chromosomal Location

64745092-64926147 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 64746611 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 227 (G227D)

Ref Sequence

ENSEMBL: ENSMUSP00000063136 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063076]

AlphaFold

Q02284

Predicted Effect

probably benign
Transcript: ENSMUST00000063076
AA Change: G227D

PolyPhen 2 Score 0.446 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000063136
Gene: ENSMUSG00000050783
AA Change: G227D

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	32	230	4.8e-7	PFAM
Pfam:7TM_GPCR_Srsx	34	362	2.4e-10	PFAM
Pfam:7tm_1	40	347	4.1e-74	PFAM
Pfam:7TM_GPCR_Srv	54	249	5.2e-7	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aff4	C	A	11: 53,263,578 (GRCm39)	S199R	possibly damaging	Het
Ano1	A	G	7: 144,165,362 (GRCm39)	L621P	probably damaging	Het
Calcr	C	T	6: 3,691,564 (GRCm39)	V404M	probably damaging	Het
Carmil3	A	G	14: 55,736,339 (GRCm39)	S635G	possibly damaging	Het
Ccl12	C	A	11: 81,993,447 (GRCm39)	S28R	possibly damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdhr3	T	C	12: 33,088,900 (GRCm39)	N761D	probably benign	Het
Col14a1	T	C	15: 55,208,357 (GRCm39)		probably null	Het
Col28a1	T	C	6: 8,014,819 (GRCm39)	K862R	possibly damaging	Het
Cyp2c66	C	T	19: 39,175,084 (GRCm39)		probably benign	Het
D5Ertd615e	T	C	5: 45,320,758 (GRCm39)		noncoding transcript	Het
Deup1	T	C	9: 15,486,579 (GRCm39)	E367G	probably damaging	Het
Dpp8	T	G	9: 64,986,058 (GRCm39)	Y849*	probably null	Het
Efhc1	T	A	1: 21,043,188 (GRCm39)	V369E	probably damaging	Het
Entrep2	T	A	7: 64,436,479 (GRCm39)	M101L	possibly damaging	Het
Epg5	A	G	18: 78,076,288 (GRCm39)	Y2562C	probably damaging	Het
Fbln5	A	G	12: 101,728,059 (GRCm39)		probably null	Het
Frem1	A	T	4: 82,918,292 (GRCm39)	M551K	probably damaging	Het
Gba2	T	C	4: 43,567,281 (GRCm39)	S889G	probably benign	Het
Golph3	C	T	15: 12,349,507 (GRCm39)	R176*	probably null	Het
Got2	A	T	8: 96,598,829 (GRCm39)	F191Y	probably benign	Het
Gtf2ird2	G	T	5: 134,241,890 (GRCm39)		probably benign	Het
H4c16	G	A	6: 136,781,272 (GRCm39)	R36W	probably damaging	Het
Hivep3	A	G	4: 119,991,153 (GRCm39)	T2218A	probably damaging	Het
Ifi202b	C	T	1: 173,791,370 (GRCm39)	S436N	possibly damaging	Het
Nf1	T	A	11: 79,437,969 (GRCm39)	V2109D	probably damaging	Het
Opa1	C	A	16: 29,407,104 (GRCm39)	D29E	probably benign	Het
Papln	C	T	12: 83,825,611 (GRCm39)	P631S	probably benign	Het
Pde4c	T	A	8: 71,200,570 (GRCm39)	M352K	probably benign	Het
Pigu	T	C	2: 155,173,112 (GRCm39)	T129A	possibly damaging	Het
Pla2g4c	T	A	7: 13,079,965 (GRCm39)	H424Q	probably damaging	Het
Ptpn13	T	G	5: 103,710,157 (GRCm39)	L1564R	probably damaging	Het
Rbm5	T	C	9: 107,621,473 (GRCm39)	D642G	probably damaging	Het
Rnf111	T	C	9: 70,366,287 (GRCm39)	T384A	probably damaging	Het
Scn11a	T	C	9: 119,633,555 (GRCm39)	T393A	probably damaging	Het
Sned1	A	T	1: 93,202,069 (GRCm39)	K619M	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Syt9	A	G	7: 107,035,868 (GRCm39)	Y295C	probably damaging	Het
Taar7f	T	A	10: 23,926,323 (GRCm39)	Y306N	probably damaging	Het
Tmem107	T	G	11: 68,961,845 (GRCm39)	L25V	possibly damaging	Het
Wdr24	T	G	17: 26,043,322 (GRCm39)	I48S	probably damaging	Het
Zc3hc1	T	C	6: 30,374,848 (GRCm39)	D231G	probably benign	Het
Zfp142	T	C	1: 74,617,309 (GRCm39)	K341E	possibly damaging	Het
Zfp142	T	A	1: 74,617,306 (GRCm39)	S342C	possibly damaging	Het
Zfp142	T	G	1: 74,617,308 (GRCm39)	K341T	possibly damaging	Het
Zfp804b	T	A	5: 6,819,989 (GRCm39)	I989L	probably benign	Het
Zfyve9	A	C	4: 108,531,720 (GRCm39)	V1095G	probably damaging	Het

Other mutations in Htr1f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00896:Htr1f	APN	16	64,746,469 (GRCm39)	missense	probably benign	0.00
IGL01134:Htr1f	APN	16	64,746,501 (GRCm39)	missense	probably benign	0.00
IGL01455:Htr1f	APN	16	64,746,385 (GRCm39)	missense	probably damaging	1.00
IGL01580:Htr1f	APN	16	64,746,198 (GRCm39)	nonsense	probably null
IGL01865:Htr1f	APN	16	64,746,282 (GRCm39)	missense	probably damaging	1.00
IGL02027:Htr1f	APN	16	64,746,684 (GRCm39)	nonsense	probably null
IGL02234:Htr1f	APN	16	64,746,430 (GRCm39)	missense	probably damaging	1.00
R0035:Htr1f	UTSW	16	64,746,860 (GRCm39)	missense	probably damaging	1.00
R0131:Htr1f	UTSW	16	64,747,091 (GRCm39)	missense	probably damaging	1.00
R0131:Htr1f	UTSW	16	64,747,091 (GRCm39)	missense	probably damaging	1.00
R0132:Htr1f	UTSW	16	64,747,091 (GRCm39)	missense	probably damaging	1.00
R0193:Htr1f	UTSW	16	64,747,112 (GRCm39)	missense	probably damaging	1.00
R0523:Htr1f	UTSW	16	64,746,262 (GRCm39)	missense	probably damaging	1.00
R0722:Htr1f	UTSW	16	64,746,254 (GRCm39)	missense	probably damaging	0.99
R2055:Htr1f	UTSW	16	64,746,398 (GRCm39)	missense	probably damaging	1.00
R3418:Htr1f	UTSW	16	64,746,260 (GRCm39)	missense	probably damaging	1.00
R4090:Htr1f	UTSW	16	64,746,324 (GRCm39)	missense	probably benign	0.06
R4320:Htr1f	UTSW	16	64,747,050 (GRCm39)	missense	possibly damaging	0.87
R5037:Htr1f	UTSW	16	64,746,291 (GRCm39)	missense	probably damaging	1.00
R6004:Htr1f	UTSW	16	64,746,239 (GRCm39)	missense	probably damaging	1.00
R7383:Htr1f	UTSW	16	64,747,206 (GRCm39)	missense	probably benign	0.00
R7462:Htr1f	UTSW	16	64,746,383 (GRCm39)	missense	probably damaging	0.99
R7864:Htr1f	UTSW	16	64,747,157 (GRCm39)	missense	probably damaging	1.00
R8677:Htr1f	UTSW	16	64,746,414 (GRCm39)	missense	possibly damaging	0.69
R8816:Htr1f	UTSW	16	64,746,537 (GRCm39)	missense	probably benign	0.05
R8836:Htr1f	UTSW	16	64,747,196 (GRCm39)	missense	probably benign
R9106:Htr1f	UTSW	16	64,746,637 (GRCm39)	missense	probably damaging	1.00
R9155:Htr1f	UTSW	16	64,746,788 (GRCm39)	missense	probably benign	0.00
R9182:Htr1f	UTSW	16	64,746,825 (GRCm39)	missense	probably benign	0.03
R9244:Htr1f	UTSW	16	64,746,857 (GRCm39)	missense	probably benign	0.31
R9430:Htr1f	UTSW	16	64,746,831 (GRCm39)	missense	probably damaging	1.00
Z1176:Htr1f	UTSW	16	64,747,237 (GRCm39)	missense	probably benign
Z1176:Htr1f	UTSW	16	64,746,440 (GRCm39)	nonsense	probably null

Posted On

2015-04-16