Incidental Mutation 'IGL02570:Zfp935'
| ID |
298978 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp935
|
| Ensembl Gene |
ENSMUSG00000055228 |
| Gene Name |
zinc finger protein 935 |
| Synonyms |
8430426H19Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
IGL02570
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
62600830-62614626 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 62604792 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 29
(Y29H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152662
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076195]
[ENSMUST00000221747]
[ENSMUST00000223247]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076195
AA Change: Y29H
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000075552
Gene: ENSMUSG00000055228
AA Change: Y29H
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
8.26e-16 |
SMART |
|
ZnF_C2H2
|
133 |
155 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
161 |
183 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
189 |
211 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
245 |
267 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
273 |
295 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
1.2e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000221747
AA Change: Y29H
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221951
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000223247
AA Change: Y29H
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acat3 |
T |
C |
17: 13,159,181 (GRCm39) |
T3A |
probably benign |
Het |
| Anapc1 |
A |
C |
2: 128,487,120 (GRCm39) |
F1087V |
probably damaging |
Het |
| Ccdc158 |
T |
C |
5: 92,796,885 (GRCm39) |
T484A |
possibly damaging |
Het |
| Cps1 |
T |
C |
1: 67,187,862 (GRCm39) |
|
probably benign |
Het |
| Fscb |
A |
G |
12: 64,518,952 (GRCm39) |
I838T |
unknown |
Het |
| Gdap1 |
A |
G |
1: 17,215,709 (GRCm39) |
Q5R |
probably benign |
Het |
| Gmds |
A |
G |
13: 32,418,390 (GRCm39) |
|
probably benign |
Het |
| Gmfb |
A |
T |
14: 47,054,904 (GRCm39) |
D13E |
probably benign |
Het |
| Gpcpd1 |
A |
T |
2: 132,389,605 (GRCm39) |
V250D |
probably benign |
Het |
| Grin2b |
T |
C |
6: 135,899,996 (GRCm39) |
D295G |
probably damaging |
Het |
| Igkv1-135 |
A |
T |
6: 67,586,732 (GRCm39) |
M2L |
probably benign |
Het |
| Impdh1 |
T |
C |
6: 29,203,197 (GRCm39) |
Y375C |
probably damaging |
Het |
| Lrpprc |
A |
G |
17: 85,057,981 (GRCm39) |
Y750H |
probably damaging |
Het |
| Mab21l2 |
A |
T |
3: 86,454,531 (GRCm39) |
S156R |
possibly damaging |
Het |
| Map4k4 |
T |
C |
1: 40,019,739 (GRCm39) |
I146T |
probably benign |
Het |
| Pcdh18 |
A |
T |
3: 49,711,074 (GRCm39) |
N80K |
probably benign |
Het |
| Pkhd1 |
A |
G |
1: 20,590,480 (GRCm39) |
F1756L |
probably damaging |
Het |
| Plekhg3 |
A |
G |
12: 76,625,019 (GRCm39) |
E1287G |
probably benign |
Het |
| Rev3l |
T |
A |
10: 39,724,009 (GRCm39) |
V2647E |
possibly damaging |
Het |
| Rxfp4 |
A |
C |
3: 88,560,149 (GRCm39) |
S101A |
probably damaging |
Het |
| Spag4 |
A |
T |
2: 155,910,364 (GRCm39) |
H330L |
possibly damaging |
Het |
| Spef2 |
G |
A |
15: 9,717,584 (GRCm39) |
R254* |
probably null |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| Usp16 |
A |
G |
16: 87,277,781 (GRCm39) |
Y677C |
probably damaging |
Het |
| Vmn2r71 |
T |
A |
7: 85,264,748 (GRCm39) |
W27R |
possibly damaging |
Het |
| Vwa5a |
T |
C |
9: 38,646,167 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp935 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00791:Zfp935
|
APN |
13 |
62,602,278 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02169:Zfp935
|
APN |
13 |
62,604,745 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02756:Zfp935
|
APN |
13 |
62,602,701 (GRCm39) |
nonsense |
probably null |
|
|
IGL03338:Zfp935
|
APN |
13 |
62,602,247 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1252:Zfp935
|
UTSW |
13 |
62,602,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1503:Zfp935
|
UTSW |
13 |
62,602,951 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2425:Zfp935
|
UTSW |
13 |
62,602,922 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3720:Zfp935
|
UTSW |
13 |
62,602,846 (GRCm39) |
nonsense |
probably null |
|
|
R4819:Zfp935
|
UTSW |
13 |
62,602,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5391:Zfp935
|
UTSW |
13 |
62,602,632 (GRCm39) |
nonsense |
probably null |
|
|
R6253:Zfp935
|
UTSW |
13 |
62,602,685 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6742:Zfp935
|
UTSW |
13 |
62,602,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9447:Zfp935
|
UTSW |
13 |
62,602,842 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Posted On |
2015-04-16 |
Incidental Mutation