Mutagenetix > Incidental Mutation

Incidental Mutation 'R0357:Gm8674'

29900

Institutional Source

Beutler Lab

Gene Symbol

Gm8674

Ensembl Gene

ENSMUSG00000093976

Gene Name

predicted gene 8674

Synonyms

MMRRC Submission

038563-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R0357 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50053085-50056359 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to A at 50056149 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179367

SMART Domains

Protein: ENSMUSP00000137219
Gene: ENSMUSG00000093976

Domain	Start	End	E-Value	Type
low complexity region	70	86	N/A	INTRINSIC
Pfam:FAM75	92	444	3.6e-27	PFAM

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.0%
3x: 97.9%
10x: 95.3%
20x: 89.3%

Validation Efficiency

99% (74/75)

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf2	T	C	5: 24,778,463 (GRCm39)	K232E	probably benign	Het
AI837181	C	T	19: 5,476,731 (GRCm39)	T298I	possibly damaging	Het
Alox12	T	C	11: 70,133,362 (GRCm39)	Y614C	probably damaging	Het
Amn	A	T	12: 111,240,575 (GRCm39)		probably null	Het
Ankrd33b	A	G	15: 31,305,272 (GRCm39)	S121P	probably benign	Het
Aox1	A	G	1: 58,131,675 (GRCm39)	Y1028C	probably damaging	Het
Asph	C	A	4: 9,453,314 (GRCm39)	R736L	probably benign	Het
Atp2a3	G	A	11: 72,861,757 (GRCm39)		probably null	Het
Cables2	T	C	2: 179,904,025 (GRCm39)		probably benign	Het
Catsperg2	A	T	7: 29,414,326 (GRCm39)	Y360N	possibly damaging	Het
Cdh4	T	C	2: 179,489,133 (GRCm39)	S282P	probably damaging	Het
Col5a3	C	T	9: 20,719,064 (GRCm39)		probably benign	Het
Ctso	A	T	3: 81,858,850 (GRCm39)		probably benign	Het
Cyp4f13	A	T	17: 33,151,625 (GRCm39)	Y125*	probably null	Het
Dapk1	T	A	13: 60,877,372 (GRCm39)	L537*	probably null	Het
Ddit4l	G	A	3: 137,331,946 (GRCm39)	R104Q	probably benign	Het
Def6	C	T	17: 28,442,909 (GRCm39)	H322Y	probably damaging	Het
Dnaaf9	A	T	2: 130,554,866 (GRCm39)		probably benign	Het
Dnah6	T	C	6: 73,165,342 (GRCm39)	N588D	probably benign	Het
Dzip1	T	A	14: 119,146,950 (GRCm39)	I320F	probably damaging	Het
Epb41l5	T	C	1: 119,536,934 (GRCm39)	H319R	probably damaging	Het
Erc2	A	G	14: 27,498,979 (GRCm39)	E285G	probably damaging	Het
Fat4	G	A	3: 38,945,376 (GRCm39)	G1423E	probably damaging	Het
Foxp2	C	T	6: 15,409,839 (GRCm39)	P480S	probably damaging	Het
Gadd45gip1	G	A	8: 85,560,762 (GRCm39)	A126T	probably damaging	Het
Gbp5	G	A	3: 142,211,172 (GRCm39)	D301N	probably benign	Het
Gm10360	T	C	6: 70,401,297 (GRCm39)		noncoding transcript	Het
Gm6471	T	A	7: 142,387,604 (GRCm39)		noncoding transcript	Het
H2bc18	A	C	3: 96,177,104 (GRCm39)	K13Q	probably null	Het
Ift172	A	G	5: 31,415,244 (GRCm39)	S1322P	possibly damaging	Het
Ift80	A	T	3: 68,821,986 (GRCm39)	Y686*	probably null	Het
Insrr	A	C	3: 87,715,953 (GRCm39)		probably null	Het
Itprid1	T	A	6: 55,945,019 (GRCm39)	M580K	probably benign	Het
Krt87	C	T	15: 101,384,900 (GRCm39)	V399M	probably benign	Het
Macf1	T	C	4: 123,351,776 (GRCm39)	N3708S	probably damaging	Het
Matcap1	A	T	8: 106,011,699 (GRCm39)	V222E	probably damaging	Het
Mogat1	T	C	1: 78,488,677 (GRCm39)	S27P	probably benign	Het
Mrgpra4	A	T	7: 47,631,574 (GRCm39)	M9K	probably benign	Het
Mtus1	A	T	8: 41,536,563 (GRCm39)	S384R	possibly damaging	Het
Myo1a	T	A	10: 127,546,771 (GRCm39)	M306K	probably benign	Het
Noxa1	G	T	2: 24,975,862 (GRCm39)	D403E	probably damaging	Het
Ogdhl	T	C	14: 32,068,415 (GRCm39)	V884A	possibly damaging	Het
Or10ak12	A	C	4: 118,666,614 (GRCm39)	L149R	probably damaging	Het
Or2y1f	A	G	11: 49,184,613 (GRCm39)	N155S	probably damaging	Het
Or6k4	T	A	1: 173,964,865 (GRCm39)	L185*	probably null	Het
Or6n1	T	C	1: 173,916,675 (GRCm39)	V23A	possibly damaging	Het
Paxip1	G	A	5: 27,963,621 (GRCm39)		probably benign	Het
Paxx	T	A	2: 25,350,079 (GRCm39)	E145D	probably damaging	Het
Pde4d	T	C	13: 110,087,802 (GRCm39)	V560A	possibly damaging	Het
Pheta2	C	T	15: 82,227,517 (GRCm39)	A12V	probably damaging	Het
Plxnd1	C	T	6: 115,946,421 (GRCm39)	V847M	probably benign	Het
Polk	T	A	13: 96,641,105 (GRCm39)	M151L	probably damaging	Het
Ptprq	C	T	10: 107,522,060 (GRCm39)		probably benign	Het
Pum2	A	G	12: 8,771,785 (GRCm39)	Q371R	possibly damaging	Het
Reln	G	A	5: 22,155,820 (GRCm39)	A2224V	probably damaging	Het
Rmc1	T	C	18: 12,312,266 (GRCm39)	S169P	possibly damaging	Het
Scart1	T	G	7: 139,807,808 (GRCm39)	C660G	probably damaging	Het
Shroom1	A	G	11: 53,356,035 (GRCm39)	T362A	probably damaging	Het
Smarcd2	A	G	11: 106,158,158 (GRCm39)		probably null	Het
Spg11	A	C	2: 121,896,713 (GRCm39)		probably benign	Het
Tcaf3	T	A	6: 42,566,761 (GRCm39)	Y776F	probably damaging	Het
Thada	A	G	17: 84,538,364 (GRCm39)	V1548A	probably damaging	Het
Trpv2	C	T	11: 62,481,130 (GRCm39)	P410S	probably damaging	Het
Ube2u	G	T	4: 100,338,851 (GRCm39)	E39*	probably null	Het
Ulbp3	A	T	10: 3,070,307 (GRCm39)		noncoding transcript	Het
Ulbp3	A	G	10: 3,075,788 (GRCm39)		noncoding transcript	Het
Vmn2r2	C	T	3: 64,041,320 (GRCm39)		probably null	Het
Vmn2r24	TCC	TC	6: 123,792,369 (GRCm39)		probably null	Het
Wdr87-ps	A	T	7: 29,235,007 (GRCm39)		noncoding transcript	Het
Zfp110	A	G	7: 12,570,302 (GRCm39)	Y43C	probably damaging	Het
Zfp605	A	G	5: 110,272,245 (GRCm39)	T55A	probably benign	Het

Other mutations in Gm8674

Allele	Source	Chr	Coord	Type	Predicted Effect
R0355:Gm8674	UTSW	13	50,055,975 (GRCm39)	exon	noncoding transcript
R0627:Gm8674	UTSW	13	50,053,751 (GRCm39)	exon	noncoding transcript
R0833:Gm8674	UTSW	13	50,058,611 (GRCm39)	exon	noncoding transcript
R1300:Gm8674	UTSW	13	50,055,758 (GRCm39)	exon	noncoding transcript
R1452:Gm8674	UTSW	13	50,054,553 (GRCm39)	exon	noncoding transcript
R1542:Gm8674	UTSW	13	50,054,039 (GRCm39)	exon	noncoding transcript
R1613:Gm8674	UTSW	13	50,056,474 (GRCm39)	intron	noncoding transcript
R1643:Gm8674	UTSW	13	50,055,394 (GRCm39)	exon	noncoding transcript
R1732:Gm8674	UTSW	13	50,055,962 (GRCm39)	exon	noncoding transcript
R1824:Gm8674	UTSW	13	50,054,844 (GRCm39)	exon	noncoding transcript
R1840:Gm8674	UTSW	13	50,055,801 (GRCm39)	exon	noncoding transcript
R1915:Gm8674	UTSW	13	50,054,889 (GRCm39)	exon	noncoding transcript
R1934:Gm8674	UTSW	13	50,055,471 (GRCm39)	exon	noncoding transcript
R2040:Gm8674	UTSW	13	50,055,705 (GRCm39)	exon	noncoding transcript
R2214:Gm8674	UTSW	13	50,055,396 (GRCm39)	exon	noncoding transcript
R2421:Gm8674	UTSW	13	50,054,699 (GRCm39)	exon	noncoding transcript
R3423:Gm8674	UTSW	13	50,055,792 (GRCm39)	exon	noncoding transcript
R3425:Gm8674	UTSW	13	50,055,792 (GRCm39)	exon	noncoding transcript
R3886:Gm8674	UTSW	13	50,056,199 (GRCm39)	splice site	noncoding transcript
R4083:Gm8674	UTSW	13	50,055,047 (GRCm39)	exon	noncoding transcript
R4343:Gm8674	UTSW	13	50,053,742 (GRCm39)	exon	noncoding transcript
R4570:Gm8674	UTSW	13	50,056,570 (GRCm39)	intron	noncoding transcript
R4936:Gm8674	UTSW	13	50,054,791 (GRCm39)	exon	noncoding transcript
R4967:Gm8674	UTSW	13	50,056,034 (GRCm39)	exon	noncoding transcript
R5065:Gm8674	UTSW	13	50,056,613 (GRCm39)	intron	noncoding transcript
R5067:Gm8674	UTSW	13	50,053,870 (GRCm39)	exon	noncoding transcript
R5120:Gm8674	UTSW	13	50,055,984 (GRCm39)	exon	noncoding transcript
R5208:Gm8674	UTSW	13	50,055,957 (GRCm39)	exon	noncoding transcript
R5268:Gm8674	UTSW	13	50,055,390 (GRCm39)	exon	noncoding transcript
R5471:Gm8674	UTSW	13	50,054,849 (GRCm39)	exon	noncoding transcript
R5773:Gm8674	UTSW	13	50,055,912 (GRCm39)	exon	noncoding transcript
R5809:Gm8674	UTSW	13	50,055,924 (GRCm39)	exon	noncoding transcript
R8162:Gm8674	UTSW	13	50,054,407 (GRCm39)	missense	noncoding transcript
R8239:Gm8674	UTSW	13	50,054,262 (GRCm39)	missense	noncoding transcript
Z1088:Gm8674	UTSW	13	50,055,284 (GRCm39)	exon	noncoding transcript
Z1088:Gm8674	UTSW	13	50,054,830 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- TCCCTCTCTCAATGGTAGGACATGC -3'
(R):5'- ACTGATCCTTTCTTGTGGCTGATGC -3'

Sequencing Primer
(F):5'- GTAGGACATGCTATTCCACAGGTC -3'
(R):5'- GGCTGATGCTTTTGCCTC -3'

Posted On

2013-04-24