Incidental Mutation 'IGL02572:Olfr806'
ID299024
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr806
Ensembl Gene ENSMUSG00000071065
Gene Nameolfactory receptor 806
SynonymsMOR110-5, MOR110-12, GA_x6K02T2PULF-11417610-11416669
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02572
Quality Score
Status
Chromosome10
Chromosomal Location129735571-129741921 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 129738866 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 17 (D17V)
Ref Sequence ENSEMBL: ENSMUSP00000150380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095245] [ENSMUST00000213239] [ENSMUST00000215142]
Predicted Effect possibly damaging
Transcript: ENSMUST00000095245
AA Change: D17V

PolyPhen 2 Score 0.811 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000092873
Gene: ENSMUSG00000071065
AA Change: D17V

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 2.6e-52 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204624
AA Change: D17V
SMART Domains Protein: ENSMUSP00000144955
Gene: ENSMUSG00000071065
AA Change: D17V

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 2.6e-52 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213239
AA Change: D17V

PolyPhen 2 Score 0.811 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215142
AA Change: D17V

PolyPhen 2 Score 0.811 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630001G21Rik T C 1: 85,725,171 N92S probably damaging Het
Abca2 T C 2: 25,433,317 L99P possibly damaging Het
Adam19 T A 11: 46,131,721 Y500* probably null Het
Amy1 A T 3: 113,565,073 probably benign Het
Aox3 T C 1: 58,158,367 I624T probably damaging Het
Atad3a C T 4: 155,753,584 D244N possibly damaging Het
Atp5j2 C A 5: 145,187,237 Het
Bbof1 G A 12: 84,428,365 D443N probably damaging Het
BC017158 A T 7: 128,290,580 probably benign Het
Bod1l G A 5: 41,821,230 Q914* probably null Het
C330011M18Rik A G 8: 84,066,579 probably benign Het
Cgref1 A G 5: 30,933,567 V301A probably benign Het
Coa6 T C 8: 126,422,741 Y19H probably damaging Het
Cop1 T A 1: 159,308,878 Het
Dmrta1 T C 4: 89,691,558 S252P probably benign Het
Dnaaf5 T G 5: 139,184,629 S484A probably benign Het
Dspp A T 5: 104,177,069 S433C probably damaging Het
Efcab5 G A 11: 77,137,888 R206* probably null Het
Epop A T 11: 97,628,201 S361T probably benign Het
Fat3 T A 9: 15,960,506 T3530S probably benign Het
Flvcr1 A G 1: 191,025,646 Y108H probably damaging Het
Fsip2 T G 2: 82,992,003 S6027A probably benign Het
Galnt14 A G 17: 73,535,267 L209P probably damaging Het
Hif3a C A 7: 17,050,588 R25L probably null Het
Hsf5 A G 11: 87,631,695 probably benign Het
Il22ra2 A T 10: 19,626,744 T104S probably benign Het
Klrk1 A G 6: 129,615,353 S138P probably damaging Het
Lrp5 G T 19: 3,614,283 Q815K probably benign Het
Morn4 A G 19: 42,076,447 probably benign Het
Nlrp14 T A 7: 107,182,722 Y375* probably null Het
Nsd1 T A 13: 55,296,130 M1714K probably damaging Het
Olfr171 T A 16: 19,625,098 M1L probably benign Het
Olfr259 G A 2: 87,108,366 T7I possibly damaging Het
Pappa2 C T 1: 158,851,216 A877T probably benign Het
Pcsk2 G A 2: 143,690,342 A137T probably damaging Het
Piezo1 A G 8: 122,485,305 V2054A probably benign Het
Rad52 A G 6: 119,915,227 Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Sbno1 A G 5: 124,381,677 Het
Scrn1 C T 6: 54,512,201 D312N probably benign Het
Sin3b A G 8: 72,744,481 Q352R probably benign Het
Slc25a28 A G 19: 43,664,446 Y259H probably damaging Het
Sppl2a T C 2: 126,926,296 M151V probably benign Het
Srrm1 G A 4: 135,325,104 Het
Stra8 G A 6: 34,939,159 D280N probably damaging Het
Thbs2 A T 17: 14,677,013 D744E possibly damaging Het
Tiparp A G 3: 65,531,889 T27A probably benign Het
Tmem38a T C 8: 72,579,974 F99S probably damaging Het
Tmod3 T C 9: 75,509,385 T222A probably benign Het
Tnn A G 1: 160,086,107 I1272T probably damaging Het
Tnpo1 A T 13: 98,849,159 I829N probably damaging Het
Trpm5 A T 7: 143,087,876 probably benign Het
Ttn A G 2: 76,767,871 V19566A probably damaging Het
V1ra8 A G 6: 90,203,058 D81G probably damaging Het
Zdhhc20 A G 14: 57,890,107 V25A probably benign Het
Other mutations in Olfr806
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01875:Olfr806 APN 10 129738922 utr 5 prime probably benign
IGL02090:Olfr806 APN 10 129738312 missense probably benign
IGL02328:Olfr806 APN 10 129738026 missense probably benign 0.35
R1773:Olfr806 UTSW 10 129738443 missense probably damaging 0.97
R1797:Olfr806 UTSW 10 129738709 missense probably benign 0.03
R4430:Olfr806 UTSW 10 129738261 missense probably damaging 1.00
R5704:Olfr806 UTSW 10 129738816 missense probably benign 0.00
R6140:Olfr806 UTSW 10 129738654 missense possibly damaging 0.95
R6655:Olfr806 UTSW 10 129738087 missense possibly damaging 0.96
R6858:Olfr806 UTSW 10 129738464 missense probably damaging 1.00
Posted On2015-04-16