Incidental Mutation 'IGL02576:Zdhhc25'
ID299190
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zdhhc25
Ensembl Gene ENSMUSG00000054117
Gene Namezinc finger, DHHC domain containing 25
Synonyms1700030J15Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #IGL02576
Quality Score
Status
Chromosome15
Chromosomal Location88600302-88601669 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 88601269 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 269 (H269L)
Ref Sequence ENSEMBL: ENSMUSP00000136289 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066949]
Predicted Effect probably benign
Transcript: ENSMUST00000066949
AA Change: H269L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000136289
Gene: ENSMUSG00000054117
AA Change: H269L

DomainStartEndE-ValueType
transmembrane domain 35 55 N/A INTRINSIC
transmembrane domain 65 87 N/A INTRINSIC
Pfam:zf-DHHC 105 235 2.4e-32 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,433,455 I232M probably benign Het
Ace G A 11: 105,974,111 V537M probably damaging Het
Alg1 A G 16: 5,244,529 E425G possibly damaging Het
Cacng3 G A 7: 122,671,910 S46N probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cfap65 A G 1: 74,903,458 S1646P probably damaging Het
Col20a1 C T 2: 181,013,405 Q1152* probably null Het
D130043K22Rik A C 13: 24,856,870 T92P possibly damaging Het
Drc3 T C 11: 60,370,551 M176T probably benign Het
Esyt3 T C 9: 99,315,225 R851G probably benign Het
Fbxo43 A G 15: 36,152,175 V496A probably benign Het
Fut4 T A 9: 14,751,405 M198L probably damaging Het
Galt C T 4: 41,755,953 probably benign Het
Glipr1l1 A G 10: 112,060,319 K4E possibly damaging Het
Gm9945 A G 11: 53,480,351 probably benign Het
Hspa12a A C 19: 58,799,410 I660R possibly damaging Het
Htr3b T C 9: 48,945,504 I225V possibly damaging Het
Igf2r T C 17: 12,748,763 D23G possibly damaging Het
Igsf5 A G 16: 96,386,581 I158V probably benign Het
Itgae A G 11: 73,118,505 Y505C possibly damaging Het
Kif16b A G 2: 142,862,545 probably benign Het
Kif26b T C 1: 178,916,347 V1336A probably benign Het
Kmt2d A G 15: 98,864,120 S450P unknown Het
Lexm T C 4: 106,591,628 D411G possibly damaging Het
Lhfpl2 G A 13: 94,174,226 M1I probably null Het
Lig4 A G 8: 9,971,116 I888T probably damaging Het
Msh4 G A 3: 153,867,746 T563M probably damaging Het
Muc5ac C T 7: 141,817,044 A3238V probably benign Het
Myo15b A G 11: 115,890,053 S1246G probably null Het
Olfr193 T C 16: 59,109,771 I280V probably benign Het
Pecam1 G A 11: 106,671,774 T599M probably damaging Het
Phf3 G A 1: 30,830,036 P644S probably benign Het
Pkd1l1 A C 11: 8,844,560 F2317C possibly damaging Het
Prdm4 A G 10: 85,900,937 M613T possibly damaging Het
Prim2 A T 1: 33,484,717 I371N probably damaging Het
Ptprs T C 17: 56,414,958 D1316G probably damaging Het
Rnf19b C T 4: 129,073,522 R285* probably null Het
Secisbp2 A G 13: 51,670,858 N381D possibly damaging Het
Slc28a2 T C 2: 122,458,171 I586T probably damaging Het
Spef1 T C 2: 131,174,642 H11R possibly damaging Het
Taar4 T C 10: 23,961,011 L173S probably damaging Het
Tas2r123 T C 6: 132,847,740 F200S possibly damaging Het
Tex16 T A X: 112,118,956 L384Q probably benign Het
Tox2 A G 2: 163,276,180 Q168R probably damaging Het
Trim5 T A 7: 104,278,417 E172V probably damaging Het
Txndc11 G A 16: 11,075,017 probably benign Het
Vmn1r232 T A 17: 20,913,913 I142F probably benign Het
Znrf4 T C 17: 56,512,199 D36G probably damaging Het
Other mutations in Zdhhc25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01999:Zdhhc25 APN 15 88601014 missense probably damaging 0.98
IGL02448:Zdhhc25 APN 15 88600842 missense probably damaging 1.00
R0001:Zdhhc25 UTSW 15 88600909 missense probably benign 0.00
R0394:Zdhhc25 UTSW 15 88600920 missense probably damaging 0.96
R0622:Zdhhc25 UTSW 15 88601107 missense probably damaging 0.98
R1116:Zdhhc25 UTSW 15 88600620 missense probably benign 0.25
R1132:Zdhhc25 UTSW 15 88600723 missense probably damaging 1.00
R1854:Zdhhc25 UTSW 15 88600486 missense probably benign
R1994:Zdhhc25 UTSW 15 88600824 missense probably benign 0.00
R2102:Zdhhc25 UTSW 15 88600759 missense probably benign 0.10
R3749:Zdhhc25 UTSW 15 88601023 missense probably benign 0.00
R5144:Zdhhc25 UTSW 15 88601056 missense probably damaging 0.98
R5220:Zdhhc25 UTSW 15 88601162 nonsense probably null
Posted On2015-04-16