Incidental Mutation 'IGL02577:Mrgpra4'
| ID |
299226 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrgpra4
|
| Ensembl Gene |
ENSMUSG00000067173 |
| Gene Name |
MAS-related GPR, member A4 |
| Synonyms |
MrgA4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
IGL02577
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
47630585-47631843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 47630981 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 207
(T207S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084327
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087092]
|
| AlphaFold |
Q91WW2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087092
AA Change: T207S
PolyPhen 2
Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000084327
Gene: ENSMUSG00000067173
AA Change: T207S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
38 |
270 |
1.3e-10 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 17 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acmsd |
T |
C |
1: 127,667,696 (GRCm39) |
I40T |
probably benign |
Het |
| Adgrg3 |
C |
T |
8: 95,766,555 (GRCm39) |
R409C |
probably damaging |
Het |
| Cpa5 |
G |
T |
6: 30,626,807 (GRCm39) |
|
probably benign |
Het |
| Idi2l |
C |
A |
13: 8,993,288 (GRCm39) |
Q68H |
probably damaging |
Het |
| Ippk |
G |
A |
13: 49,615,134 (GRCm39) |
V506I |
possibly damaging |
Het |
| Lcn2 |
A |
G |
2: 32,277,101 (GRCm39) |
Y158H |
probably damaging |
Het |
| Mon1b |
G |
T |
8: 114,365,455 (GRCm39) |
R261L |
possibly damaging |
Het |
| Or1e30 |
T |
C |
11: 73,677,872 (GRCm39) |
L36P |
probably damaging |
Het |
| Pip5k1c |
C |
A |
10: 81,153,155 (GRCm39) |
|
probably null |
Het |
| Poln |
T |
A |
5: 34,270,679 (GRCm39) |
M451L |
probably benign |
Het |
| Rrh |
A |
C |
3: 129,609,372 (GRCm39) |
V45G |
probably damaging |
Het |
| Smg1 |
A |
T |
7: 117,802,345 (GRCm39) |
M251K |
probably damaging |
Het |
| Tdrd6 |
T |
A |
17: 43,937,728 (GRCm39) |
I1107F |
probably damaging |
Het |
| Tgm5 |
T |
C |
2: 120,908,084 (GRCm39) |
I31V |
probably benign |
Het |
| Vps36 |
C |
T |
8: 22,701,632 (GRCm39) |
Q240* |
probably null |
Het |
| Wdr6 |
C |
T |
9: 108,453,140 (GRCm39) |
V248I |
possibly damaging |
Het |
| Zfp143 |
A |
G |
7: 109,691,114 (GRCm39) |
E555G |
probably damaging |
Het |
|
| Other mutations in Mrgpra4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00790:Mrgpra4
|
APN |
7 |
47,631,052 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02083:Mrgpra4
|
APN |
7 |
47,630,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02155:Mrgpra4
|
APN |
7 |
47,631,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02674:Mrgpra4
|
APN |
7 |
47,630,690 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02696:Mrgpra4
|
APN |
7 |
47,631,251 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0357:Mrgpra4
|
UTSW |
7 |
47,631,574 (GRCm39) |
missense |
probably benign |
|
|
R0543:Mrgpra4
|
UTSW |
7 |
47,631,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0677:Mrgpra4
|
UTSW |
7 |
47,630,728 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1163:Mrgpra4
|
UTSW |
7 |
47,631,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1217:Mrgpra4
|
UTSW |
7 |
47,631,085 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2255:Mrgpra4
|
UTSW |
7 |
47,631,523 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4191:Mrgpra4
|
UTSW |
7 |
47,630,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4303:Mrgpra4
|
UTSW |
7 |
47,630,684 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4472:Mrgpra4
|
UTSW |
7 |
47,631,539 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4757:Mrgpra4
|
UTSW |
7 |
47,630,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Mrgpra4
|
UTSW |
7 |
47,631,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Mrgpra4
|
UTSW |
7 |
47,631,535 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5034:Mrgpra4
|
UTSW |
7 |
47,631,317 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5119:Mrgpra4
|
UTSW |
7 |
47,631,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Mrgpra4
|
UTSW |
7 |
47,630,755 (GRCm39) |
missense |
probably benign |
|
|
R6800:Mrgpra4
|
UTSW |
7 |
47,631,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Mrgpra4
|
UTSW |
7 |
47,631,238 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7585:Mrgpra4
|
UTSW |
7 |
47,631,377 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7636:Mrgpra4
|
UTSW |
7 |
47,630,721 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8162:Mrgpra4
|
UTSW |
7 |
47,631,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8352:Mrgpra4
|
UTSW |
7 |
47,631,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8452:Mrgpra4
|
UTSW |
7 |
47,631,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8812:Mrgpra4
|
UTSW |
7 |
47,631,481 (GRCm39) |
missense |
probably benign |
|
|
R8996:Mrgpra4
|
UTSW |
7 |
47,630,945 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9026:Mrgpra4
|
UTSW |
7 |
47,631,208 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
X0028:Mrgpra4
|
UTSW |
7 |
47,631,168 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation