Incidental Mutation 'IGL02580:Cyp2c37'
| ID |
299311 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cyp2c37
|
| Ensembl Gene |
ENSMUSG00000042248 |
| Gene Name |
cytochrome P450, family 2. subfamily c, polypeptide 37 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.107)
|
| Stock # |
IGL02580
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
39980868-40000687 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 39982942 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 177
(V177D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000045362
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049178]
|
| AlphaFold |
P56654 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000049178
AA Change: V177D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: V177D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:p450
|
30 |
487 |
5e-160 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp3 |
A |
T |
9: 104,204,147 (GRCm39) |
I49N |
probably damaging |
Het |
| Aqp8 |
T |
C |
7: 123,065,953 (GRCm39) |
|
probably benign |
Het |
| Atrnl1 |
T |
C |
19: 57,703,008 (GRCm39) |
|
probably benign |
Het |
| Cdh1 |
A |
G |
8: 107,375,650 (GRCm39) |
T63A |
probably benign |
Het |
| Cenpf |
A |
G |
1: 189,389,638 (GRCm39) |
L1398S |
probably benign |
Het |
| Ctdp1 |
T |
A |
18: 80,493,305 (GRCm39) |
S397C |
probably benign |
Het |
| Elmo3 |
A |
T |
8: 106,035,126 (GRCm39) |
D419V |
probably damaging |
Het |
| Fabp1 |
T |
C |
6: 71,180,128 (GRCm39) |
S100P |
probably damaging |
Het |
| Hcfc2 |
A |
T |
10: 82,564,256 (GRCm39) |
N485I |
probably benign |
Het |
| Igkv10-95 |
A |
G |
6: 68,657,636 (GRCm39) |
T51A |
probably benign |
Het |
| Iqub |
A |
G |
6: 24,501,398 (GRCm39) |
I184T |
probably benign |
Het |
| Map2k6 |
G |
A |
11: 110,381,667 (GRCm39) |
R71H |
probably damaging |
Het |
| Mon1b |
G |
T |
8: 114,365,455 (GRCm39) |
R261L |
possibly damaging |
Het |
| Ncapg2 |
T |
C |
12: 116,384,309 (GRCm39) |
S257P |
probably damaging |
Het |
| Nusap1 |
T |
C |
2: 119,479,371 (GRCm39) |
|
probably benign |
Het |
| Nwd2 |
A |
G |
5: 63,965,512 (GRCm39) |
R1699G |
probably damaging |
Het |
| Olfm3 |
A |
G |
3: 114,916,157 (GRCm39) |
N363S |
probably damaging |
Het |
| Or51g1 |
C |
T |
7: 102,633,909 (GRCm39) |
S154N |
probably damaging |
Het |
| Or9m2 |
T |
C |
2: 87,820,857 (GRCm39) |
V134A |
probably benign |
Het |
| Pirb |
T |
C |
7: 3,717,205 (GRCm39) |
|
probably null |
Het |
| Plch2 |
G |
A |
4: 155,069,221 (GRCm39) |
T1135I |
probably benign |
Het |
| Riox2 |
G |
A |
16: 59,306,936 (GRCm39) |
V276I |
probably benign |
Het |
| Slc11a1 |
A |
G |
1: 74,419,418 (GRCm39) |
D144G |
probably damaging |
Het |
| Usp40 |
C |
A |
1: 87,908,688 (GRCm39) |
|
probably null |
Het |
| Vars2 |
G |
A |
17: 35,971,777 (GRCm39) |
A73V |
possibly damaging |
Het |
|
| Other mutations in Cyp2c37 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00465:Cyp2c37
|
APN |
19 |
39,990,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01307:Cyp2c37
|
APN |
19 |
39,981,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01959:Cyp2c37
|
APN |
19 |
39,984,277 (GRCm39) |
nonsense |
probably null |
|
|
IGL02611:Cyp2c37
|
APN |
19 |
39,982,309 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0124:Cyp2c37
|
UTSW |
19 |
39,982,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0391:Cyp2c37
|
UTSW |
19 |
39,982,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0420:Cyp2c37
|
UTSW |
19 |
39,984,238 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0782:Cyp2c37
|
UTSW |
19 |
39,982,269 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1413:Cyp2c37
|
UTSW |
19 |
39,982,542 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1637:Cyp2c37
|
UTSW |
19 |
39,990,426 (GRCm39) |
nonsense |
probably null |
|
|
R1688:Cyp2c37
|
UTSW |
19 |
39,982,887 (GRCm39) |
splice site |
probably null |
|
|
R2258:Cyp2c37
|
UTSW |
19 |
39,984,303 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4353:Cyp2c37
|
UTSW |
19 |
39,988,989 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4640:Cyp2c37
|
UTSW |
19 |
40,000,276 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4965:Cyp2c37
|
UTSW |
19 |
40,000,206 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5053:Cyp2c37
|
UTSW |
19 |
39,990,331 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5645:Cyp2c37
|
UTSW |
19 |
39,982,596 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5847:Cyp2c37
|
UTSW |
19 |
40,000,176 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6487:Cyp2c37
|
UTSW |
19 |
39,983,025 (GRCm39) |
missense |
probably benign |
|
|
R6631:Cyp2c37
|
UTSW |
19 |
39,998,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7062:Cyp2c37
|
UTSW |
19 |
39,983,990 (GRCm39) |
splice site |
probably null |
|
|
R7937:Cyp2c37
|
UTSW |
19 |
39,982,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Cyp2c37
|
UTSW |
19 |
40,000,180 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9779:Cyp2c37
|
UTSW |
19 |
39,998,323 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9784:Cyp2c37
|
UTSW |
19 |
39,988,943 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
| Posted On |
2015-04-16 |
Incidental Mutation