Incidental Mutation 'IGL02580:Plch2'
ID 299316
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Plch2
Ensembl Gene ENSMUSG00000029055
Gene Name phospholipase C, eta 2
Synonyms PLCeta2, Plcl4, A930027K05Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02580
Quality Score
Status
Chromosome 4
Chromosomal Location 155067572-155141241 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 155069221 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 1135 (T1135I)
Ref Sequence ENSEMBL: ENSMUSP00000101256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030931] [ENSMUST00000070953] [ENSMUST00000105631] [ENSMUST00000135665] [ENSMUST00000186598] [ENSMUST00000139976] [ENSMUST00000176194]
AlphaFold A2AP18
Predicted Effect probably benign
Transcript: ENSMUST00000030931
SMART Domains Protein: ENSMUSP00000030931
Gene: ENSMUSG00000029056

DomainStartEndE-ValueType
low complexity region 5 15 N/A INTRINSIC
Pfam:Fumble 35 369 1.5e-142 PFAM
low complexity region 415 428 N/A INTRINSIC
Pfam:DUF89 451 763 1.4e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000070953
SMART Domains Protein: ENSMUSP00000064330
Gene: ENSMUSG00000029056

DomainStartEndE-ValueType
low complexity region 5 15 N/A INTRINSIC
Pfam:Fumble 36 367 1.8e-133 PFAM
low complexity region 415 428 N/A INTRINSIC
Pfam:DUF89 451 810 3.1e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105631
AA Change: T1135I

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000101256
Gene: ENSMUSG00000029055
AA Change: T1135I

DomainStartEndE-ValueType
low complexity region 28 45 N/A INTRINSIC
low complexity region 96 107 N/A INTRINSIC
PH 122 231 1.8e-6 SMART
EFh 247 275 7.29e-4 SMART
EFh 283 312 4.67e-2 SMART
Pfam:EF-hand_like 317 399 1.7e-26 PFAM
PLCXc 400 545 6.76e-76 SMART
low complexity region 559 572 N/A INTRINSIC
low complexity region 659 676 N/A INTRINSIC
PLCYc 707 821 1.25e-56 SMART
C2 840 948 1.66e-21 SMART
low complexity region 1088 1107 N/A INTRINSIC
low complexity region 1227 1236 N/A INTRINSIC
low complexity region 1356 1369 N/A INTRINSIC
low complexity region 1421 1451 N/A INTRINSIC
low complexity region 1454 1466 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105632
Predicted Effect probably benign
Transcript: ENSMUST00000124517
SMART Domains Protein: ENSMUSP00000122139
Gene: ENSMUSG00000029055

DomainStartEndE-ValueType
C2 1 77 1.58e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127661
Predicted Effect probably benign
Transcript: ENSMUST00000135665
AA Change: T1030I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000118292
Gene: ENSMUSG00000029055
AA Change: T1030I

DomainStartEndE-ValueType
PH 17 126 1.8e-6 SMART
EFh 142 170 7.29e-4 SMART
EFh 178 207 4.67e-2 SMART
Pfam:EF-hand_like 212 294 2.8e-25 PFAM
PLCXc 295 440 6.76e-76 SMART
low complexity region 454 467 N/A INTRINSIC
low complexity region 554 571 N/A INTRINSIC
PLCYc 602 716 1.25e-56 SMART
C2 735 843 1.66e-21 SMART
low complexity region 983 1002 N/A INTRINSIC
low complexity region 1122 1131 N/A INTRINSIC
low complexity region 1251 1264 N/A INTRINSIC
low complexity region 1316 1346 N/A INTRINSIC
low complexity region 1349 1361 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000175982
AA Change: T883I
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176620
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129386
Predicted Effect probably benign
Transcript: ENSMUST00000186598
SMART Domains Protein: ENSMUSP00000141152
Gene: ENSMUSG00000029055

DomainStartEndE-ValueType
C2 79 189 5.8e-18 SMART
low complexity region 328 341 N/A INTRINSIC
low complexity region 407 435 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139976
SMART Domains Protein: ENSMUSP00000122704
Gene: ENSMUSG00000029055

DomainStartEndE-ValueType
low complexity region 28 45 N/A INTRINSIC
low complexity region 96 107 N/A INTRINSIC
PH 122 231 1.8e-6 SMART
EFh 247 275 7.29e-4 SMART
EFh 283 312 4.67e-2 SMART
Pfam:EF-hand_like 317 399 3.2e-27 PFAM
PLCXc 400 545 6.76e-76 SMART
low complexity region 559 572 N/A INTRINSIC
low complexity region 659 676 N/A INTRINSIC
PLCYc 707 821 1.25e-56 SMART
C2 840 948 1.66e-21 SMART
low complexity region 1087 1100 N/A INTRINSIC
low complexity region 1166 1194 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148934
SMART Domains Protein: ENSMUSP00000125663
Gene: ENSMUSG00000029056

DomainStartEndE-ValueType
Pfam:Fumble 1 225 2.6e-103 PFAM
low complexity region 273 286 N/A INTRINSIC
Pfam:DUF89 309 472 1.9e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176194
SMART Domains Protein: ENSMUSP00000134750
Gene: ENSMUSG00000029055

DomainStartEndE-ValueType
PH 21 130 1.8e-6 SMART
EFh 146 174 7.29e-4 SMART
EFh 182 211 4.67e-2 SMART
Pfam:EF-hand_like 216 298 1.6e-25 PFAM
PLCXc 299 444 6.76e-76 SMART
low complexity region 458 471 N/A INTRINSIC
low complexity region 558 575 N/A INTRINSIC
PLCYc 606 720 1.25e-56 SMART
C2 739 847 1.66e-21 SMART
low complexity region 986 999 N/A INTRINSIC
low complexity region 1065 1093 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
PHENOTYPE: Mice homozygous for a reporter allele exhibit no apparent abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 A T 9: 104,204,147 (GRCm39) I49N probably damaging Het
Aqp8 T C 7: 123,065,953 (GRCm39) probably benign Het
Atrnl1 T C 19: 57,703,008 (GRCm39) probably benign Het
Cdh1 A G 8: 107,375,650 (GRCm39) T63A probably benign Het
Cenpf A G 1: 189,389,638 (GRCm39) L1398S probably benign Het
Ctdp1 T A 18: 80,493,305 (GRCm39) S397C probably benign Het
Cyp2c37 T A 19: 39,982,942 (GRCm39) V177D probably damaging Het
Elmo3 A T 8: 106,035,126 (GRCm39) D419V probably damaging Het
Fabp1 T C 6: 71,180,128 (GRCm39) S100P probably damaging Het
Hcfc2 A T 10: 82,564,256 (GRCm39) N485I probably benign Het
Igkv10-95 A G 6: 68,657,636 (GRCm39) T51A probably benign Het
Iqub A G 6: 24,501,398 (GRCm39) I184T probably benign Het
Map2k6 G A 11: 110,381,667 (GRCm39) R71H probably damaging Het
Mon1b G T 8: 114,365,455 (GRCm39) R261L possibly damaging Het
Ncapg2 T C 12: 116,384,309 (GRCm39) S257P probably damaging Het
Nusap1 T C 2: 119,479,371 (GRCm39) probably benign Het
Nwd2 A G 5: 63,965,512 (GRCm39) R1699G probably damaging Het
Olfm3 A G 3: 114,916,157 (GRCm39) N363S probably damaging Het
Or51g1 C T 7: 102,633,909 (GRCm39) S154N probably damaging Het
Or9m2 T C 2: 87,820,857 (GRCm39) V134A probably benign Het
Pirb T C 7: 3,717,205 (GRCm39) probably null Het
Riox2 G A 16: 59,306,936 (GRCm39) V276I probably benign Het
Slc11a1 A G 1: 74,419,418 (GRCm39) D144G probably damaging Het
Usp40 C A 1: 87,908,688 (GRCm39) probably null Het
Vars2 G A 17: 35,971,777 (GRCm39) A73V possibly damaging Het
Other mutations in Plch2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Plch2 APN 4 155,091,099 (GRCm39) missense probably damaging 1.00
IGL02024:Plch2 APN 4 155,127,595 (GRCm39) intron probably benign
IGL03370:Plch2 APN 4 155,071,371 (GRCm39) missense probably benign 0.18
IGL03407:Plch2 APN 4 155,074,255 (GRCm39) missense probably damaging 1.00
tolerant UTSW 4 155,069,092 (GRCm39) missense probably benign 0.01
PIT4418001:Plch2 UTSW 4 155,073,960 (GRCm39) missense probably damaging 1.00
PIT4445001:Plch2 UTSW 4 155,093,483 (GRCm39) missense probably damaging 1.00
R0117:Plch2 UTSW 4 155,069,815 (GRCm39) unclassified probably benign
R0347:Plch2 UTSW 4 155,071,178 (GRCm39) missense possibly damaging 0.91
R0361:Plch2 UTSW 4 155,091,168 (GRCm39) missense possibly damaging 0.95
R0413:Plch2 UTSW 4 155,091,373 (GRCm39) critical splice donor site probably null
R0487:Plch2 UTSW 4 155,093,469 (GRCm39) missense probably damaging 1.00
R0514:Plch2 UTSW 4 155,083,343 (GRCm39) missense probably damaging 1.00
R0734:Plch2 UTSW 4 155,080,740 (GRCm39) missense probably damaging 1.00
R0766:Plch2 UTSW 4 155,074,256 (GRCm39) missense probably damaging 1.00
R1306:Plch2 UTSW 4 155,091,597 (GRCm39) missense probably damaging 1.00
R1312:Plch2 UTSW 4 155,074,256 (GRCm39) missense probably damaging 1.00
R1467:Plch2 UTSW 4 155,068,189 (GRCm39) missense probably benign 0.02
R1467:Plch2 UTSW 4 155,068,189 (GRCm39) missense probably benign 0.02
R1602:Plch2 UTSW 4 155,068,907 (GRCm39) missense probably damaging 0.99
R1717:Plch2 UTSW 4 155,082,729 (GRCm39) missense probably benign
R1731:Plch2 UTSW 4 155,091,451 (GRCm39) missense possibly damaging 0.83
R1769:Plch2 UTSW 4 155,084,540 (GRCm39) missense probably damaging 1.00
R1875:Plch2 UTSW 4 155,082,965 (GRCm39) missense probably damaging 1.00
R1974:Plch2 UTSW 4 155,069,410 (GRCm39) missense possibly damaging 0.77
R2031:Plch2 UTSW 4 155,127,484 (GRCm39) intron probably benign
R2050:Plch2 UTSW 4 155,085,275 (GRCm39) missense probably benign 0.00
R2061:Plch2 UTSW 4 155,127,298 (GRCm39) intron probably benign
R2073:Plch2 UTSW 4 155,074,366 (GRCm39) missense probably damaging 1.00
R2075:Plch2 UTSW 4 155,074,366 (GRCm39) missense probably damaging 1.00
R2109:Plch2 UTSW 4 155,069,054 (GRCm39) missense possibly damaging 0.92
R2126:Plch2 UTSW 4 155,083,456 (GRCm39) missense probably damaging 1.00
R2265:Plch2 UTSW 4 155,077,461 (GRCm39) missense probably benign 0.06
R2266:Plch2 UTSW 4 155,077,461 (GRCm39) missense probably benign 0.06
R2269:Plch2 UTSW 4 155,077,461 (GRCm39) missense probably benign 0.06
R2280:Plch2 UTSW 4 155,068,766 (GRCm39) missense probably damaging 1.00
R2281:Plch2 UTSW 4 155,068,766 (GRCm39) missense probably damaging 1.00
R2432:Plch2 UTSW 4 155,070,621 (GRCm39) makesense probably null
R2971:Plch2 UTSW 4 155,075,224 (GRCm39) missense probably benign 0.29
R3437:Plch2 UTSW 4 155,075,470 (GRCm39) critical splice donor site probably null
R3980:Plch2 UTSW 4 155,069,255 (GRCm39) missense probably benign 0.00
R4757:Plch2 UTSW 4 155,080,690 (GRCm39) missense possibly damaging 0.88
R4827:Plch2 UTSW 4 155,075,570 (GRCm39) missense probably damaging 1.00
R4828:Plch2 UTSW 4 155,069,092 (GRCm39) missense probably benign 0.01
R4869:Plch2 UTSW 4 155,073,885 (GRCm39) missense probably benign 0.28
R5020:Plch2 UTSW 4 155,091,540 (GRCm39) missense probably damaging 1.00
R5050:Plch2 UTSW 4 155,127,766 (GRCm39) intron probably benign
R5126:Plch2 UTSW 4 155,084,976 (GRCm39) missense probably damaging 1.00
R5237:Plch2 UTSW 4 155,095,251 (GRCm39) missense probably benign
R5274:Plch2 UTSW 4 155,083,411 (GRCm39) missense probably damaging 1.00
R5296:Plch2 UTSW 4 155,074,456 (GRCm39) splice site probably null
R5324:Plch2 UTSW 4 155,068,991 (GRCm39) missense probably benign
R5475:Plch2 UTSW 4 155,084,594 (GRCm39) missense probably damaging 1.00
R5494:Plch2 UTSW 4 155,075,579 (GRCm39) missense probably damaging 1.00
R5811:Plch2 UTSW 4 155,077,024 (GRCm39) missense possibly damaging 0.62
R6083:Plch2 UTSW 4 155,085,275 (GRCm39) missense probably benign 0.00
R6092:Plch2 UTSW 4 155,068,829 (GRCm39) missense probably benign 0.02
R6253:Plch2 UTSW 4 155,091,558 (GRCm39) missense probably damaging 1.00
R6456:Plch2 UTSW 4 155,077,459 (GRCm39) missense probably damaging 1.00
R7038:Plch2 UTSW 4 155,074,489 (GRCm39) splice site probably null
R7084:Plch2 UTSW 4 155,071,448 (GRCm39) missense probably benign 0.31
R7210:Plch2 UTSW 4 155,093,543 (GRCm39) missense probably damaging 1.00
R7216:Plch2 UTSW 4 155,068,685 (GRCm39) missense probably benign
R7264:Plch2 UTSW 4 155,083,424 (GRCm39) missense probably damaging 0.98
R7291:Plch2 UTSW 4 155,082,929 (GRCm39) missense probably damaging 1.00
R7423:Plch2 UTSW 4 155,068,194 (GRCm39) missense probably damaging 1.00
R7436:Plch2 UTSW 4 155,068,553 (GRCm39) missense probably benign 0.01
R7438:Plch2 UTSW 4 155,084,917 (GRCm39) missense probably damaging 1.00
R7594:Plch2 UTSW 4 155,091,484 (GRCm39) missense probably damaging 1.00
R7663:Plch2 UTSW 4 155,075,619 (GRCm39) missense probably damaging 0.96
R7698:Plch2 UTSW 4 155,087,244 (GRCm39) missense possibly damaging 0.95
R7844:Plch2 UTSW 4 155,073,922 (GRCm39) missense probably damaging 1.00
R7939:Plch2 UTSW 4 155,087,235 (GRCm39) missense possibly damaging 0.91
R8003:Plch2 UTSW 4 155,138,980 (GRCm39) missense unknown
R8007:Plch2 UTSW 4 155,087,288 (GRCm39) missense probably damaging 1.00
R8281:Plch2 UTSW 4 155,091,430 (GRCm39) missense probably benign 0.07
R8434:Plch2 UTSW 4 155,074,192 (GRCm39) missense probably damaging 1.00
R8504:Plch2 UTSW 4 155,068,852 (GRCm39) missense probably benign 0.31
R8516:Plch2 UTSW 4 155,070,764 (GRCm39) missense probably benign
R8558:Plch2 UTSW 4 155,083,391 (GRCm39) missense probably damaging 1.00
R8722:Plch2 UTSW 4 155,069,860 (GRCm39) unclassified probably benign
R8768:Plch2 UTSW 4 155,083,324 (GRCm39) missense probably damaging 1.00
R8787:Plch2 UTSW 4 155,070,875 (GRCm39) missense probably benign 0.00
R8826:Plch2 UTSW 4 155,071,140 (GRCm39) missense probably benign 0.00
R8955:Plch2 UTSW 4 155,077,023 (GRCm39) missense probably benign 0.00
R9032:Plch2 UTSW 4 155,084,976 (GRCm39) missense probably damaging 1.00
R9085:Plch2 UTSW 4 155,084,976 (GRCm39) missense probably damaging 1.00
R9423:Plch2 UTSW 4 155,071,049 (GRCm39) missense
R9649:Plch2 UTSW 4 155,068,516 (GRCm39) missense probably benign
R9652:Plch2 UTSW 4 155,082,942 (GRCm39) missense probably benign
R9725:Plch2 UTSW 4 155,084,992 (GRCm39) missense probably damaging 1.00
R9742:Plch2 UTSW 4 155,082,912 (GRCm39) missense probably damaging 0.99
R9789:Plch2 UTSW 4 155,095,322 (GRCm39) critical splice donor site probably null
RF014:Plch2 UTSW 4 155,091,577 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16