Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02580:Iqub'

299331

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iqub

Ensembl Gene

ENSMUSG00000046192

Gene Name

IQ motif and ubiquitin domain containing

Synonyms

4932408B21Rik, Trs4

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02580

Quality Score

Status

Chromosome

Chromosomal Location

24444864-24515066 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 24501398 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 184 (I184T)

Ref Sequence

ENSEMBL: ENSMUSP00000051177 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052277]

AlphaFold

Q8CDK3

Predicted Effect

probably benign
Transcript: ENSMUST00000052277
AA Change: I184T

PolyPhen 2 Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000051177
Gene: ENSMUSG00000046192
AA Change: I184T

Domain	Start	End	E-Value	Type
PDB:2DAF\|A	119	216	1e-38	PDB
Blast:UBQ	129	199	3e-26	BLAST
low complexity region	218	229	N/A	INTRINSIC
low complexity region	289	306	N/A	INTRINSIC
IQ	333	355	1.74e-1	SMART
low complexity region	357	383	N/A	INTRINSIC
low complexity region	735	742	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(2) : Targeted, knock-out(2)

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp3	A	T	9: 104,204,147 (GRCm39)	I49N	probably damaging	Het
Aqp8	T	C	7: 123,065,953 (GRCm39)		probably benign	Het
Atrnl1	T	C	19: 57,703,008 (GRCm39)		probably benign	Het
Cdh1	A	G	8: 107,375,650 (GRCm39)	T63A	probably benign	Het
Cenpf	A	G	1: 189,389,638 (GRCm39)	L1398S	probably benign	Het
Ctdp1	T	A	18: 80,493,305 (GRCm39)	S397C	probably benign	Het
Cyp2c37	T	A	19: 39,982,942 (GRCm39)	V177D	probably damaging	Het
Elmo3	A	T	8: 106,035,126 (GRCm39)	D419V	probably damaging	Het
Fabp1	T	C	6: 71,180,128 (GRCm39)	S100P	probably damaging	Het
Hcfc2	A	T	10: 82,564,256 (GRCm39)	N485I	probably benign	Het
Igkv10-95	A	G	6: 68,657,636 (GRCm39)	T51A	probably benign	Het
Map2k6	G	A	11: 110,381,667 (GRCm39)	R71H	probably damaging	Het
Mon1b	G	T	8: 114,365,455 (GRCm39)	R261L	possibly damaging	Het
Ncapg2	T	C	12: 116,384,309 (GRCm39)	S257P	probably damaging	Het
Nusap1	T	C	2: 119,479,371 (GRCm39)		probably benign	Het
Nwd2	A	G	5: 63,965,512 (GRCm39)	R1699G	probably damaging	Het
Olfm3	A	G	3: 114,916,157 (GRCm39)	N363S	probably damaging	Het
Or51g1	C	T	7: 102,633,909 (GRCm39)	S154N	probably damaging	Het
Or9m2	T	C	2: 87,820,857 (GRCm39)	V134A	probably benign	Het
Pirb	T	C	7: 3,717,205 (GRCm39)		probably null	Het
Plch2	G	A	4: 155,069,221 (GRCm39)	T1135I	probably benign	Het
Riox2	G	A	16: 59,306,936 (GRCm39)	V276I	probably benign	Het
Slc11a1	A	G	1: 74,419,418 (GRCm39)	D144G	probably damaging	Het
Usp40	C	A	1: 87,908,688 (GRCm39)		probably null	Het
Vars2	G	A	17: 35,971,777 (GRCm39)	A73V	possibly damaging	Het

Other mutations in Iqub

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01015:Iqub	APN	6	24,501,005 (GRCm39)	splice site	probably benign
IGL01447:Iqub	APN	6	24,505,627 (GRCm39)	missense	probably benign	0.01
IGL01621:Iqub	APN	6	24,446,211 (GRCm39)	missense	probably benign	0.45
IGL01702:Iqub	APN	6	24,500,312 (GRCm39)	missense	probably benign	0.13
IGL01917:Iqub	APN	6	24,479,318 (GRCm39)	missense	probably damaging	0.97
IGL02411:Iqub	APN	6	24,449,810 (GRCm39)	missense	probably damaging	0.98
IGL02704:Iqub	APN	6	24,505,909 (GRCm39)	splice site	probably benign
IGL02901:Iqub	APN	6	24,454,194 (GRCm39)	missense	probably damaging	1.00
D4043:Iqub	UTSW	6	24,505,750 (GRCm39)	missense	possibly damaging	0.81
R0304:Iqub	UTSW	6	24,454,290 (GRCm39)	missense	probably damaging	0.99
R0391:Iqub	UTSW	6	24,446,154 (GRCm39)	missense	probably benign	0.00
R0453:Iqub	UTSW	6	24,450,829 (GRCm39)	missense	probably damaging	1.00
R0464:Iqub	UTSW	6	24,479,262 (GRCm39)	nonsense	probably null
R0465:Iqub	UTSW	6	24,503,783 (GRCm39)	missense	probably damaging	1.00
R0479:Iqub	UTSW	6	24,505,809 (GRCm39)	missense	probably benign	0.28
R0606:Iqub	UTSW	6	24,501,260 (GRCm39)	splice site	probably benign
R1146:Iqub	UTSW	6	24,505,627 (GRCm39)	missense	possibly damaging	0.89
R1146:Iqub	UTSW	6	24,505,627 (GRCm39)	missense	possibly damaging	0.89
R1238:Iqub	UTSW	6	24,505,884 (GRCm39)	missense	probably benign	0.03
R1452:Iqub	UTSW	6	24,491,558 (GRCm39)	missense	probably benign	0.13
R1927:Iqub	UTSW	6	24,491,670 (GRCm39)	missense	probably benign	0.11
R3195:Iqub	UTSW	6	24,462,036 (GRCm39)	splice site	probably benign
R4438:Iqub	UTSW	6	24,505,867 (GRCm39)	missense	probably benign	0.01
R4577:Iqub	UTSW	6	24,501,290 (GRCm39)	missense	probably damaging	0.99
R4671:Iqub	UTSW	6	24,479,183 (GRCm39)	missense	probably benign	0.00
R4860:Iqub	UTSW	6	24,450,841 (GRCm39)	missense	probably damaging	0.99
R4860:Iqub	UTSW	6	24,450,841 (GRCm39)	missense	probably damaging	0.99
R4906:Iqub	UTSW	6	24,501,368 (GRCm39)	missense	probably damaging	0.99
R5605:Iqub	UTSW	6	24,505,620 (GRCm39)	missense	probably benign
R5772:Iqub	UTSW	6	24,454,250 (GRCm39)	missense	possibly damaging	0.64
R5801:Iqub	UTSW	6	24,449,768 (GRCm39)	missense	probably benign	0.11
R5853:Iqub	UTSW	6	24,491,601 (GRCm39)	missense	probably benign	0.00
R6423:Iqub	UTSW	6	24,491,528 (GRCm39)	missense	probably damaging	0.98
R6475:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6476:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6477:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6701:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6702:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6703:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6860:Iqub	UTSW	6	24,505,737 (GRCm39)	missense	possibly damaging	0.81
R7331:Iqub	UTSW	6	24,500,393 (GRCm39)	missense	possibly damaging	0.73
R7530:Iqub	UTSW	6	24,450,622 (GRCm39)	missense	probably benign	0.00
R7997:Iqub	UTSW	6	24,501,413 (GRCm39)	missense	possibly damaging	0.86
R8050:Iqub	UTSW	6	24,503,784 (GRCm39)	missense	possibly damaging	0.95
R8141:Iqub	UTSW	6	24,491,608 (GRCm39)	missense	probably benign	0.00
R8153:Iqub	UTSW	6	24,450,789 (GRCm39)	nonsense	probably null
R8163:Iqub	UTSW	6	24,449,714 (GRCm39)	missense	probably benign	0.01
R8702:Iqub	UTSW	6	24,461,914 (GRCm39)	missense	probably damaging	1.00
R8824:Iqub	UTSW	6	24,479,307 (GRCm39)	nonsense	probably null
R8899:Iqub	UTSW	6	24,505,768 (GRCm39)	missense	probably benign	0.00
R9075:Iqub	UTSW	6	24,446,124 (GRCm39)	missense	probably damaging	1.00
R9186:Iqub	UTSW	6	24,450,766 (GRCm39)	missense	possibly damaging	0.92
R9240:Iqub	UTSW	6	24,505,622 (GRCm39)	missense	probably benign
R9256:Iqub	UTSW	6	24,446,198 (GRCm39)	missense	possibly damaging	0.92
X0025:Iqub	UTSW	6	24,500,383 (GRCm39)	missense	probably damaging	0.96
Z1088:Iqub	UTSW	6	24,500,242 (GRCm39)	splice site	probably null

Posted On

2015-04-16