Incidental Mutation 'IGL02584:Mzf1'
ID 299461
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mzf1
Ensembl Gene ENSMUSG00000030380
Gene Name myeloid zinc finger 1
Synonyms Zfp98, Zfp121, Znf42, Mzf2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # IGL02584
Quality Score
Status
Chromosome 7
Chromosomal Location 12776230-12788691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12786744 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 109 (W109R)
Ref Sequence ENSEMBL: ENSMUSP00000138387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069289] [ENSMUST00000182087] [ENSMUST00000182490] [ENSMUST00000182515]
AlphaFold S4R1L6
Predicted Effect probably damaging
Transcript: ENSMUST00000069289
AA Change: W109R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000069122
Gene: ENSMUSG00000030380
AA Change: W109R

DomainStartEndE-ValueType
low complexity region 24 34 N/A INTRINSIC
SCAN 41 153 1.18e-70 SMART
ZnF_C2H2 357 379 4.87e-4 SMART
ZnF_C2H2 385 407 1.95e-3 SMART
ZnF_C2H2 413 435 1.18e-2 SMART
ZnF_C2H2 441 463 8.6e-5 SMART
ZnF_C2H2 486 508 1.79e-2 SMART
ZnF_C2H2 514 536 7.15e-2 SMART
ZnF_C2H2 542 564 8.47e-4 SMART
ZnF_C2H2 570 592 2.79e-4 SMART
ZnF_C2H2 598 620 1.6e-4 SMART
ZnF_C2H2 626 648 1.67e-2 SMART
ZnF_C2H2 654 676 3.44e-4 SMART
ZnF_C2H2 682 704 2.84e-5 SMART
ZnF_C2H2 710 732 2.4e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000182087
AA Change: W109R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000138163
Gene: ENSMUSG00000030380
AA Change: W109R

DomainStartEndE-ValueType
low complexity region 24 34 N/A INTRINSIC
SCAN 41 152 9.06e-58 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182293
Predicted Effect probably benign
Transcript: ENSMUST00000182490
AA Change: W188R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000138271
Gene: ENSMUSG00000030380
AA Change: W188R

DomainStartEndE-ValueType
low complexity region 103 113 N/A INTRINSIC
SCAN 120 232 1.18e-70 SMART
ZnF_C2H2 436 458 4.87e-4 SMART
ZnF_C2H2 464 486 1.95e-3 SMART
ZnF_C2H2 492 514 1.18e-2 SMART
ZnF_C2H2 520 542 8.6e-5 SMART
ZnF_C2H2 565 587 1.79e-2 SMART
ZnF_C2H2 593 615 7.15e-2 SMART
ZnF_C2H2 621 643 8.47e-4 SMART
ZnF_C2H2 649 671 2.79e-4 SMART
ZnF_C2H2 677 699 1.6e-4 SMART
ZnF_C2H2 705 727 1.67e-2 SMART
ZnF_C2H2 733 755 3.44e-4 SMART
ZnF_C2H2 761 783 2.84e-5 SMART
ZnF_C2H2 789 811 2.4e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000182515
AA Change: W109R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000138387
Gene: ENSMUSG00000030380
AA Change: W109R

DomainStartEndE-ValueType
low complexity region 24 34 N/A INTRINSIC
SCAN 41 153 1.18e-70 SMART
ZnF_C2H2 357 379 4.87e-4 SMART
ZnF_C2H2 385 407 1.95e-3 SMART
ZnF_C2H2 413 435 1.18e-2 SMART
ZnF_C2H2 441 463 8.6e-5 SMART
ZnF_C2H2 486 508 1.79e-2 SMART
ZnF_C2H2 514 536 7.15e-2 SMART
ZnF_C2H2 542 564 8.47e-4 SMART
ZnF_C2H2 570 592 2.79e-4 SMART
ZnF_C2H2 598 620 1.6e-4 SMART
ZnF_C2H2 626 648 1.67e-2 SMART
ZnF_C2H2 654 676 3.44e-4 SMART
ZnF_C2H2 682 704 2.84e-5 SMART
ZnF_C2H2 710 732 2.4e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183176
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210727
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutants are prone to late-onset (>2 yr) neoplasias characterized by infiltration, enlargement and disruption of the liver by monomorphic cells of myeloid origin; hemopoietic progenitors show increased ability to sustain long-term hemopoiesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110057P08Rik A T 16: 88,971,744 (GRCm39) Y22F unknown Het
Adgrb3 A G 1: 25,544,065 (GRCm39) L312P probably damaging Het
Anpep T C 7: 79,475,141 (GRCm39) probably benign Het
Arhgef6 T G X: 56,291,738 (GRCm39) probably benign Het
Catsperg1 T C 7: 28,884,146 (GRCm39) D989G probably damaging Het
Ccnj T A 19: 40,833,185 (GRCm39) V121E probably benign Het
Cdyl T C 13: 35,867,769 (GRCm39) L15P probably benign Het
Cnrip1 T A 11: 17,028,536 (GRCm39) M156K probably damaging Het
Cryga T A 1: 65,142,175 (GRCm39) S73C probably benign Het
Dennd4a A G 9: 64,758,580 (GRCm39) T240A probably damaging Het
Eml6 A G 11: 29,699,387 (GRCm39) S1789P probably damaging Het
Esr2 A T 12: 76,192,036 (GRCm39) W331R probably damaging Het
Fbh1 A T 2: 11,764,769 (GRCm39) L455H probably benign Het
Gm21698 T A 5: 26,192,391 (GRCm39) E65V probably damaging Het
Grm8 G T 6: 27,762,438 (GRCm39) F262L probably benign Het
Haus3 A T 5: 34,323,602 (GRCm39) L336* probably null Het
Hfm1 A C 5: 107,026,528 (GRCm39) probably null Het
Hgfac T C 5: 35,201,305 (GRCm39) probably benign Het
Ighv1-22 T C 12: 114,709,942 (GRCm39) E101G probably benign Het
Impg2 A G 16: 56,085,374 (GRCm39) E1027G probably damaging Het
Lypd5 A T 7: 24,052,993 (GRCm39) T217S possibly damaging Het
Myrf A G 19: 10,189,587 (GRCm39) probably benign Het
Ndufb4 A T 16: 37,469,532 (GRCm39) probably benign Het
Ntn1 A G 11: 68,168,356 (GRCm39) V367A probably damaging Het
Oprk1 A G 1: 5,668,827 (GRCm39) K91R probably damaging Het
Or5m11b C T 2: 85,806,219 (GRCm39) L211F probably damaging Het
Pdlim1 A G 19: 40,231,844 (GRCm39) probably null Het
Ppp1r11 G A 17: 37,260,781 (GRCm39) R61C probably damaging Het
Racgap1 T C 15: 99,521,515 (GRCm39) D547G probably benign Het
Sema4b A G 7: 79,874,736 (GRCm39) T709A probably benign Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Supt5 T C 7: 28,025,592 (GRCm39) H218R probably benign Het
Tmem132c T A 5: 127,582,063 (GRCm39) I426N probably damaging Het
Tpcn1 T C 5: 120,677,097 (GRCm39) N696S probably damaging Het
Ttn T C 2: 76,566,506 (GRCm39) N26383S possibly damaging Het
Vax2 A G 6: 83,688,495 (GRCm39) T73A probably benign Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Other mutations in Mzf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Mzf1 APN 7 12,778,543 (GRCm39) missense possibly damaging 0.85
IGL01728:Mzf1 APN 7 12,785,654 (GRCm39) splice site probably benign
IGL02194:Mzf1 APN 7 12,777,647 (GRCm39) missense possibly damaging 0.53
IGL02256:Mzf1 APN 7 12,786,664 (GRCm39) splice site probably benign
IGL02678:Mzf1 APN 7 12,786,836 (GRCm39) missense probably benign 0.00
R0903:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R0904:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R0905:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R1128:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R1131:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R1280:Mzf1 UTSW 7 12,787,010 (GRCm39) missense probably damaging 0.96
R1400:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R1640:Mzf1 UTSW 7 12,777,197 (GRCm39) makesense probably null
R1687:Mzf1 UTSW 7 12,786,698 (GRCm39) missense possibly damaging 0.82
R4014:Mzf1 UTSW 7 12,777,883 (GRCm39) missense possibly damaging 0.47
R4721:Mzf1 UTSW 7 12,777,448 (GRCm39) missense possibly damaging 0.53
R4721:Mzf1 UTSW 7 12,777,223 (GRCm39) missense possibly damaging 0.52
R5511:Mzf1 UTSW 7 12,785,526 (GRCm39) missense possibly damaging 0.95
R5611:Mzf1 UTSW 7 12,778,554 (GRCm39) utr 3 prime probably benign
R5728:Mzf1 UTSW 7 12,777,985 (GRCm39) missense probably benign 0.00
R5868:Mzf1 UTSW 7 12,787,116 (GRCm39) missense probably benign 0.00
R6283:Mzf1 UTSW 7 12,787,296 (GRCm39) intron probably benign
R7059:Mzf1 UTSW 7 12,786,985 (GRCm39) missense probably damaging 0.96
R7066:Mzf1 UTSW 7 12,777,490 (GRCm39) missense possibly damaging 0.92
R7763:Mzf1 UTSW 7 12,778,018 (GRCm39) missense probably damaging 1.00
R8157:Mzf1 UTSW 7 12,778,279 (GRCm39) missense probably damaging 1.00
R8870:Mzf1 UTSW 7 12,786,836 (GRCm39) missense probably benign 0.00
R9063:Mzf1 UTSW 7 12,787,005 (GRCm39) missense probably damaging 1.00
R9113:Mzf1 UTSW 7 12,778,279 (GRCm39) missense probably damaging 1.00
R9252:Mzf1 UTSW 7 12,777,647 (GRCm39) missense probably benign 0.33
R9289:Mzf1 UTSW 7 12,785,534 (GRCm39) missense probably benign 0.02
R9792:Mzf1 UTSW 7 12,786,131 (GRCm39) missense probably benign 0.02
Posted On 2015-04-16