Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02584:Lypd5'

299479

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lypd5

Ensembl Gene

ENSMUSG00000030484

Gene Name

Ly6/Plaur domain containing 5

Synonyms

2210003I03Rik, 2310011E23Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02584

Quality Score

Status

Chromosome

Chromosomal Location

24048621-24053672 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 24052993 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 217 (T217S)

Ref Sequence

ENSEMBL: ENSMUSP00000032683 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032683]

AlphaFold

Q9D7Z7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000032683
AA Change: T217S

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000032683
Gene: ENSMUSG00000030484
AA Change: T217S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Blast:LU	24	119	7e-38	BLAST
LU	132	225	1.19e-1	SMART
low complexity region	230	248	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110057P08Rik	A	T	16: 88,971,744 (GRCm39)	Y22F	unknown	Het
Adgrb3	A	G	1: 25,544,065 (GRCm39)	L312P	probably damaging	Het
Anpep	T	C	7: 79,475,141 (GRCm39)		probably benign	Het
Arhgef6	T	G	X: 56,291,738 (GRCm39)		probably benign	Het
Catsperg1	T	C	7: 28,884,146 (GRCm39)	D989G	probably damaging	Het
Ccnj	T	A	19: 40,833,185 (GRCm39)	V121E	probably benign	Het
Cdyl	T	C	13: 35,867,769 (GRCm39)	L15P	probably benign	Het
Cnrip1	T	A	11: 17,028,536 (GRCm39)	M156K	probably damaging	Het
Cryga	T	A	1: 65,142,175 (GRCm39)	S73C	probably benign	Het
Dennd4a	A	G	9: 64,758,580 (GRCm39)	T240A	probably damaging	Het
Eml6	A	G	11: 29,699,387 (GRCm39)	S1789P	probably damaging	Het
Esr2	A	T	12: 76,192,036 (GRCm39)	W331R	probably damaging	Het
Fbh1	A	T	2: 11,764,769 (GRCm39)	L455H	probably benign	Het
Gm21698	T	A	5: 26,192,391 (GRCm39)	E65V	probably damaging	Het
Grm8	G	T	6: 27,762,438 (GRCm39)	F262L	probably benign	Het
Haus3	A	T	5: 34,323,602 (GRCm39)	L336*	probably null	Het
Hfm1	A	C	5: 107,026,528 (GRCm39)		probably null	Het
Hgfac	T	C	5: 35,201,305 (GRCm39)		probably benign	Het
Ighv1-22	T	C	12: 114,709,942 (GRCm39)	E101G	probably benign	Het
Impg2	A	G	16: 56,085,374 (GRCm39)	E1027G	probably damaging	Het
Myrf	A	G	19: 10,189,587 (GRCm39)		probably benign	Het
Mzf1	A	G	7: 12,786,744 (GRCm39)	W109R	probably damaging	Het
Ndufb4	A	T	16: 37,469,532 (GRCm39)		probably benign	Het
Ntn1	A	G	11: 68,168,356 (GRCm39)	V367A	probably damaging	Het
Oprk1	A	G	1: 5,668,827 (GRCm39)	K91R	probably damaging	Het
Or5m11b	C	T	2: 85,806,219 (GRCm39)	L211F	probably damaging	Het
Pdlim1	A	G	19: 40,231,844 (GRCm39)		probably null	Het
Ppp1r11	G	A	17: 37,260,781 (GRCm39)	R61C	probably damaging	Het
Racgap1	T	C	15: 99,521,515 (GRCm39)	D547G	probably benign	Het
Sema4b	A	G	7: 79,874,736 (GRCm39)	T709A	probably benign	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Supt5	T	C	7: 28,025,592 (GRCm39)	H218R	probably benign	Het
Tmem132c	T	A	5: 127,582,063 (GRCm39)	I426N	probably damaging	Het
Tpcn1	T	C	5: 120,677,097 (GRCm39)	N696S	probably damaging	Het
Ttn	T	C	2: 76,566,506 (GRCm39)	N26383S	possibly damaging	Het
Vax2	A	G	6: 83,688,495 (GRCm39)	T73A	probably benign	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het

Other mutations in Lypd5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01066:Lypd5	APN	7	24,052,910 (GRCm39)	missense	probably benign	0.10
IGL01121:Lypd5	APN	7	24,050,976 (GRCm39)	missense	probably benign
IGL01689:Lypd5	APN	7	24,052,054 (GRCm39)	splice site	probably benign
IGL02888:Lypd5	APN	7	24,052,044 (GRCm39)	missense	probably damaging	0.98
R5167:Lypd5	UTSW	7	24,051,889 (GRCm39)	missense	possibly damaging	0.79
R5982:Lypd5	UTSW	7	24,052,462 (GRCm39)	missense	probably damaging	1.00
R6746:Lypd5	UTSW	7	24,052,531 (GRCm39)	splice site	probably null
R7951:Lypd5	UTSW	7	24,051,060 (GRCm39)	missense	probably damaging	0.96
R8704:Lypd5	UTSW	7	24,050,982 (GRCm39)	missense	possibly damaging	0.62
R8725:Lypd5	UTSW	7	24,053,101 (GRCm39)	missense	probably damaging	1.00
R8727:Lypd5	UTSW	7	24,053,101 (GRCm39)	missense	probably damaging	1.00
R8897:Lypd5	UTSW	7	24,051,015 (GRCm39)	missense	probably benign	0.13
X0057:Lypd5	UTSW	7	24,048,646 (GRCm39)	utr 5 prime	probably benign
Z1177:Lypd5	UTSW	7	24,052,038 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16