Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02590:Ncoa7'

299704

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ncoa7

Ensembl Gene

ENSMUSG00000039697

Gene Name

nuclear receptor coactivator 7

Synonyms

9030406N13Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02590

Quality Score

Status

Chromosome

Chromosomal Location

30521578-30683401 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 30570159 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 267 (E267K)

Ref Sequence

ENSEMBL: ENSMUSP00000149335 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068567] [ENSMUST00000213836] [ENSMUST00000215725] [ENSMUST00000215740] [ENSMUST00000215926]

AlphaFold

Q6DFV7

Predicted Effect

probably damaging
Transcript: ENSMUST00000068567
AA Change: E267K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000066741
Gene: ENSMUSG00000039697
AA Change: E267K

Domain	Start	End	E-Value	Type
coiled coil region	1	32	N/A	INTRINSIC
LysM	118	161	2.24e-7	SMART
low complexity region	165	176	N/A	INTRINSIC
TLDc	781	943	2.86e-64	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000213836
AA Change: E267K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000215725

Predicted Effect

probably damaging
Transcript: ENSMUST00000215740
AA Change: E267K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000215926
AA Change: E229K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably benign
Transcript: ENSMUST00000217398

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(108) : Gene trapped(108)

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl3	A	G	4: 144,184,404 (GRCm39)	F118S	probably damaging	Het
Adam5	T	G	8: 25,234,151 (GRCm39)		probably benign	Het
Bok	T	C	1: 93,614,397 (GRCm39)		probably benign	Het
C1s1	C	T	6: 124,508,235 (GRCm39)	V585I	possibly damaging	Het
Chd2	C	T	7: 73,102,948 (GRCm39)	V1346I	probably benign	Het
Cyb5a	A	T	18: 84,889,732 (GRCm39)	T54S	probably benign	Het
Dnah7b	A	T	1: 46,162,937 (GRCm39)	T428S	probably benign	Het
Efhc1	T	C	1: 21,037,608 (GRCm39)	Y262H	probably damaging	Het
Fyb2	A	T	4: 104,836,250 (GRCm39)	I404F	probably damaging	Het
Glra2	T	C	X: 164,037,222 (GRCm39)	N237S	probably benign	Het
Gypc	A	G	18: 32,663,060 (GRCm39)	*96R	probably null	Het
Il15	T	C	8: 83,069,912 (GRCm39)	I51V	probably benign	Het
Itgb2	T	C	10: 77,395,347 (GRCm39)	C483R	probably damaging	Het
Kdr	C	T	5: 76,096,983 (GRCm39)	D1272N	probably benign	Het
Kif14	C	A	1: 136,423,742 (GRCm39)	T969K	probably benign	Het
Klhl42	T	C	6: 146,993,810 (GRCm39)	S261P	probably damaging	Het
Lrp1	C	A	10: 127,388,660 (GRCm39)	G3263V	probably damaging	Het
Mid1	A	G	X: 168,710,019 (GRCm39)	E5G	probably damaging	Het
Mmrn2	T	A	14: 34,121,224 (GRCm39)	L698*	probably null	Het
Myh14	T	G	7: 44,273,503 (GRCm39)	Q1393P	probably damaging	Het
Obox5	T	C	7: 15,491,517 (GRCm39)	I19T	possibly damaging	Het
Or13a20	A	G	7: 140,232,305 (GRCm39)		probably null	Het
Or8k22	A	G	2: 86,163,344 (GRCm39)	S119P	possibly damaging	Het
Pcnx1	A	G	12: 82,041,752 (GRCm39)	Y2128C	probably damaging	Het
Plcb1	A	G	2: 135,136,784 (GRCm39)	D293G	probably benign	Het
Prpf4b	T	C	13: 35,072,129 (GRCm39)		probably benign	Het
Psapl1	A	T	5: 36,362,397 (GRCm39)	T330S	probably benign	Het
Rap1gap	A	G	4: 137,447,611 (GRCm39)	T453A	probably damaging	Het
Ric1	T	A	19: 29,544,881 (GRCm39)		probably benign	Het
Robo1	A	G	16: 72,840,020 (GRCm39)	E1590G	probably benign	Het
Sorl1	C	T	9: 41,957,857 (GRCm39)	V596I	probably benign	Het
Tlr12	A	G	4: 128,511,182 (GRCm39)	I356T	probably benign	Het
Trav8d-2	T	C	14: 53,279,906 (GRCm39)	S8P	possibly damaging	Het
Tyms	C	A	5: 30,269,149 (GRCm39)	V75L	probably benign	Het
Vmn1r230	T	A	17: 21,067,172 (GRCm39)	S120R	probably damaging	Het
Vmn2r84	T	A	10: 130,227,356 (GRCm39)		probably benign	Het
Wdr27	C	T	17: 15,138,041 (GRCm39)	A388T	possibly damaging	Het

Other mutations in Ncoa7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01406:Ncoa7	APN	10	30,566,836 (GRCm39)	missense	probably damaging	1.00
IGL01716:Ncoa7	APN	10	30,538,330 (GRCm39)	missense	probably damaging	0.96
IGL02114:Ncoa7	APN	10	30,538,360 (GRCm39)	missense	probably damaging	1.00
IGL02170:Ncoa7	APN	10	30,565,849 (GRCm39)	missense	possibly damaging	0.94
IGL02436:Ncoa7	APN	10	30,570,143 (GRCm39)	missense	probably damaging	1.00
IGL02499:Ncoa7	APN	10	30,566,885 (GRCm39)	missense	probably benign	0.04
IGL02533:Ncoa7	APN	10	30,598,781 (GRCm39)	missense	probably damaging	1.00
IGL02533:Ncoa7	APN	10	30,566,895 (GRCm39)	missense	possibly damaging	0.87
IGL02657:Ncoa7	APN	10	30,528,972 (GRCm39)	missense	probably damaging	1.00
IGL03065:Ncoa7	APN	10	30,523,993 (GRCm39)	missense	probably damaging	1.00
IGL03088:Ncoa7	APN	10	30,574,121 (GRCm39)	splice site	probably null
IGL03090:Ncoa7	APN	10	30,538,396 (GRCm39)	missense	probably damaging	0.96
IGL03196:Ncoa7	APN	10	30,523,510 (GRCm39)	utr 3 prime	probably benign
D6062:Ncoa7	UTSW	10	30,598,651 (GRCm39)	missense	probably damaging	1.00
R0058:Ncoa7	UTSW	10	30,523,537 (GRCm39)	missense	probably damaging	1.00
R0058:Ncoa7	UTSW	10	30,523,537 (GRCm39)	missense	probably damaging	1.00
R0578:Ncoa7	UTSW	10	30,577,913 (GRCm39)	critical splice donor site	probably null
R0729:Ncoa7	UTSW	10	30,567,575 (GRCm39)	missense	probably benign	0.00
R1538:Ncoa7	UTSW	10	30,570,207 (GRCm39)	missense	probably damaging	0.99
R1539:Ncoa7	UTSW	10	30,647,725 (GRCm39)	missense	probably damaging	1.00
R1574:Ncoa7	UTSW	10	30,570,097 (GRCm39)	missense	probably damaging	1.00
R1574:Ncoa7	UTSW	10	30,570,097 (GRCm39)	missense	probably damaging	1.00
R1624:Ncoa7	UTSW	10	30,580,655 (GRCm39)	missense	possibly damaging	0.87
R1639:Ncoa7	UTSW	10	30,577,988 (GRCm39)	missense	probably damaging	1.00
R1655:Ncoa7	UTSW	10	30,574,241 (GRCm39)	critical splice acceptor site	probably null
R1876:Ncoa7	UTSW	10	30,574,122 (GRCm39)	intron	probably benign
R1885:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1886:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1887:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1909:Ncoa7	UTSW	10	30,565,796 (GRCm39)	missense	probably damaging	1.00
R1938:Ncoa7	UTSW	10	30,574,166 (GRCm39)	missense	probably benign	0.02
R1965:Ncoa7	UTSW	10	30,530,426 (GRCm39)	nonsense	probably null
R1978:Ncoa7	UTSW	10	30,567,295 (GRCm39)	missense	probably benign
R2303:Ncoa7	UTSW	10	30,530,431 (GRCm39)	missense	probably damaging	1.00
R3777:Ncoa7	UTSW	10	30,565,752 (GRCm39)	missense	probably damaging	1.00
R3778:Ncoa7	UTSW	10	30,565,752 (GRCm39)	missense	probably damaging	1.00
R4026:Ncoa7	UTSW	10	30,598,720 (GRCm39)	missense	probably benign	0.02
R4230:Ncoa7	UTSW	10	30,574,253 (GRCm39)	splice site	probably null
R4667:Ncoa7	UTSW	10	30,566,786 (GRCm39)	missense	probably damaging	1.00
R4786:Ncoa7	UTSW	10	30,531,638 (GRCm39)	missense	probably benign	0.28
R4809:Ncoa7	UTSW	10	30,647,758 (GRCm39)	missense	possibly damaging	0.92
R4820:Ncoa7	UTSW	10	30,524,472 (GRCm39)	missense	probably damaging	1.00
R4839:Ncoa7	UTSW	10	30,598,655 (GRCm39)	missense	possibly damaging	0.93
R4861:Ncoa7	UTSW	10	30,580,608 (GRCm39)	missense	probably benign
R4861:Ncoa7	UTSW	10	30,580,608 (GRCm39)	missense	probably benign
R5271:Ncoa7	UTSW	10	30,598,725 (GRCm39)	missense	probably benign	0.02
R5384:Ncoa7	UTSW	10	30,598,813 (GRCm39)	missense	probably benign	0.00
R5418:Ncoa7	UTSW	10	30,524,035 (GRCm39)	missense	probably damaging	1.00
R5964:Ncoa7	UTSW	10	30,580,632 (GRCm39)	missense	probably damaging	1.00
R6257:Ncoa7	UTSW	10	30,570,173 (GRCm39)	missense	probably damaging	1.00
R6683:Ncoa7	UTSW	10	30,647,717 (GRCm39)	missense	probably damaging	0.99
R6813:Ncoa7	UTSW	10	30,572,188 (GRCm39)	missense	probably damaging	1.00
R6910:Ncoa7	UTSW	10	30,570,117 (GRCm39)	missense	possibly damaging	0.89
R7123:Ncoa7	UTSW	10	30,530,435 (GRCm39)	missense	probably benign	0.28
R7327:Ncoa7	UTSW	10	30,565,796 (GRCm39)	missense	probably damaging	1.00
R7412:Ncoa7	UTSW	10	30,598,847 (GRCm39)	missense	possibly damaging	0.94
R7638:Ncoa7	UTSW	10	30,598,794 (GRCm39)	missense	probably benign	0.35
R7653:Ncoa7	UTSW	10	30,570,239 (GRCm39)	missense	probably damaging	1.00
R7848:Ncoa7	UTSW	10	30,524,414 (GRCm39)	missense	possibly damaging	0.82
R7861:Ncoa7	UTSW	10	30,567,056 (GRCm39)	missense	probably benign	0.38
R8125:Ncoa7	UTSW	10	30,570,087 (GRCm39)	missense	possibly damaging	0.80
R8198:Ncoa7	UTSW	10	30,580,664 (GRCm39)	missense	probably benign	0.00
R8240:Ncoa7	UTSW	10	30,567,725 (GRCm39)	missense	probably benign	0.45
R8353:Ncoa7	UTSW	10	30,570,155 (GRCm39)	missense	probably damaging	1.00
R8509:Ncoa7	UTSW	10	30,572,048 (GRCm39)	missense	probably benign	0.00
R8861:Ncoa7	UTSW	10	30,567,364 (GRCm39)	missense	probably benign	0.02
R9040:Ncoa7	UTSW	10	30,530,389 (GRCm39)	missense	probably benign	0.00
R9136:Ncoa7	UTSW	10	30,567,628 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16