Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02596:Zfp770'

299856

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp770

Ensembl Gene

ENSMUSG00000040321

Gene Name

zinc finger protein 770

Synonyms

6430601A21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.233) question?

Stock #

IGL02596

Quality Score

Status

Chromosome

Chromosomal Location

114023937-114031945 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 114026308 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 587 (V587A)

Ref Sequence

ENSEMBL: ENSMUSP00000052194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050668]

AlphaFold

Q8BIQ8

Predicted Effect

probably benign
Transcript: ENSMUST00000050668
AA Change: V587A

PolyPhen 2 Score 0.109 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000052194
Gene: ENSMUSG00000040321
AA Change: V587A

Domain	Start	End	E-Value	Type
ZnF_C2H2	31	53	1.18e-2	SMART
ZnF_C2H2	59	81	4.11e-2	SMART
ZnF_C2H2	85	107	3.58e-2	SMART
ZnF_C2H2	164	186	2.09e-3	SMART
ZnF_C2H2	192	214	3.58e-2	SMART
ZnF_C2H2	220	242	3.29e-1	SMART
ZnF_C2H2	298	318	1.93e2	SMART
low complexity region	341	354	N/A	INTRINSIC
ZnF_C2H2	485	507	5.9e-3	SMART
ZnF_C2H2	513	535	1.82e-3	SMART
low complexity region	576	595	N/A	INTRINSIC
ZnF_C2H2	640	662	9.58e-3	SMART
ZnF_C2H2	668	690	7.37e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123562

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310002L09Rik	T	G	4: 73,868,904 (GRCm39)	Q11H	possibly damaging	Het
Armcx5	T	A	X: 134,647,268 (GRCm39)	I448K	probably damaging	Het
Atp4b	T	A	8: 13,443,471 (GRCm39)	Y69F	possibly damaging	Het
Ccdc7b	T	A	8: 129,798,959 (GRCm39)	V12E	probably benign	Het
Cdc5l	C	A	17: 45,735,530 (GRCm39)		probably benign	Het
Clptm1l	C	T	13: 73,761,785 (GRCm39)	R330C	probably benign	Het
Cpq	C	T	15: 33,213,160 (GRCm39)	R60W	probably damaging	Het
Cpvl	T	C	6: 53,908,995 (GRCm39)	Y256C	probably damaging	Het
Cryzl2	A	T	1: 157,292,539 (GRCm39)	D107V	probably damaging	Het
Cyp2e1	G	A	7: 140,350,031 (GRCm39)	V239M	probably damaging	Het
Cyp2j7	T	A	4: 96,103,659 (GRCm39)	D292V	possibly damaging	Het
Dcaf1	A	G	9: 106,740,220 (GRCm39)	Y1202C	probably damaging	Het
Dnah3	T	C	7: 119,538,137 (GRCm39)	N3616S	probably benign	Het
Enam	A	G	5: 88,650,885 (GRCm39)	D723G	probably benign	Het
Eps8l1	G	A	7: 4,473,871 (GRCm39)	R226H	probably damaging	Het
Erich2	A	G	2: 70,343,147 (GRCm39)		probably benign	Het
Esyt3	A	C	9: 99,210,068 (GRCm39)	L271V	probably benign	Het
Fer1l4	T	C	2: 155,881,052 (GRCm39)	N838S	probably benign	Het
Gad1	T	C	2: 70,425,028 (GRCm39)	Y441H	probably damaging	Het
Gja1	G	T	10: 56,264,348 (GRCm39)	V236F	possibly damaging	Het
Gpr156	T	C	16: 37,799,086 (GRCm39)	I100T	probably benign	Het
Hace1	A	G	10: 45,576,736 (GRCm39)	T803A	possibly damaging	Het
Jagn1	G	A	6: 113,424,562 (GRCm39)	V145I	probably benign	Het
Kdm4b	C	A	17: 56,706,706 (GRCm39)	T899K	probably benign	Het
Klk1b8	G	A	7: 43,602,187 (GRCm39)	V40M	probably damaging	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Mast1	G	T	8: 85,644,400 (GRCm39)	A843E	probably benign	Het
Mbd1	T	A	18: 74,409,868 (GRCm39)		probably benign	Het
Mdga1	A	G	17: 30,051,379 (GRCm39)		probably benign	Het
Mlh3	A	G	12: 85,287,732 (GRCm39)		probably null	Het
Or10ag53	C	A	2: 87,082,473 (GRCm39)	T64K	probably damaging	Het
Or5b109	A	T	19: 13,211,763 (GRCm39)	I50F	probably damaging	Het
Pwp1	A	G	10: 85,707,882 (GRCm39)		probably null	Het
Rbm12	C	T	2: 155,937,480 (GRCm39)		probably benign	Het
Slc12a7	T	A	13: 73,933,242 (GRCm39)	V100E	probably benign	Het
Spata31e2	T	A	1: 26,723,083 (GRCm39)	H699L	probably benign	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tgfb1i1	T	A	7: 127,848,068 (GRCm39)	M1K	probably null	Het
Tubgcp6	T	A	15: 88,985,117 (GRCm39)	E1657V	probably damaging	Het
Zxdc	A	G	6: 90,350,691 (GRCm39)		probably null	Het

Other mutations in Zfp770

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Zfp770	APN	2	114,026,413 (GRCm39)	missense	probably benign	0.20
IGL00478:Zfp770	APN	2	114,027,946 (GRCm39)	missense	probably damaging	1.00
IGL01539:Zfp770	APN	2	114,027,574 (GRCm39)	missense	probably damaging	0.99
IGL01778:Zfp770	APN	2	114,026,719 (GRCm39)	missense	probably damaging	0.96
IGL03227:Zfp770	APN	2	114,027,570 (GRCm39)	nonsense	probably null
R0057:Zfp770	UTSW	2	114,027,713 (GRCm39)	nonsense	probably null
R0057:Zfp770	UTSW	2	114,027,713 (GRCm39)	nonsense	probably null
R1081:Zfp770	UTSW	2	114,027,608 (GRCm39)	missense	probably damaging	1.00
R1446:Zfp770	UTSW	2	114,027,514 (GRCm39)	missense	probably damaging	0.99
R4477:Zfp770	UTSW	2	114,027,365 (GRCm39)	missense	probably damaging	1.00
R4597:Zfp770	UTSW	2	114,027,251 (GRCm39)	missense	possibly damaging	0.46
R4964:Zfp770	UTSW	2	114,027,868 (GRCm39)	missense	probably benign	0.24
R4966:Zfp770	UTSW	2	114,027,868 (GRCm39)	missense	probably benign	0.24
R5259:Zfp770	UTSW	2	114,027,674 (GRCm39)	missense	probably benign	0.00
R5440:Zfp770	UTSW	2	114,026,596 (GRCm39)	missense	probably benign	0.42
R5910:Zfp770	UTSW	2	114,026,713 (GRCm39)	nonsense	probably null
R5941:Zfp770	UTSW	2	114,028,027 (GRCm39)	missense	possibly damaging	0.83
R6074:Zfp770	UTSW	2	114,026,870 (GRCm39)	missense	possibly damaging	0.68
R6341:Zfp770	UTSW	2	114,027,240 (GRCm39)	missense	probably benign	0.14
R7181:Zfp770	UTSW	2	114,027,872 (GRCm39)	missense	probably damaging	1.00
R7288:Zfp770	UTSW	2	114,026,142 (GRCm39)	nonsense	probably null
R7935:Zfp770	UTSW	2	114,027,305 (GRCm39)	missense	probably benign	0.00
R8119:Zfp770	UTSW	2	114,027,508 (GRCm39)	missense	probably damaging	1.00
R8304:Zfp770	UTSW	2	114,027,891 (GRCm39)	missense	probably damaging	1.00
R9356:Zfp770	UTSW	2	114,026,917 (GRCm39)	missense	possibly damaging	0.83
R9657:Zfp770	UTSW	2	114,027,766 (GRCm39)	missense	probably damaging	0.97
R9663:Zfp770	UTSW	2	114,026,949 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16