Incidental Mutation 'IGL02601:Stk4'
ID 300074
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk4
Ensembl Gene ENSMUSG00000018209
Gene Name serine/threonine kinase 4
Synonyms sterile 20-like kinase 1, Kas-2, Ysk3, Mst1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02601
Quality Score
Status
Chromosome 2
Chromosomal Location 163916033-163997444 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 163928462 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 97 (L97Q)
Ref Sequence ENSEMBL: ENSMUSP00000122440 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018353] [ENSMUST00000134078]
AlphaFold Q9JI11
Predicted Effect probably damaging
Transcript: ENSMUST00000018353
AA Change: L98Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000018353
Gene: ENSMUSG00000018209
AA Change: L98Q

DomainStartEndE-ValueType
S_TKc 30 281 1.97e-104 SMART
low complexity region 311 326 N/A INTRINSIC
Pfam:Mst1_SARAH 433 480 2.4e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000134078
AA Change: L97Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000122440
Gene: ENSMUSG00000018209
AA Change: L97Q

DomainStartEndE-ValueType
Pfam:Pkinase 29 113 7.2e-22 PFAM
Pfam:Pkinase_Tyr 29 113 1.1e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153319
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele have low numbers of na�ve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adap1 C T 5: 139,293,541 (GRCm39) V57M probably damaging Het
Agap3 A G 5: 24,688,369 (GRCm39) K23E possibly damaging Het
Anln A T 9: 22,249,331 (GRCm39) I132K probably damaging Het
Anxa4 T C 6: 86,737,683 (GRCm39) T13A probably benign Het
Bdp1 A T 13: 100,235,022 (GRCm39) Y191N possibly damaging Het
Carm1 G A 9: 21,498,204 (GRCm39) V403M probably damaging Het
Cbx7 A G 15: 79,807,671 (GRCm39) probably null Het
Chd8 A C 14: 52,451,757 (GRCm39) N16K possibly damaging Het
Crtc3 A T 7: 80,242,315 (GRCm39) D499E probably damaging Het
Cul3 A G 1: 80,249,432 (GRCm39) probably benign Het
D430041D05Rik T C 2: 104,060,631 (GRCm39) D1421G probably damaging Het
Fgb T A 3: 82,952,367 (GRCm39) E167D probably benign Het
Gimap6 T A 6: 48,679,409 (GRCm39) Q209L probably damaging Het
Gm3604 G A 13: 62,517,990 (GRCm39) H123Y possibly damaging Het
Gm5884 A T 6: 128,622,749 (GRCm39) noncoding transcript Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Obox3 T C 7: 15,360,848 (GRCm39) E97G probably damaging Het
Obsl1 T C 1: 75,466,264 (GRCm39) H1488R probably benign Het
Or4e1 A T 14: 52,700,802 (GRCm39) Y221* probably null Het
Or6c75 A G 10: 129,337,723 (GRCm39) *323W probably null Het
Pak5 T A 2: 135,958,855 (GRCm39) K78* probably null Het
Paqr9 A G 9: 95,442,877 (GRCm39) N289S probably damaging Het
Pde3b G A 7: 114,122,577 (GRCm39) R715H probably damaging Het
Pglyrp2 T C 17: 32,634,835 (GRCm39) H509R probably benign Het
Pik3ap1 A C 19: 41,290,881 (GRCm39) N550K probably benign Het
Pon3 A G 6: 5,221,671 (GRCm39) Y320H probably damaging Het
Ptprt T A 2: 161,608,227 (GRCm39) T690S probably benign Het
Ptprz1 T A 6: 23,000,686 (GRCm39) D925E probably benign Het
Rag1 T C 2: 101,473,018 (GRCm39) D708G probably damaging Het
Rbm12 C T 2: 155,937,480 (GRCm39) probably benign Het
Rbmy1b A G Y: 3,774,885 (GRCm39) I27M probably benign Het
Rfx2 G A 17: 57,092,354 (GRCm39) H315Y possibly damaging Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Sis T C 3: 72,820,543 (GRCm39) N1407S probably benign Het
Slco1c1 T A 6: 141,490,555 (GRCm39) L261Q probably damaging Het
Sox30 T G 11: 45,875,589 (GRCm39) L447R possibly damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Ssu72 A G 4: 155,789,882 (GRCm39) N15S possibly damaging Het
Stat4 C T 1: 52,137,574 (GRCm39) S455F probably damaging Het
Sulf1 A T 1: 12,856,869 (GRCm39) N40I probably damaging Het
Sympk G A 7: 18,782,794 (GRCm39) V877I probably benign Het
Taar7b A T 10: 23,876,204 (GRCm39) H123L probably damaging Het
Teddm1b A G 1: 153,750,362 (GRCm39) Y57C probably damaging Het
Tep1 A T 14: 51,070,935 (GRCm39) C2121* probably null Het
Tnfsf11 T A 14: 78,537,385 (GRCm39) R93* probably null Het
Tspan12 A C 6: 21,835,378 (GRCm39) probably benign Het
Tyrp1 A G 4: 80,759,012 (GRCm39) E295G probably null Het
Vps4a T C 8: 107,769,693 (GRCm39) I334T probably damaging Het
Zfhx3 T C 8: 109,583,462 (GRCm39) S1110P probably damaging Het
Zfp507 A G 7: 35,491,136 (GRCm39) S716P probably damaging Het
Other mutations in Stk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00672:Stk4 APN 2 163,959,999 (GRCm39) missense probably benign 0.05
IGL01583:Stk4 APN 2 163,916,134 (GRCm39) start codon destroyed probably null 0.21
IGL01933:Stk4 APN 2 163,940,505 (GRCm39) unclassified probably benign
IGL02084:Stk4 APN 2 163,928,527 (GRCm39) missense probably benign 0.05
IGL02423:Stk4 APN 2 163,928,419 (GRCm39) missense probably benign 0.00
IGL02712:Stk4 APN 2 163,938,817 (GRCm39) missense probably damaging 1.00
hallon UTSW 2 163,941,747 (GRCm39) critical splice donor site probably null
iwo_jima UTSW 2 163,930,879 (GRCm39) missense possibly damaging 0.94
ribeye UTSW 2 163,921,486 (GRCm39) missense probably damaging 1.00
Sergeant UTSW 2 163,941,632 (GRCm39) missense probably benign
stryker UTSW 2 163,925,608 (GRCm39) nonsense probably null
R0377:Stk4 UTSW 2 163,938,720 (GRCm39) missense probably damaging 1.00
R0607:Stk4 UTSW 2 163,940,462 (GRCm39) missense probably damaging 1.00
R1403:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1403:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1404:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1404:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1405:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1405:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1406:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1406:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1972:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1973:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1976:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R2025:Stk4 UTSW 2 163,938,751 (GRCm39) missense probably damaging 1.00
R3155:Stk4 UTSW 2 163,993,663 (GRCm39) missense probably benign 0.01
R3732:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3732:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3733:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3734:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R4288:Stk4 UTSW 2 163,941,632 (GRCm39) missense probably benign
R4296:Stk4 UTSW 2 163,959,904 (GRCm39) missense possibly damaging 0.69
R4360:Stk4 UTSW 2 163,930,879 (GRCm39) missense possibly damaging 0.94
R4829:Stk4 UTSW 2 163,941,747 (GRCm39) critical splice donor site probably null
R4954:Stk4 UTSW 2 163,993,602 (GRCm39) missense probably damaging 1.00
R4954:Stk4 UTSW 2 163,993,601 (GRCm39) missense possibly damaging 0.75
R5088:Stk4 UTSW 2 163,925,608 (GRCm39) nonsense probably null
R5188:Stk4 UTSW 2 163,930,828 (GRCm39) missense possibly damaging 0.85
R5283:Stk4 UTSW 2 163,952,199 (GRCm39) nonsense probably null
R5554:Stk4 UTSW 2 163,941,645 (GRCm39) missense probably benign
R5605:Stk4 UTSW 2 163,921,486 (GRCm39) missense probably damaging 1.00
R5694:Stk4 UTSW 2 163,942,484 (GRCm39) missense possibly damaging 0.87
R5711:Stk4 UTSW 2 163,941,674 (GRCm39) missense probably benign 0.20
R7453:Stk4 UTSW 2 163,928,522 (GRCm39) missense probably benign 0.01
R7698:Stk4 UTSW 2 163,925,663 (GRCm39) missense probably damaging 1.00
R7726:Stk4 UTSW 2 163,952,146 (GRCm39) start codon destroyed probably null
R8177:Stk4 UTSW 2 163,930,777 (GRCm39) missense probably damaging 0.99
R9076:Stk4 UTSW 2 163,959,985 (GRCm39) missense probably benign
R9378:Stk4 UTSW 2 163,952,136 (GRCm39) intron probably benign
Posted On 2015-04-16