Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02602:Vmn1r191'

300106

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r191

Ensembl Gene

ENSMUSG00000095916

Gene Name

vomeronasal 1 receptor 191

Synonyms

V1rh15

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.153) question?

Stock #

IGL02602

Quality Score

Status

Chromosome

Chromosomal Location

22362856-22363752 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22363635 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 40 (K40E)

Ref Sequence

ENSEMBL: ENSMUSP00000072206 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072369]

AlphaFold

Q8K4D0

Predicted Effect

probably damaging
Transcript: ENSMUST00000072369
AA Change: K40E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000072206
Gene: ENSMUSG00000095916
AA Change: K40E

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
Pfam:V1R	35	291	4.4e-33	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000120067

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsf2	A	G	11: 94,461,291 (GRCm39)		probably benign	Het
Arhgap20	A	T	9: 51,737,143 (GRCm39)	I148F	probably damaging	Het
Arhgef10	C	T	8: 14,980,198 (GRCm39)	A146V	probably benign	Het
Cdk13	A	G	13: 17,901,745 (GRCm39)	F997L	probably damaging	Het
Cep162	G	A	9: 87,128,206 (GRCm39)	H170Y	probably benign	Het
Clasp1	T	C	1: 118,399,515 (GRCm39)	F220L	probably damaging	Het
Clock	C	A	5: 76,402,273 (GRCm39)	G129V	probably null	Het
Clock	C	T	5: 76,402,274 (GRCm39)	G129R	probably damaging	Het
Cybrd1	T	C	2: 70,948,492 (GRCm39)	L10P	probably damaging	Het
Cyp7a1	A	G	4: 6,272,871 (GRCm39)	I114T	possibly damaging	Het
Epha7	T	A	4: 28,871,877 (GRCm39)	V402D	possibly damaging	Het
Fam228a	G	A	12: 4,782,808 (GRCm39)	T95I	probably benign	Het
Gm7589	C	T	9: 59,053,441 (GRCm39)		noncoding transcript	Het
Klf4	C	A	4: 55,530,595 (GRCm39)	R172L	probably damaging	Het
Macf1	A	G	4: 123,248,956 (GRCm39)	S7190P	probably damaging	Het
Mga	A	G	2: 119,762,365 (GRCm39)	T1119A	possibly damaging	Het
Nmur2	T	A	11: 55,917,889 (GRCm39)	T367S	probably benign	Het
Ogfr	A	G	2: 180,237,230 (GRCm39)	D605G	possibly damaging	Het
Or4f61	A	G	2: 111,922,906 (GRCm39)	F47L	probably benign	Het
Pcdhb1	A	T	18: 37,399,849 (GRCm39)	N600I	probably damaging	Het
Pkhd1l1	T	C	15: 44,421,327 (GRCm39)	S3032P	probably damaging	Het
Ppp2r5e	A	G	12: 75,540,213 (GRCm39)	L144P	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Ryr2	T	C	13: 11,569,397 (GRCm39)		probably benign	Het
Scarb2	A	G	5: 92,596,415 (GRCm39)	Y410H	probably benign	Het
Slc12a1	A	G	2: 124,996,162 (GRCm39)	Y105C	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Stt3b	A	T	9: 115,105,846 (GRCm39)	S210T	probably damaging	Het
Sulf2	T	C	2: 165,923,220 (GRCm39)	H635R	probably benign	Het
Tmem167	C	A	13: 90,252,499 (GRCm39)	R52S	probably damaging	Het
Tsga13	G	A	6: 30,879,212 (GRCm39)	T167I	possibly damaging	Het
Txk	T	C	5: 72,865,063 (GRCm39)	R271G	possibly damaging	Het
Vmn1r69	T	A	7: 10,313,901 (GRCm39)	N277Y	probably benign	Het

Other mutations in Vmn1r191

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Vmn1r191	APN	13	22,362,890 (GRCm39)	missense	probably damaging	1.00
IGL01645:Vmn1r191	APN	13	22,363,614 (GRCm39)	missense	probably benign	0.03
IGL02224:Vmn1r191	APN	13	22,363,068 (GRCm39)	missense	probably damaging	1.00
IGL02321:Vmn1r191	APN	13	22,363,068 (GRCm39)	nonsense	probably null
IGL02516:Vmn1r191	APN	13	22,363,710 (GRCm39)	missense	probably benign	0.38
IGL02630:Vmn1r191	APN	13	22,363,431 (GRCm39)	missense	possibly damaging	0.95
IGL03077:Vmn1r191	APN	13	22,363,316 (GRCm39)	missense	probably benign	0.07
IGL03380:Vmn1r191	APN	13	22,363,055 (GRCm39)	missense	probably damaging	0.99
R0571:Vmn1r191	UTSW	13	22,363,217 (GRCm39)	missense	probably damaging	0.96
R0981:Vmn1r191	UTSW	13	22,363,389 (GRCm39)	missense	probably benign	0.00
R1672:Vmn1r191	UTSW	13	22,363,262 (GRCm39)	missense	probably benign	0.01
R1955:Vmn1r191	UTSW	13	22,362,985 (GRCm39)	missense	possibly damaging	0.79
R1969:Vmn1r191	UTSW	13	22,362,952 (GRCm39)	missense	possibly damaging	0.71
R5059:Vmn1r191	UTSW	13	22,363,163 (GRCm39)	missense	probably damaging	1.00
R6484:Vmn1r191	UTSW	13	22,362,918 (GRCm39)	missense	probably benign	0.00
R6736:Vmn1r191	UTSW	13	22,363,720 (GRCm39)	missense	probably benign	0.14
R7063:Vmn1r191	UTSW	13	22,362,864 (GRCm39)	missense	probably benign	0.08
R7475:Vmn1r191	UTSW	13	22,362,942 (GRCm39)	missense	probably benign	0.00
R9699:Vmn1r191	UTSW	13	22,363,355 (GRCm39)	missense	probably benign	0.25

Posted On

2015-04-16