Incidental Mutation 'IGL02603:Psg19'
ID300142
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Psg19
Ensembl Gene ENSMUSG00000004542
Gene Namepregnancy specific glycoprotein 19
SynonymsCGM7, Cea-4, Cea4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.034) question?
Stock #IGL02603
Quality Score
Status
Chromosome7
Chromosomal Location18789567-18798520 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 18792768 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 146 (S146P)
Ref Sequence ENSEMBL: ENSMUSP00000138621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004657] [ENSMUST00000182853]
Predicted Effect probably benign
Transcript: ENSMUST00000004657
AA Change: S266P

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000004657
Gene: ENSMUSG00000004542
AA Change: S266P

DomainStartEndE-ValueType
IG 40 141 9.2e-3 SMART
IG 160 261 4.5e0 SMART
IG 280 381 4.67e-4 SMART
IGc2 397 461 1.58e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182681
Predicted Effect probably benign
Transcript: ENSMUST00000182853
AA Change: S146P

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000138621
Gene: ENSMUSG00000004542
AA Change: S146P

DomainStartEndE-ValueType
IG 40 141 9.2e-3 SMART
IG 160 261 4.67e-4 SMART
IGc2 277 341 1.58e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182916
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207882
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,488,952 S3457P possibly damaging Het
Aipl1 A G 11: 72,036,700 I63T possibly damaging Het
Atp7b C T 8: 21,994,776 V1307M possibly damaging Het
Cdc20b T C 13: 113,078,755 S286P possibly damaging Het
Eif2ak4 G A 2: 118,450,326 R946H probably damaging Het
Fam98c A G 7: 29,154,448 S232P probably damaging Het
Glt1d1 G T 5: 127,632,345 R21L probably damaging Het
Gm5286 A T 3: 94,198,437 T21S possibly damaging Het
Gm5422 A G 10: 31,249,440 noncoding transcript Het
Haao T A 17: 83,835,541 D125V probably benign Het
Hipk1 A G 3: 103,750,272 V832A probably damaging Het
Lrrtm4 C A 6: 80,022,984 Q460K possibly damaging Het
Lyar A G 5: 38,234,061 N368S probably damaging Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Lztr1 C A 16: 17,509,686 N84K possibly damaging Het
Ndufa8 C A 2: 36,044,458 C36F probably damaging Het
Olfr136 T A 17: 38,335,513 S119T probably damaging Het
Olfr739 T A 14: 50,425,200 V227E probably damaging Het
Rbm12 C T 2: 156,095,560 probably benign Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Other mutations in Psg19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Psg19 APN 7 18794046 nonsense probably null
IGL01864:Psg19 APN 7 18794152 missense probably benign 0.03
IGL01996:Psg19 APN 7 18790061 missense possibly damaging 0.45
R0139:Psg19 UTSW 7 18797017 missense possibly damaging 0.65
R0894:Psg19 UTSW 7 18794062 missense probably benign 0.14
R1394:Psg19 UTSW 7 18797058 missense probably damaging 0.99
R1911:Psg19 UTSW 7 18794268 missense probably damaging 0.96
R2116:Psg19 UTSW 7 18794255 missense probably damaging 0.99
R2165:Psg19 UTSW 7 18796986 missense possibly damaging 0.70
R4791:Psg19 UTSW 7 18794146 missense probably damaging 1.00
R5093:Psg19 UTSW 7 18796969 missense probably benign 0.00
R6290:Psg19 UTSW 7 18794089 missense probably benign 0.00
Posted On2015-04-16