Incidental Mutation 'IGL02603:Cdc20b'
ID 300151
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc20b
Ensembl Gene ENSMUSG00000078926
Gene Name cell division cycle 20B
Synonyms EG238896, EG622422
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # IGL02603
Quality Score
Status
Chromosome 13
Chromosomal Location 113171645-113227729 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 113215289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 286 (S286P)
Ref Sequence ENSEMBL: ENSMUSP00000137915 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109244] [ENSMUST00000181117] [ENSMUST00000181568]
AlphaFold D3Z3I0
Predicted Effect possibly damaging
Transcript: ENSMUST00000109244
AA Change: S286P

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000104867
Gene: ENSMUSG00000078926
AA Change: S286P

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 517 2.01e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000181117
AA Change: S286P

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000137915
Gene: ENSMUSG00000078926
AA Change: S286P

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 513 1.78e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000181568
AA Change: S286P

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000137849
Gene: ENSMUSG00000078926
AA Change: S286P

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 431 475 2.01e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232584
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,637,071 (GRCm39) S3457P possibly damaging Het
Aipl1 A G 11: 71,927,526 (GRCm39) I63T possibly damaging Het
Atp7b C T 8: 22,484,792 (GRCm39) V1307M possibly damaging Het
Eif2ak4 G A 2: 118,280,807 (GRCm39) R946H probably damaging Het
Fam98c A G 7: 28,853,873 (GRCm39) S232P probably damaging Het
Glt1d1 G T 5: 127,709,409 (GRCm39) R21L probably damaging Het
Gm5422 A G 10: 31,125,436 (GRCm39) noncoding transcript Het
Haao T A 17: 84,142,970 (GRCm39) D125V probably benign Het
Hipk1 A G 3: 103,657,588 (GRCm39) V832A probably damaging Het
Lrrtm4 C A 6: 79,999,967 (GRCm39) Q460K possibly damaging Het
Lyar A G 5: 38,391,405 (GRCm39) N368S probably damaging Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Lztr1 C A 16: 17,327,550 (GRCm39) N84K possibly damaging Het
Ndufa8 C A 2: 35,934,470 (GRCm39) C36F probably damaging Het
Or11g24 T A 14: 50,662,657 (GRCm39) V227E probably damaging Het
Or2n1d T A 17: 38,646,404 (GRCm39) S119T probably damaging Het
Psg19 A G 7: 18,526,693 (GRCm39) S146P probably benign Het
Rbm12 C T 2: 155,937,480 (GRCm39) probably benign Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Spopfm3 A T 3: 94,105,744 (GRCm39) T21S possibly damaging Het
Other mutations in Cdc20b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01625:Cdc20b APN 13 113,196,319 (GRCm39) missense possibly damaging 0.74
IGL02663:Cdc20b APN 13 113,192,665 (GRCm39) critical splice donor site probably null
IGL03024:Cdc20b APN 13 113,227,576 (GRCm39) missense possibly damaging 0.58
IGL03379:Cdc20b APN 13 113,217,736 (GRCm39) missense probably damaging 1.00
H8930:Cdc20b UTSW 13 113,220,500 (GRCm39) missense probably damaging 1.00
R0207:Cdc20b UTSW 13 113,215,146 (GRCm39) missense probably damaging 1.00
R0347:Cdc20b UTSW 13 113,196,361 (GRCm39) missense probably damaging 0.97
R0448:Cdc20b UTSW 13 113,215,191 (GRCm39) missense probably damaging 1.00
R0499:Cdc20b UTSW 13 113,192,484 (GRCm39) missense probably benign 0.00
R1573:Cdc20b UTSW 13 113,192,478 (GRCm39) missense probably benign 0.26
R1651:Cdc20b UTSW 13 113,215,258 (GRCm39) nonsense probably null
R1786:Cdc20b UTSW 13 113,217,668 (GRCm39) missense probably damaging 1.00
R1929:Cdc20b UTSW 13 113,208,451 (GRCm39) missense probably benign 0.07
R2118:Cdc20b UTSW 13 113,215,232 (GRCm39) missense probably benign 0.30
R3436:Cdc20b UTSW 13 113,215,233 (GRCm39) missense probably damaging 0.99
R3508:Cdc20b UTSW 13 113,217,576 (GRCm39) missense possibly damaging 0.80
R3837:Cdc20b UTSW 13 113,220,542 (GRCm39) missense probably damaging 1.00
R4050:Cdc20b UTSW 13 113,200,819 (GRCm39) missense probably benign
R4521:Cdc20b UTSW 13 113,217,725 (GRCm39) missense probably damaging 1.00
R4786:Cdc20b UTSW 13 113,215,268 (GRCm39) missense probably damaging 1.00
R6079:Cdc20b UTSW 13 113,220,576 (GRCm39) missense probably damaging 1.00
R6610:Cdc20b UTSW 13 113,200,796 (GRCm39) missense probably benign 0.02
R6814:Cdc20b UTSW 13 113,220,509 (GRCm39) missense probably damaging 1.00
R6872:Cdc20b UTSW 13 113,220,509 (GRCm39) missense probably damaging 1.00
R6887:Cdc20b UTSW 13 113,215,187 (GRCm39) missense possibly damaging 0.88
R7144:Cdc20b UTSW 13 113,219,905 (GRCm39) missense probably benign 0.36
R7579:Cdc20b UTSW 13 113,173,582 (GRCm39) splice site probably null
R7770:Cdc20b UTSW 13 113,215,193 (GRCm39) missense probably benign 0.01
R8669:Cdc20b UTSW 13 113,208,460 (GRCm39) missense possibly damaging 0.83
R8985:Cdc20b UTSW 13 113,196,330 (GRCm39) nonsense probably null
R9182:Cdc20b UTSW 13 113,208,503 (GRCm39) critical splice donor site probably null
R9309:Cdc20b UTSW 13 113,216,472 (GRCm39) missense probably damaging 1.00
R9378:Cdc20b UTSW 13 113,192,631 (GRCm39) missense probably benign 0.03
U15987:Cdc20b UTSW 13 113,220,576 (GRCm39) missense probably damaging 1.00
X0064:Cdc20b UTSW 13 113,196,276 (GRCm39) missense possibly damaging 0.59
Posted On 2015-04-16