Incidental Mutation 'IGL02604:Or2a25'
ID 300182
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2a25
Ensembl Gene ENSMUSG00000045708
Gene Name olfactory receptor family 2 subfamily A member 25
Synonyms GA_x6K02T2P3E9-4647978-4647046, MOR261-1, Olfr447
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # IGL02604
Quality Score
Status
Chromosome 6
Chromosomal Location 42888459-42889391 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 42888992 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 178 (C178*)
Ref Sequence ENSEMBL: ENSMUSP00000149325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055763] [ENSMUST00000216408]
AlphaFold Q8VGP6
Predicted Effect probably null
Transcript: ENSMUST00000055763
AA Change: C178*
SMART Domains Protein: ENSMUSP00000052312
Gene: ENSMUSG00000045708
AA Change: C178*

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-60 PFAM
Pfam:7tm_1 40 289 6.3e-27 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216408
AA Change: C178*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik T C 17: 35,878,845 (GRCm39) V61A probably benign Het
Arfgef1 G A 1: 10,251,275 (GRCm39) probably benign Het
Arhgef4 T A 1: 34,850,804 (GRCm39) L594* probably null Het
Cacna2d3 T C 14: 29,015,066 (GRCm39) T375A possibly damaging Het
Calb2 A C 8: 110,875,160 (GRCm39) Y155D probably damaging Het
Camkmt A G 17: 85,404,053 (GRCm39) T92A possibly damaging Het
Cfap91 A G 16: 38,141,921 (GRCm39) probably benign Het
Chsy3 A G 18: 59,542,187 (GRCm39) S442G probably benign Het
Cyp4f13 T C 17: 33,151,395 (GRCm39) I173V probably benign Het
Dapk1 A G 13: 60,896,134 (GRCm39) T741A probably benign Het
Dennd3 T C 15: 73,428,252 (GRCm39) I866T probably damaging Het
Dhrs2 A T 14: 55,474,778 (GRCm39) I138F possibly damaging Het
Dscaml1 C T 9: 45,655,626 (GRCm39) probably benign Het
Fsbp A G 4: 11,584,147 (GRCm39) E282G probably damaging Het
Hpgds A T 6: 65,100,594 (GRCm39) L128Q probably damaging Het
Hspa9 A G 18: 35,087,266 (GRCm39) V13A unknown Het
Itgb3 A G 11: 104,553,269 (GRCm39) E709G probably damaging Het
Jarid2 T C 13: 45,027,877 (GRCm39) S148P probably damaging Het
Kcna6 C T 6: 126,716,167 (GRCm39) G241R probably benign Het
Kdm5a T A 6: 120,408,941 (GRCm39) N1541K probably benign Het
Kel C A 6: 41,664,516 (GRCm39) E640D probably damaging Het
Lcp1 A T 14: 75,461,566 (GRCm39) I520F probably benign Het
Lgr4 A G 2: 109,841,658 (GRCm39) I524V probably damaging Het
Mup20 A C 4: 61,970,141 (GRCm39) Y139D probably damaging Het
Notch4 T C 17: 34,784,362 (GRCm39) probably null Het
Obox7 A G 7: 14,399,293 (GRCm39) E173G probably benign Het
Or10a49 T A 7: 108,467,857 (GRCm39) Y168F probably benign Het
Or5w22 A T 2: 87,362,949 (GRCm39) T191S probably damaging Het
Or8b40 C T 9: 38,027,148 (GRCm39) Q19* probably null Het
Or9i1 T A 19: 13,839,170 (GRCm39) N4K probably benign Het
Patl2 T G 2: 121,955,814 (GRCm39) T241P possibly damaging Het
Pip5k1c C A 10: 81,153,155 (GRCm39) probably null Het
Plekhg6 T C 6: 125,354,342 (GRCm39) probably benign Het
Pon1 C A 6: 5,168,375 (GRCm39) G344V probably damaging Het
Ppp1r21 G T 17: 88,880,171 (GRCm39) K529N probably benign Het
Prdm15 A G 16: 97,623,142 (GRCm39) S203P probably benign Het
Psmc2 T A 5: 22,000,098 (GRCm39) probably null Het
Ptn T C 6: 36,692,653 (GRCm39) M166V unknown Het
Ptpn13 A G 5: 103,649,769 (GRCm39) N391D probably benign Het
Rnf214 A G 9: 45,780,841 (GRCm39) S383P probably damaging Het
Rufy4 T A 1: 74,173,348 (GRCm39) L438H probably damaging Het
Scarf2 A G 16: 17,621,608 (GRCm39) T353A probably damaging Het
Serpinb9e A C 13: 33,441,742 (GRCm39) I225L probably benign Het
Slc25a40 T C 5: 8,503,219 (GRCm39) V312A probably benign Het
Tmc3 A G 7: 83,271,827 (GRCm39) Y993C possibly damaging Het
Trim56 A C 5: 137,141,930 (GRCm39) C529G probably damaging Het
Trim8 T C 19: 46,503,917 (GRCm39) S490P probably damaging Het
Trmt6 A T 2: 132,652,357 (GRCm39) Y147* probably null Het
Vmn2r109 T A 17: 20,760,963 (GRCm39) H798L probably damaging Het
Vps35 A G 8: 86,013,018 (GRCm39) L153P probably damaging Het
Wdr82 T C 9: 106,060,880 (GRCm39) I131T probably damaging Het
Zfp69 A T 4: 120,788,660 (GRCm39) D218E probably benign Het
Other mutations in Or2a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02302:Or2a25 APN 6 42,889,272 (GRCm39) missense probably damaging 1.00
IGL02894:Or2a25 APN 6 42,888,451 (GRCm39) splice site probably benign
R0122:Or2a25 UTSW 6 42,888,889 (GRCm39) missense probably benign 0.00
R0172:Or2a25 UTSW 6 42,888,913 (GRCm39) missense probably benign 0.00
R0371:Or2a25 UTSW 6 42,888,872 (GRCm39) missense probably benign 0.14
R1709:Or2a25 UTSW 6 42,889,078 (GRCm39) missense possibly damaging 0.94
R2431:Or2a25 UTSW 6 42,888,946 (GRCm39) missense probably damaging 0.99
R3809:Or2a25 UTSW 6 42,889,271 (GRCm39) missense probably damaging 1.00
R4032:Or2a25 UTSW 6 42,888,559 (GRCm39) missense probably benign 0.08
R4242:Or2a25 UTSW 6 42,888,480 (GRCm39) missense possibly damaging 0.77
R4369:Or2a25 UTSW 6 42,889,211 (GRCm39) nonsense probably null
R4401:Or2a25 UTSW 6 42,889,260 (GRCm39) nonsense probably null
R4565:Or2a25 UTSW 6 42,888,472 (GRCm39) missense probably benign
R5646:Or2a25 UTSW 6 42,888,457 (GRCm39) splice site probably null
R5968:Or2a25 UTSW 6 42,888,480 (GRCm39) missense probably benign
R6804:Or2a25 UTSW 6 42,888,852 (GRCm39) missense probably benign
R6925:Or2a25 UTSW 6 42,888,791 (GRCm39) nonsense probably null
R8170:Or2a25 UTSW 6 42,889,125 (GRCm39) missense possibly damaging 0.73
R8358:Or2a25 UTSW 6 42,888,976 (GRCm39) missense possibly damaging 0.51
R8765:Or2a25 UTSW 6 42,889,102 (GRCm39) missense probably benign 0.34
R9005:Or2a25 UTSW 6 42,889,170 (GRCm39) missense probably damaging 1.00
R9015:Or2a25 UTSW 6 42,888,825 (GRCm39) missense possibly damaging 0.55
R9308:Or2a25 UTSW 6 42,888,931 (GRCm39) missense probably damaging 1.00
R9520:Or2a25 UTSW 6 42,889,051 (GRCm39) missense probably damaging 0.98
R9743:Or2a25 UTSW 6 42,888,835 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16